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Keywords: Cholesterol
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Journal Articles
J Cell Sci (2022) 135 (5): jcs258672.
Published: 19 August 2021
...-expressing human cells impairs proteolytic Shh release from its lipidated terminal peptides, a process called ectodomain shedding. We also show that cholesterol export from Disp-deficient cells is reduced, that these cells contain increased cholesterol amounts in the plasma membrane, and that Shh shedding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs246785.
Published: 12 October 2020
... for caveolar morphogenesis, presumably through the shaping of the caveolar neck. Caveolar membranes contain abundant cholesterol. However, the role of cholesterol in PACSIN2-mediated membrane deformation remains unclear. Here, we show that the binding of PACSIN2 to the membrane can be negatively regulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs245357.
Published: 21 August 2020
... and results in mistargeting of LBR to the ER. LBR possesses a modular structure and corresponding bifunctionality, acting in heterochromatin organization via its N-terminus and in cholesterol biosynthesis via its sterol-reductase C-terminal domain. We show that TMEM147 physically interacts with LBR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs243840.
Published: 27 May 2020
... of osteoclast-like cells (OCLs). LDLR/LOX-1 dKO and LDLR sKO preosteoclasts exhibited decreased uptake of LDL. The cell surface cholesterol levels of both LDLR/LOX-1 dKO and LDLR sKO osteoclasts were lower than the levels of wild-type OCLs. Additionally, the amount of phosphatidylethanolamine (PE) on the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs241562.
Published: 11 May 2020
... roles of caveolins in a variety of cellular contexts including liver, brain, lymphocytes, cilia and cancer cells, as well as consider insights from invertebrate systems. Non-caveolar caveolins can determine the intracellular fluxes of active lipids, including cholesterol and sphingolipids. Accordingly...
Journal Articles
J Cell Sci (2019) 132 (23): jcs237271.
Published: 02 December 2019
... that atherosclerotic plaque macrophages contact agLDL and form an extracellular digestive compartment similar to that observed in vitro . During macrophage catabolism of agLDL in vitro , levels of free cholesterol in the agLDL are increased. HDL can extract free cholesterol directly from this agLDL and inhibit...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2018) 131 (13): jcs217075.
Published: 04 July 2018
... organizing system (MICOS) complexes, and to a lesser extent in OPA1. Moreover, muscles lacking ATAD3 showed altered cholesterol metabolism, accumulation of mitochondrial DNA (mtDNA) replication intermediates, progressive mtDNA depletion and deletions. Unexpectedly, decreases in the levels of some OXPHOS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211789.
Published: 19 April 2018
... degeneration. The signalling platform is dependent on cholesterol released from cholesterol esters by cholesterol ester hydrolases (CEHs). The activation of cPLA 2 requires cholesterol released from cholesterol esters by cholesterol ester hydrolases (CEHs), enzymes dependent upon platelet activating factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 3050–3059.
Published: 15 September 2017
...Ewan West; Craig Osborne; Clive Bate ABSTRACT Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrP C ) resulting in increased cholesterol...
Journal Articles
J Cell Sci (2017) 130 (16): 2682–2695.
Published: 15 August 2017
...Ji Hyun Kim; Ashutosh Singh; Maurizio Del Poeta; Deborah A. Brown; Erwin London ABSTRACT Ordered lipid domains (rafts) in plasma membranes have been hypothesized to participate in endocytosis based on inhibition of endocytosis by removal or sequestration of cholesterol. To more carefully...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2373–2387.
Published: 01 July 2015
... of endosomal Rab7 inhibited, and lowering membrane cholesterol levels favored STxB–saporin translocation. Interestingly, experiments with reducible and non-reducible linker-arm–STxB conjugates led to the conclusion that after translocation, STxB remains associated with the cytosolic membrane leaflet...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1422–1433.
Published: 01 April 2015
...Masashi Maekawa; Gregory D. Fairn ABSTRACT Cholesterol is an essential component of metazoan cellular membranes and it helps to maintain the structural integrity and fluidity of the plasma membrane. Here, we developed a cholesterol biosensor, termed D4H, based on the fourth domain of Clostridium...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1071–1081.
Published: 15 March 2015
... (SNAP) receptor (SNARE) proteins, which are key players in vesicle transport at the cell surface and intracellular compartments, but is also tightly modulated by cholesterol. Cholesterol-sensitive SNAREs at the cell surface are relatively well characterized, but it is less well understood how altered...
Journal Articles
J Cell Sci (2014) 127 (5): 929–938.
Published: 01 March 2014
... and the endosomal system. ER–endosome contacts intensify when endosomes mature, and the ER participates in endosomal processes, such as the termination of surface receptor signaling, multi-vesicular body formation, and transport and fusion events. Cholesterol and Ca 2+ are transferred between the ER and endosomes...
Journal Articles
J Cell Sci (2013) 126 (17): 3961–3971.
Published: 01 September 2013
... of myelinating cells. * Author for correspondence ( vilja.pietiainen@helsinki.fi ) 17 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 Endocytosis Cholesterol IDOL Multivesicular body NDRG1 Low-density lipoprotein (LDL)-cholesterol is internalized into cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3284–3294.
Published: 01 August 2013
... sites. CD44 is a key adhesion molecule for this interaction and its ligand-binding ability is tightly regulated. Here we show that the hyaluronan-binding ability of CD44 in T cells is upregulated by the depletion of membrane cholesterol with methyl-β-cyclodextrin (MβCD), which disintegrates lipid rafts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 2990–2996.
Published: 15 July 2013
...António J. M. Santos; Michael Meinecke; Michael B. Fessler; David W. Holden; Emmanuel Boucrot Summary Cell surface-exposed cholesterol is crucial for cell attachment and invasion of many viruses and bacteria, including the bacterium Salmonella , which causes typhoid fever and gastroenteritis. Using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2305–2313.
Published: 15 May 2013
...Stephen C. Tovey; Colin W. Taylor Summary Cholesterol depletion reversibly abolishes carbachol-evoked Ca 2+ release from inositol (1,4,5)-trisphosphate (IP 3 )-sensitive stores, without affecting the distribution of IP 3 receptors (IP 3 R) or endoplasmic reticulum, IP 3 formation or responses...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1345–1354.
Published: 15 March 2013
... degradation in an autophagy-independent manner by diverting the trafficking of both PrP and cholesterol to lysosomes. Our data indicate that tamoxifen, a well-characterized, widely available pharmaceutical, may have applications in the therapy of prion diseases. * These authors contributed equally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 4067–4076.
Published: 01 September 2012
... protein forms, we demonstrate that different Plins sequester to different types of lipid droplets that are composed of either triacylcerides or cholesterol esters. Furthermore, Plins with strong association preferences to triacylceride (or cholesterol ester) droplets can re-direct the relative...
Includes: Supplementary data