... cytoskeleton. We now describe a new function for the Chlamydia pneumoniae TarP member CPn0572, namely the ability to bind and alter the microtubule cytoskeleton. Thus, CPn0572 is unique in being the only prokaryotic protein that directly modulates both dynamic cytoskeletons of a eukaryotic cell. Ectopically...

...Lee Dolat; Raphael H. Valdivia ABSTRACT Our understanding of how the obligate intracellular bacterial pathogen Chlamydia trachomatis reprograms the function of infected cells in the upper genital tract is largely based on observations made in cell culture with transformed epithelial cell lines...

...Maud Dumoux; Anais Menny; Delphine Delacour; Richard D. Hayward ABSTRACT The obligate intracellular bacterial pathogen Chlamydia trachomatis deploys virulence effectors to subvert host cell functions enabling its replication within a specialized membrane-bound compartment termed an inclusion...

...María Eugenia Balañá; Florence Niedergang; Agathe Subtil; Andrés Alcover; Philippe Chavrier; Alice Dautry-Varsat The obligate intracellular bacterium Chlamydia penetrates the host epithelial cell by inducing cytoskeleton and membrane rearrangements reminiscent of phagocytosis. Here we report...

...Scott S. Grieshaber; Nicole A. Grieshaber; Ted Hackstadt Chlamydiae are pathogenic obligate intracellular bacteria with a biphasic developmental cycle that involves cell types adapted for extracellular survival (elementary bodies, EBs) and intracellular multiplication (reticulate bodies, RBs...

...Haralabia Boleti; Alexandre Benmerah; David M. Ojcius; Nadine Cerf-Bensussan; Alice Dautry-Varsat ABSTRACT Chlamydiae enter epithelial cells via a mechanism that still remains to be fully elucidated. In this study we investigated the pathway of entry of C. psittaci GPIC and C. trachomatis LGV/L2...