...Ignasi Casanellas; Hongkai Jiang; Carolyn M. David; Yolanda Vida; Ezequiel Pérez-Inestrosa; Josep Samitier; Anna Lagunas ABSTRACT Mesenchymal condensation is a prevalent morphogenetic transition that is essential in chondrogenesis. However, the current understanding of condensation mechanisms...

... mutants were used to investigate the role of BMPR1A and BMPR1B in chondrogenesis and osteogenesis. We found that BMPR1A is necessary for chondrogenesis and osteogenesis, and BMPR1B prevents hypertrophy. GDF5 BMP2 M1673 Chondrogenesis Hypertrophy Osteogenesis Bone morphogenetic proteins...

...Timothy P. Rutkowski; Anat Kohn; Deepika Sharma; Yinshi Ren; Anthony J. Mirando; Matthew J. Hilton ABSTRACT RBPjκ-dependent Notch signaling regulates multiple processes during cartilage development, including chondrogenesis, chondrocyte hypertrophy and cartilage matrix catabolism. Select members...

... by The Company of Biologists Ltd 2015 Summary: Wntless-mediated Wnt5b secretion modulates the proliferation of chondrogenic cells through fine-tuning regional Fgf3 expression during the development of craniofacial cartilages. Wnt5b Wntless Fgf3 Wnt secretion Chondrogenesis The secreted...

... in chondrogenesis cause chondrodysplasias and other skeletal defects. Using mesenchymal stem cells (MSCs) in an in vitro chondrogenesis assay, we found that knockdown of the diastrophic dysplasia (DTD) sulfate transporter (DTDST, also known as SLC26A2), which is required for normal cartilage development, blocked...

... formation of the hypertrophic zone in mutant humeri. In micromass cultures of Prrx1-Cre Shox2 mutant limb cells, we find that Shox2 deletion in undifferentiated mesenchymal cells results in increased BMP activity that enhances early chondrogenesis, but is insufficient to provoke chondrocyte maturation...

...@princeton.edu ) © 2012. Published by The Company of Biologists Ltd 2012 Fibronectin Chondrogenesis Stem cell differentiation Extracellular matrix, SOX9 The extracellular matrix (ECM) is a fibrillar network of proteins that has an essential role in determining tissue architecture by providing...

...Yoko Takigawa; Kenji Hata; Shuji Muramatsu; Katsuhiko Amano; Koichiro Ono; Makoto Wakabayashi; Akio Matsuda; Kenji Takada; Riko Nishimura; Toshiyuki Yoneda Sox9 is an essential transcription factor for chondrogenesis by regulating the expression of chondrogenic genes. However, its regulatory...

..., Wnt7a, Wnt9a and Wnt11. Moreover, Wif-1 was able to block Wnt3a-mediated activation of the canonical Wnt signalling pathway. Consequently, Wif-1 impaired growth of mesenchymal precursor cells and neutralised Wnt3a-mediated inhibition of chondrogenesis in micromass cultures of embryonic chick limb-bud...

... initial cellular condensation, whereas RECK knockdown suppressed the later ECM accumulation in the cartilaginous nodules. These results suggest that RECK expression at the right place (in the core of the nodules) and at the right time (only in the later phase) is important for proper chondrogenesis...

...Andrea D. Weston; Arthur V. Sampaio; Alan G. Ridgeway; T. Michael Underhill Signaling through the p38 mitogen-activated protein kinases (MAPKs) is essential for cartilage formation in primary cultures of limb mesenchyme. Here we show that, concurrent with a decrease in chondrogenesis, inhibition...

...', they undergo chondrogenesis and form a tissue that is morphologically and biochemically defined as cartilage. Here, we show that dual chondro-osteogenic differentiation can be obtained in the same micromass culture of human bone-marrow stromal cells. Human bone-marrow stromal cells were pellet cultured for 4...

... to induce chondrogenesis in cultures of human mesenchymal stem cells( Yoo et al., 1998 ; Mackay et al., 1998 ; Pittenger et al., 1999 ). For isolation of chondrogenic cells, EBs were cultivated as described above. Chondrogenic cells developed in dense, matrix-bordered areas called nodules. These nodules...

... Cancedda , F. and Cancedda , R. ( 1994 ). Ovotransferrin and ovotransferrin receptor expression during chondrogenesis and endochondral bone formation in developing chick embryo . J. Cell Biol . 124 , 579 – 588 . Gope , M. L. , Keinanen , R. A. , Kristo , P. A. , Conneely...

... when this paper was in the course of publication 15 04 1994 24 05 1994 © 1994 by Company of Biologists 1994 limb development chick embryo chondrogenesis extracellular matrix elastin fibrillin collagen morphogenesis Mechanical forces have often been proposed...

...Eleanor J. Mackie; Richard P. Tucker ABSTRACT The extracellular matrix glycoprotein, tenascin, is associated in vivo with mesenchyme undergoing osteogenesis and chondrogenesis, but is absent from mature bone and cartilage matrix. The expression of tenascin by osteoblastic cells in vitro has been...

... in bone marrow of a stromal stem cell. * Author for correspondence 02 08 1991 24 10 1991 © 1992 by Company of Biologists 1992 marrow stromal stem cell chondrogenesis collagen At the simplest level, bone marrow can be considered as a tissue composed of two cellular...