... ). HP1-assisted Aurora B kinase activity prevents chromosome segregation errors . Dev. Cell 36 , 487 - 497 . 10.1016/j.devcel.2016.02.008 Baker , D. J. , Jin , F. , Jeganathan , K. B. and Van Deursen , J. M. ( 2009 ). Whole chromosome instability caused by Bub1...

... instability and tumorigenesis. Lats1 Hippo Lats2 YAP Chromosome instability Aberrant cell growth and chromosomal instability (CIN), two major hallmarks of human malignant cancer cells ( Hanahan and Weinberg, 2011 ; Gordon et al., 2012 ), are caused by malfunctions of the machineries...

... of the K-Ras -encoding gene), transient overexpression of Mad2 to induce aneuploidy causes tumour relapse, even after removal of K-Ras ( Sotillo et al., 2010 ). In flies that have extra centrosomes, there is neither a substantial increase in the level of chromosome instability, nor are merotelic...

... ‡ Author for correspondence ( [email protected] ) 4 7 2010 © 2010. 2010 Centromere Kinetochore Mitosis Chromosome instability Cal1 The centromeric regions of chromosomes direct formation of kinetochores, which allow chromosome attachment to spindle microtubules...

... cancer Chromosome instability Cell migration Cell adhesion β-catenin Asef IQGAP1 Actin EB1 Microtubules Germ-line mutations in the APC gene result in familial adenomatous polyposis (FAP), which is characterized by numerous polyps in the intestines ( Groden et al., 1991 ; Kinzler et al...

... is also associated with structural chromosomal instability. HEL and CMK megakaryocytic and U937 monocytic cell lines were cultured in RPMI 1640 medium (Gibco) supplemented with 10% (vol/vol) foetal calf serum (Bioclear), 2 mM L-glutamine (Gibco) and penicillin/streptomycin (Gibco). Cells were maintained...