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Keywords: Chromatin
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Journal Articles
J Cell Sci (2022) 135 (4): jcs259196.
Published: 22 February 2022
...-influenced epigenetic marks, H2K119Ub and H3K4me2 ( Adams et al., 2018 ; Maezawa et al., 2018 ; Sin et al., 2012 ), have abnormal abundance and/or shifts from their normal autosomal or sex chromatin domains in Adad2 mutant cells. Additionally, lack of detectable PMSC in Adad2 mutants demonstrates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259132.
Published: 24 January 2022
... in embryonic gene expression and histone H3 acetylation in Drosophila . Chiffon Drosophila Chromatin Histone acetylation Development SAGA CHAT National Science Foundation http://dx.doi.org/10.13039/100000001 1930237 Purdue Research Foundation http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs258991.
Published: 24 January 2022
...Caitlin Connolly; Saori Takahashi; Hisashi Miura; Ichiro Hiratani; Nick Gilbert; Anne D. Donaldson; Shin-Ichiro Hiraga ABSTRACT The organisation of chromatin is closely intertwined with biological activities of chromosome domains, including transcription and DNA replication status. Scaffold...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs259307.
Published: 10 December 2021
...Ajay S. Labade; Adwait Salvi; Saswati Kar; Krishanpal Karmodiya; Kundan Sengupta ABSTRACT Nucleoporins regulate nuclear transport and are also involved in DNA damage, repair, cell cycle, chromatin organization and gene expression. Here, we studied the role of nucleoporin Nup93 and the chromatin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs259051.
Published: 5 August 2021
...David Z. Kochan; Julia S. P. Mawer; Jennifer Massen; Kiril Tishinov; Swati Parekh; Martin Graef; Anne Spang; Peter Tessarz ABSTRACT Gene expression involves regulation of chromatin structure and transcription, as well as processing of the transcribed mRNA. While there are feedback mechanisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs258374.
Published: 5 August 2021
...Michal Franek; Agata Kilar; Petr Fojtík; Marie Olšinová; Aleš Benda; Vladimír Rotrekl; Martina Dvořáčková; Jíří Fajkus ABSTRACT Analysis of histone variants and epigenetic marks is dominated by genome-wide approaches in the form of chromatin immunoprecipitation-sequencing (ChIP-seq) and related...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (7): jcs258391.
Published: 15 April 2021
... by The Company of Biologists Ltd 2021 Summary: Drosophila Importin-9 loss disrupts female and male meiosis. Importin-9 also functions during the histone to protamine transition and in nuclear transport of proteasome proteins during spermiogenesis. Nuclear import Karyopherin Meiosis Chromatin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs244749.
Published: 26 March 2021
...Paul B. Talbert; Steven Henikoff ABSTRACT Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1. Whereas...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs245282.
Published: 23 December 2020
...Georgia Rose Kafer; Yoshihisa Tanaka; Regina Rillo-Bohn; Eiko Shimizu; Kouichi Hasegawa; Peter M. Carlton ABSTRACT During the transition from pluripotency to a lineage-committed state, chromatin undergoes large-scale changes in structure, involving covalent modification of histone tails, use...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
... in nuclear morphology, chromatin organization, and cell proliferation. Human tumor keratinocyte cell lines lacking K17 exhibit flatter nuclei relative to normal. Re-expression of wild-type K17, but not a mutant form lacking an intact nuclear localization signal (NLS), rescues nuclear morphology in KRT17...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243444.
Published: 21 July 2020
.... We analyzed histone H3 and H4 modifications during the cell cycle. Levels of active marks, such as acetylation and H3K4 methylation, were increased during the S phase, in association with chromatin duplication. By contrast, levels of some repressive modifications gradually increased during G2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs243782.
Published: 18 May 2020
... in both bacterial and eukaryotic genomes, although they vary in size. Importantly, genomes of metazoans also possess higher-order organization into A- and B-type compartments, regions of transcriptionally active and inactive chromatin, respectively. Until recently, nothing was known about the organization...
Journal Articles
J Cell Sci (2020) 133 (5): jcs241075.
Published: 10 March 2020
... biophysical aspects and focus on three key principles – rearrangement and destabilization of the plasma membrane and the cytoskeleton, alterations and disassembly of the nuclear envelope, and chromatin decondensation as a driving force of intracellular reorganization. * Authors for correspondence...
Journal Articles
J Cell Sci (2019) 132 (22): jcs235093.
Published: 21 November 2019
... nuclear functions. Chromatin Nuclear organization Nucleolus Phase separation Compartmentalization is used throughout all kingdoms of biology to create functionally distinct units within a complex cellular environment. We usually think of these compartments as requiring a lipid bilayer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 1 November 2019
..., involves components that retain RNA polymerase II in a paused state on gene promoters. Moreover, transcription during stress is regulated by a massive activation of enhancers and complex changes in chromatin organization. In this Review, we highlight the latest research regarding the molecular mechanisms...
Journal Articles
J Cell Sci (2019) 132 (20): jcs233486.
Published: 18 October 2019
....23.23.8704-8717.2003 Kim , S. W. , Yoon , S.-J. , Chuong , E. , Oyolu , C. , Wills , A. E. , Gupta , R. and Baker , J. ( 2011 ). Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs . Dev. Biol.   357 , 492 - 504 . 10.1016...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs225524.
Published: 15 May 2019
... a molecular GFP ladder, we show that in early mitosis, condensed chromatin excludes cytosolic proteins. When the NE reforms tightly around condensed chromatin in late mitosis, large GFP multimers are automatically excluded from the nucleus. This can be circumvented by limiting DNA condensation with Q15...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211094.
Published: 13 April 2018
.... ( 2015 ). Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation . BMC Biol.   13 , 35 . 10.1186/s12915-015-0147-z Aronova , M. A. and Leapman , R. D. ( 2012 ). Development of electron energy-loss spectroscopy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2926–2940.
Published: 1 September 2017
...Luca Sardo; Angel Lin; Svetlana Khakhina; Lucas Beckman; Luis Ricon; Weam Elbezanti; Tara Jaison; Harshad Vishwasrao; Hari Shroff; Christopher Janetopoulos; Zachary A. Klase ABSTRACT Chromatin modification is traditionally assessed in biochemical assays that provide average measurements of static...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2551–2563.
Published: 1 August 2017
... cycle, replication-independent assembly is the only mode available for chromatin remodeling. For this reason, any nucleosome composition alterations accompanying transcriptional responses to physiological signals must occur through a DNA replication-independent pathway. HIRA is the histone chaperone...
Includes: Supplementary data