1-20 of 77
Keywords: Chromatin
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (7): jcs258391.
Published: 15 April 2021
... Chromatin Chromosome condensation Nuclear actin Histone Protamine Subcellular compartmentalization allows for complex modes of gene regulation in eukaryotic cells. The regulated and active transport of macromolecules between different compartments promotes cellular homeostasis and often drives...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs244749.
Published: 26 March 2021
...Paul B. Talbert; Steven Henikoff ABSTRACT Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1. Whereas...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs245282.
Published: 23 December 2020
...Georgia Rose Kafer; Yoshihisa Tanaka; Regina Rillo-Bohn; Eiko Shimizu; Kouichi Hasegawa; Peter M. Carlton ABSTRACT During the transition from pluripotency to a lineage-committed state, chromatin undergoes large-scale changes in structure, involving covalent modification of histone tails, use of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
... nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei relative to normal. Re-expression of wild-type K17, but not a mutant form lacking an intact nuclear localization signal (NLS), rescues nuclear morphology in KRT17...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243444.
Published: 21 July 2020
.... We analyzed histone H3 and H4 modifications during the cell cycle. Levels of active marks, such as acetylation and H3K4 methylation, were increased during the S phase, in association with chromatin duplication. By contrast, levels of some repressive modifications gradually increased during G2 and the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs243782.
Published: 18 May 2020
... both bacterial and eukaryotic genomes, although they vary in size. Importantly, genomes of metazoans also possess higher-order organization into A- and B-type compartments, regions of transcriptionally active and inactive chromatin, respectively. Until recently, nothing was known about the organization...
Journal Articles
J Cell Sci (2020) 133 (5): jcs241075.
Published: 10 March 2020
... NETosis), emphasize biophysical aspects and focus on three key principles – rearrangement and destabilization of the plasma membrane and the cytoskeleton, alterations and disassembly of the nuclear envelope, and chromatin decondensation as a driving force of intracellular reorganization. * Authors...
Journal Articles
J Cell Sci (2019) 132 (22): jcs235093.
Published: 21 November 2019
... regulate nuclear functions. Chromatin Nuclear organization Nucleolus Phase separation Compartmentalization is used throughout all kingdoms of biology to create functionally distinct units within a complex cellular environment. We usually think of these compartments as requiring a lipid...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 01 November 2019
... turn, involves components that retain RNA polymerase II in a paused state on gene promoters. Moreover, transcription during stress is regulated by a massive activation of enhancers and complex changes in chromatin organization. In this Review, we highlight the latest research regarding the molecular...
Journal Articles
J Cell Sci (2019) 132 (20): jcs233486.
Published: 18 October 2019
..., epigenetically represses anti-fibrotic gene expression via HDACs to promote fibroblast activation. Myofibroblasts Fibrosis Epigenetics Chromatin During normal physiological wound healing, fibroblasts become transiently activated into myofibroblasts to aid in tissue repair. Upon successful repair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs225524.
Published: 15 May 2019
... molecular GFP ladder, we show that in early mitosis, condensed chromatin excludes cytosolic proteins. When the NE reforms tightly around condensed chromatin in late mitosis, large GFP multimers are automatically excluded from the nucleus. This can be circumvented by limiting DNA condensation with Q15, a...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211094.
Published: 13 April 2018
... through the recruitment of chromatin-remodelling proteins and histone modification enzymes is NM1 ( Almuzzaini et al., 2015 ; Hofmann et al., 2006 ). Transmission electron microscopy (TEM) was performed to show more accurately that the PtdIns(4,5)P 2 foci are structures of 40–100 nm in size, and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2926–2940.
Published: 01 September 2017
...Luca Sardo; Angel Lin; Svetlana Khakhina; Lucas Beckman; Luis Ricon; Weam Elbezanti; Tara Jaison; Harshad Vishwasrao; Hari Shroff; Christopher Janetopoulos; Zachary A. Klase ABSTRACT Chromatin modification is traditionally assessed in biochemical assays that provide average measurements of static...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2551–2563.
Published: 01 August 2017
... cycle, replication-independent assembly is the only mode available for chromatin remodeling. For this reason, any nucleosome composition alterations accompanying transcriptional responses to physiological signals must occur through a DNA replication-independent pathway. HIRA is the histone chaperone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2066–2077.
Published: 15 June 2017
...Jindřiška Fišerová; Michaela Efenberková; Tomáš Sieger; Miloslava Maninová; Jana Uhlířová; Pavel Hozák ABSTRACT The nuclear periphery (NP) plays a substantial role in chromatin organization. Heterochromatin at the NP is interspersed with active chromatin surrounding nuclear pore complexes (NPCs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1501–1508.
Published: 01 May 2017
.... ( 2015 ). CTCF binding polarity determines chromatin looping . Mol. Cell   60 , 676 - 684 . 10.1016/j.molcel.2015.09.023 Dekker , J. and Mirny , L. ( 2016 ). The 3D genome as moderator of chromosomal communication . Cell   164 , 1110 - 1121 . 10.1016/j.cell.2016.02.007...
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (13): 2673–2683.
Published: 01 July 2016
...Denis Jullien; Julien Vignard; Yoann Fedor; Nicolas Béry; Aurélien Olichon; Michèle Crozatier; Monique Erard; Hervé Cassard; Bernard Ducommun; Bernard Salles; Gladys Mirey ABSTRACT Chromatin function is involved in many cellular processes, its visualization or modification being essential in many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2448–2461.
Published: 15 June 2016
.... Milburn; Jenny Dunn; Marco G. Casarotto; Stephen J. Turner; Nabila Seddiki; Anthony D. Kelleher; Sudha Rao ABSTRACT Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4380–4394.
Published: 01 December 2015
... modifications and chromatin accessibility to UV exposure remains poorly understood. Here, we report that UV exposure results in a genome-wide reduction in chromatin accessibility, while the distribution of the active regulatory mark H3K27ac undergoes massive reorganization. Genomic loci subjected to epigenetic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2956–2966.
Published: 01 July 2014
...Matthew R. King; Leah H. Matzat; Ryan K. Dale; Su Jun Lim; Elissa P. Lei ABSTRACT Chromatin insulators are DNA–protein complexes that are situated throughout the genome that are proposed to contribute to higher-order organization and demarcation into distinct transcriptional domains. Mounting...
Includes: Supplementary data