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Keywords: Ceramide
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Journal Articles
J Cell Sci (2023) 136 (10): jcs260923.
Published: 17 May 2023
... are involved in NE maintenance, but the underlying mechanism remains unclear. Here, we found that the ceramide synthase (CerS) homolog in the fission yeast Schizosaccharomyces pombe Tlc4 (SPAC17A2.02c) suppressed NE defects in cells lacking the NE proteins Lem2 and Bqt4. Tlc4 possesses a TRAM/LAG1/CLN8 domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259002.
Published: 7 March 2022
...Asmahan Abu-Arish; Elvis Pandžić; Yishan Luo; Yukiko Sato; Mark J. Turner; Paul W. Wiseman; John W. Hanrahan ABSTRACT Membrane proteins often cluster in nanoscale membrane domains (lipid rafts) that coalesce into ceramide-rich platforms during cell stress, however the clustering mechanisms remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs215152.
Published: 20 September 2018
..., such as VCP. (2) The regulated initiation stage may be bypassed by non-canonical, unrestrained activation of the downstream components, whereby Golgi-derived vesicles may contribute to autophagosome formation. (3) The presence of a second signal, for example, GCase-generated ceramide, may promote sustained...
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Imaging
J Cell Sci (2016) 129 (22): 4238–4251.
Published: 15 November 2016
... that acid sphingomyelinase (ASM; also known as SMPD1) regulates the conserved DAF-2 (the ortholog IGF-1R in mammals) RTK signaling pathway in Caenorhabditis elegans . How ASM and its catalytic products, ceramides, control RTK signaling pathways remain unclear. Here, we report that ASM regulates...
Includes: Supplementary data
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J Cell Sci (2006) 119 (13): 2688–2694.
Published: 1 July 2006
... and/or protein factors, thereby supporting the physiological Ca 2+ sensitivity of membrane fusion. Furthermore, the sphingomyelinase-driven generation of ceramide, contributing to the total membrane negative curvature, preserves the ability to fuse despite extensive cholesterol removal. Membrane microdomain...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (3): 475–486.
Published: 1 February 2003
... of cytosolic oligonucleosomes and by TUNEL assay to visualize DNA fragmentation. Nerve growth factor also induced a number of cell-death-related intracellular events including ceramide generation, caspase activation and poly-(ADP ribose)polymerase cleavage. Again, p75 receptor blockade completely abolished all...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (4): 677–684.
Published: 15 February 2001
... in the mitochondria. It also inhibited glucose deprivation-induced cytochrome c release from the mitochondria. It is possible that overexpression of Bcl2 prevents glucose deprivation-induced ceramide generation, probably by preventing the leakage of hydroperoxide from the mitochondria. We also observed that glucose...
Journal Articles
J Cell Sci (2000) 113 (18): 3299–3307.
Published: 15 September 2000
...Takuya Fukunaga; Masami Nagahama; Kiyotaka Hatsuzawa; Katsuko Tani; Akitsugu Yamamoto; Mitsuo Tagaya ABSTRACT We examined the effects of short chain and long chain ceramides on the stability of the Golgi apparatus. Short chain ceramides, C 2 - and C 6 -ceramides, blocked brefeldin A-induced Golgi...
Journal Articles
Journal Articles
J Cell Sci (1997) 110 (21): 2703–2714.
Published: 1 November 1997
... of GPI-anchored proteins before arrival to the Golgi. The end8-1/ lcb1-100 mutant is defective in ceramide synthesis. In vitro data suggest a requirement for ceramides after the exit from the ER. We therefore propose that ceramides might function in the fusion of a GPI-containing vesicle with the Golgi...