...-dense and gene-poor chromosome territories (CTs) are located in the center and periphery, respectively. We analyzed chicken DT40 cells in which Arp6 had been knocked out conditionally, and showed that the radial distribution of CTs was impaired in these knockout cells. Arp6 is an essential component...

... of Liverpool, Liverpool L69 3BX, UK ‡ These authors contributed equally to this work § Authors for correspondence ( karine.dubrana@cea.fr ; laure.sabatier@cea.fr ) 9 8 2010 © 2010. 2010 Chromosome territory Nuclear organization Homologues Heterologues Nucleolar organizer...

... and DAPI counterstain gray, except for F, in which the wild-type CT17 is shown in blue and the CT der(17) in red. Scale bar: 5 μm. (G-L) Quantitative evaluation of radial probe distributions in the interphase nucleus or the respective chromosome territory, using 3D-RRD or eADS software ( n =number...

... even though there is no detectable expression of the transgene at this site. This shows that reorganisation of chromosome territories and chromatin decondensation can be uncoupled from transcription itself and suggests that they can therefore operate upstream of gene expression. * Author...

... outside its chromosome territory. There is also a smaller proportion of centromeres located close to the nuclear periphery in hES cells compared to differentiated cells. We conclude that hES cell nuclei have a distinct nuclear architecture, especially at loci involved in maintaining pluripotency...

...Masahiko Kuroda; Hideyuki Tanabe; Keiichi Yoshida; Kosuke Oikawa; Akira Saito; Tomoharu Kiyuna; Hiroshi Mizusawa; Kiyoshi Mukai Chromosomes are highly restricted to specific chromosome territories within the interphase nucleus. The arrangement of chromosome territories is non-random, exhibiting...

... found that preferential association of SNRPN interhomologues did not occur during the cell cycle in HL60 cells, although this gene exhibited asynchronous replication and monoallelic expression in this cells. SNRPN was found to localize at the periphery of the chromosome territories...

... imaging microscopy revealed that these arrays were localized almost exclusively outside of chromosome territories. During mitosis the filaments disassembled and dispersed throughout the cytoplasm, while in anaphase-telophase the vimentin was recruited back into the nucleus and reassembled into filaments...