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Keywords: Chromosome
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (3): jcs258745.
Published: 2 February 2022
...Aaron R. Tipton; Gary J. Gorbsky ABSTRACT The microtubules of the mitotic spindle mediate chromosome alignment to the metaphase plate, then sister chromatid segregation to the spindle poles in anaphase. Previous analyses of spindle microtubule kinetics utilizing fluorescence dissipation after...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs251025.
Published: 8 January 2021
...Zoë Geraghty; Christina Barnard; Pelin Uluocak; Ulrike Gruneberg ABSTRACT Errors in mitotic chromosome segregation can lead to DNA damage and aneuploidy, both hallmarks of cancer. To achieve synchronous error-free segregation, mitotic chromosomes must align at the metaphase plate with stable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs214577.
Published: 16 August 2018
...Julie K. Monda; Iain M. Cheeseman ABSTRACT Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (9): jcs213140.
Published: 1 May 2018
... chromosome proteomics to study the role of the Seh1 protein in mitosis. Surprisingly, Seh1 is not required for the association of the Nup107 complex with mitotic chromosomes, but it is essential for the association of both the GATOR2 complex and nucleoporin Nup153 with mitotic chromosomes. Our analysis also...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2016) 129 (21): 4014–4024.
Published: 1 November 2016
... microtubule-based structures, the spindle and phragmoplast, divide the chromosomes and the cell with extraordinary accuracy. Using a live-cell system and fluorescently labeled spindles and chromosomes, we found that the process self- corrects as meiosis proceeds. Metaphase spindles frequently initiate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 681–692.
Published: 15 February 2016
...Maya Spichal; Alice Brion; Sébastien Herbert; Axel Cournac; Martial Marbouty; Christophe Zimmer; Romain Koszul; Emmanuelle Fabre ABSTRACT Eukaryotic chromosomes undergo movements that are involved in the regulation of functional processes such as DNA repair. To better understand the origin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 566–575.
Published: 1 February 2015
...Elvira Nikalayevich; Hiroyuki Ohkura ABSTRACT Chromosome condensation during cell division is one of the most dramatic events in the cell cycle. Condensin and topoisomerase II are the most studied factors in chromosome condensation. However, their inactivation leads to only mild defects and little...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (6): 839–845.
Published: 15 March 2011
... regulatory elements, for instance enhancers and promoters, is crucial in gene control. Biochemical studies that were based on the chromosome conformation capture (3C) technology have confirmed that eukaryotic genomes are highly looped. Insight into the underlying principles comes from polymer models...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (24): 5057–5066.
Published: 15 December 2006
... interactions, causing defective spindle attachments and chromosome alignment during metaphase and mis-segregation during anaphase. In the absence of cohesin, sister kinetochore pairing and centromeric localization of chromosomal passenger proteins INCENP and aurora B were lost upon bipolar spindle attachment...
Journal Articles
J Cell Sci (2005) 118 (19): 4541–4550.
Published: 1 October 2005
... hybridization (FISH) with arm-specific DNA probes of chromosomes 1, 2 and 5, we visualized arm domains and established hierarchical levels of sperm chromatin structures. The compact chromosome territories, which in sperm have a preferred intranuclear localization, have an extended conformation represented...
Journal Articles
J Cell Sci (2005) 118 (11): 2529–2543.
Published: 1 June 2005
...Ellada Savvidou; Neville Cobbe; Søren Steffensen; Sue Cotterill; Margarete M. S. Heck The precise mechanism of chromosome condensation and decondensation remains a mystery, despite progress over the last 20 years aimed at identifying components essential to the mitotic compaction of the genome...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2002) 115 (18): 3547–3555.
Published: 15 September 2002
...Jun Zhou; Joyce Yao; Harish C. Joshi Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay...
Journal Articles
J Cell Sci (2001) 114 (24): 4575–4585.
Published: 15 December 2001
... of telophase chromosomes, and later distributes over the entire nuclear rim. Barrier-to-autointegration factor (BAF), a protein that binds nonspecifically to double-stranded DNA in vitro, co-localized with emerin at the ‘core’ region of chromosomes during telophase. An emerin mutant defective for binding...
Journal Articles
J Cell Sci (2000) 113 (14): 2585–2593.
Published: 15 July 2000
...Astrid E. Visser; Françoise Jaunin; Stanislav Fakan; Jacob A. Aten ABSTRACT Chromosome territories need to be well defined at high resolution before functional aspects of chromosome organization in interphase can be explored. To visualize chromosomes by electron microscopy (EM), the DNA of Chinese...