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Keywords: Chondrocytes
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Mitochondria
J Cell Sci (2020) 133 (22): jcs247353.
Published: 30 November 2020
... dysfunction-induced activation of the catabolic response in chondrocytes. Using cartilage slices from normal and OA cartilage, we showed that mitochondrial membrane potential was lower in OA cartilage, and that this was associated with increased production of mitochondrial superoxide and catabolic genes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2965–2972.
Published: 15 June 2012
... that LRP1 regulates WNT–β-catenin and protein kinase C signaling in chondrocytes, represses the hypertrophy of chondrocytes during endochondral ossification and that LRP1 is colocalized with a ligand, CCN family member 2 (CCN2; also known as connective tissue growth factor, CTGF), which conducts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (9): 1790–1800.
Published: 01 May 2006
..., we demonstrate that matrix metalloproteases (MMPs) produced and secreted by chondrocytes generate biologically functional 16K-prolactin from full-length prolactin. When incubated with human prolactin at neutral pH, chondrocyte extracts and conditioned medium, as well as chondrocytes in culture...
Journal Articles
J Cell Sci (2006) 119 (2): 380–387.
Published: 15 January 2006
...) signaling. In the present study, we show that activation of FGFR in chondrocytes induces the expression of SOCS1 and SOCS3 mRNA, and that these proteins are constitutively associated with FGFR3, as demonstrated by co-immunoprecipitation studies. Transfection of cells with FGFR3-GFP and SOCS1-CFP revealed...
Journal Articles
J Cell Sci (2003) 116 (22): 4587–4596.
Published: 15 November 2003
... and shared significantly reduced longitudinal bone growth. Mutant long bones were characterised by reduced numbers of growth plate chondrocytes and a severe osteoporosis. Decreased JunB levels in epiphysal growth plate chondrocytes and bone lining osteoblasts correlated with deregulated expression of Cyclin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (9): 1819–1826.
Published: 01 May 2003
...David Pfander; Thorsten Cramer; Ernestina Schipani; Randall S. Johnson The transcription factor HIF-1α plays a crucial role in modifying gene expression during low oxygen tension. In a previous study, we demonstrated that HIF-1α is essential for chondrocyte growth arrest and survival in vivo...
Journal Articles
J Cell Sci (2002) 115 (14): 3015–3025.
Published: 15 July 2002
...Ron A. Deckelbaum; George Chan; Dengshun Miao; David Goltzman; Andrew C. Karaplis Indian Hedgehog (Ihh), a member of the hedgehog (HH) family of secreted morphogens, and parathyroid hormone-related peptide (PTHrP) are key regulators of cartilage cell (chondrocyte) differentiation. We have...
Journal Articles
J Cell Sci (2002) 115 (3): 553–562.
Published: 01 February 2002
...Orit Rozenblatt-Rosen; Efrat Mosonego-Ornan; Einat Sadot; Liora Madar-Shapiro; Yuri Sheinin; Doron Ginsberg; Avner Yayon The effect of fibroblast growth factor (FGF) on mature chondrocytes, the cells responsible for axial skeletal development, is growth attenuation rather than stimulation...