...Charmaine Yan Yu Wong; Hok Ning Tsui; Yue Wang; Karen Wing Yee Yuen ABSTRACT Chromosome segregation errors caused by centromere malfunction can lead to chromosome instability and aneuploidy. In Caenorhabditis elegans , the Argonaute protein CSR-1 is essential for proper chromosome segregation...

... cycle arrest. To elucidate their contributions to chromosome segregation, in this work, we investigated their centromere- and kinetochore-related functions of Bmh1 and Bmh2. Analysis of appropriate deletion mutants shows that Bmh isoforms have cumulative and non-shared isoform-specific contributions...

... of chromosome segregation ( Fig. S2 ). In nocodazole-treated secondary spermatocytes, chromosomes failed to separate and subsequently budded as diploid spermatids ( Fig. S2 ). Despite the lack of spindles, we found that chromosome-associated BUB-1–GFP exhibited timely dissociation from non-aligned chromosomes...

... and crosstalk of microtubules and actin at the cell cortex, thereby regulating the mitotic spindle machinery and chromosome segregation. Yet, the precise mechanisms linking plasma membrane remodelling to cell polarity and cortical cytoskeleton dynamics to ensure accurate execution of mitosis in mammalian...

... harmful degradation. However, there is accumulating evidence revealing the requirement of selective autophagy and functional lysosomes for a faithful chromosome segregation. Degradation is the most-studied lysosomal activity, but recently described alternative functions that operate in mitosis highlight...

.... , Plessner , M. and Grosse , R. ( 2017 ). Actin visualization at a glance . J. Cell Sci. 130 , 525 - 530 . 10.1242/jcs.204487 Mogessie , B. ( 2020 ). Visualization and functional analysis of spindle actin and chromosome segregation in mammalian oocytes . Methods Mol. Biol...

... chromatid cohesion, microtubule attachments and metaphase I arrest. Drosophila Chromosome segregation Kinetochore Meiosis Microtubule Oocyte National Institutes of Health http://dx.doi.org/10.13039/100000002 GM101955 Chromosome segregation errors during meiosis I or II...

... disassembly of the SC occurs prior to segregation of homologous chromosomes during meiosis I. We examined the requirements of the mammalian Aurora kinases (AURKA, AURKB and AURKC) during SC disassembly and chromosome segregation using a combination of chemical inhibition and gene deletion approaches. We find...

... replication and chromosome segregation. The parasite undergoes atypical endomitosis and endoreduplication with an intact nuclear membrane and intranuclear mitotic spindle. To understand these diverse modes of Plasmodium cell division, we have studied the behaviour and composition of the outer kinetochore...

...Banafsheh Etemad; Abel Vertesy; Timo E. F. Kuijt; Carlos Sacristan; Alexander van Oudenaarden; Geert J. P. L. Kops ABSTRACT The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by monitoring kinetochore–microtubule interactions. SAC proteins are shed from kinetochores once...

... ubiquitin-conjugating enzymes Chromosome segregation Louisiana State University 10.13039/100008294 Protein ubiquitylation is a common and complex protein modification in which the highly conserved ubiquitin protein is covalently linked to the ε amino group of lysine residues. Most...

... in cell biology continues to come from just a few well-established models. In this Review, I use the highly diverse strategies of chromosome segregation in eukaryotes as an instrument for a more general discussion on phenotypic variation, possible rules underlying its emergence and its utility...

... attributed. Highlighted Article: Micronuclei, which are common in cancer cells, are prone to missegregation owing to kinetochore assembly defects. This represents a mechanism to delay the reincorporation of excess chromosome(s) and/or damaged DNA. Micronucleus Chromosome segregation...

...Zhen-Yu She; Wan-Xi Yang ABSTRACT During eukaryote cell division, molecular motors are crucial regulators of microtubule organization, spindle assembly, chromosome segregation and intracellular transport. The kinesin-14 motors are evolutionarily conserved minus-end-directed kinesin motors...

... and cancer. Roles of the Smc5/6 structural maintenance of chromosomes complex in pluripotent stem cell genome maintenance have not been investigated, despite its important roles in DNA synthesis, DNA repair and chromosome segregation as evaluated in other model systems. Using mouse embryonic stem cells...

...Ai Takemoto; Shigehiro A. Kawashima; Juan-Juan Li; Linda Jeffery; Kenzo Yamatsugu; Olivier Elemento; Paul Nurse ABSTRACT Here, we screened a 10,371 library of diverse molecules using a drug-sensitive fission yeast strain to identify compounds which cause defects in chromosome segregation during...

...Heather D. Eshleman; David O. Morgan ABSTRACT Sister chromatid bi-orientation on the mitotic spindle is essential for proper chromosome segregation. Defects in bi-orientation are sensed and corrected to prevent chromosome mis-segregation and aneuploidy. This response depends on the adaptor protein...

.... , Korinth   D. , Meraldi   P. ( 2009 ). Bub1 regulates chromosome segregation in a kinetochore-independent manner.   J. Cell Biol.   185 , 841 – 858 . 10.1083/jcb.200902128 Lampson   M. A. , Kapoor   T. M. ( 2005 ). The human mitotic checkpoint protein BubR1 regulates chromosome...

... by The Company of Biologists Ltd 2012 Nasonia vitripennis Chromosome segregation Early insect development Genome conflict Selfish DNA Since their discovery, B chromosomes have persisted as intriguing components of many eukaryotic genomes. Found in over two thousand plant and animal species so...

... factors such as the chromosome passenger complex. * Author for correspondence ( [email protected] ) 4 7 2011 © 2011. 2011 Meiosis Mitosis Microtubule Drosophila melanogaster Acentrosomal spindle Chromosome segregation Ran is a member of the Ras family of small...