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Keywords: Chemical genetics
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Journal Articles
J Cell Sci (2008) 121 (6): 843–853.
Published: 15 March 2008
... of the most downstream SIN components and β-(1,3) glucan synthase to the contractile ring. Thus, we conclude that inactivation of Cdc2p is sufficient to activate the SIN and promote cytokinesis. Chemical genetics Cell cycle cdc2 Cytokinesis Yeast © The Company of Biologists Limited 2008 2008...
Journal Articles
J Cell Sci (2008) 121 (2): 143–148.
Published: 15 January 2008
... 272 , 216 -226. Burkard, M. E., Randall, C. L., Larochelle, S., Zhang, C., Shokat, K. M., Fisher, R. P. and Jallepalli, P. V. ( 2007 ). Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc. Natl. Acad. Sci...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3664–3675.
Published: 01 September 2006
..., inhibition of Aurora B kinase activity induces a penetrant anti-proliferative phenotype, indicating that Aurora B is an attractive anti-cancer drug target. Using molecular genetic and chemical-genetic approaches, we also probe the role of Aurora A kinase activity. We show that simultaneous repression...
Includes: Supplementary data