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Keywords: Centrosomes
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (24): jcs240267.
Published: 29 December 2020
...Ryoko Kuriyama; Cody R. Fisher ABSTRACT The centrosome, which consists of centrioles and pericentriolar material (PCM), becomes mature and assembles mitotic spindles by increasing the number of microtubules (MTs) emanating from the PCM. Among the molecules involved in centrosome maturation, Cep192...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs243543.
Published: 30 July 2020
...Divya Ganapathi Sankaran; Alexander J. Stemm-Wolf; Bailey L. McCurdy; Bharath Hariharan; Chad G. Pearson ABSTRACT Microtubules (MTs) promote important cellular functions including migration, intracellular trafficking, and chromosome segregation. The centrosome, comprised of two centrioles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (3): jcs210583.
Published: 08 February 2018
... a protease cleavage site between the head and stalk domains, making it susceptible to specific proteolytic cleavage. Drosophila Kinesin Molecular motor Protease Conditional mutant Centrosomes Fluctuation analysis Cytoskeletal motor proteins, including myosins, dyneins and kinesins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3789–3800.
Published: 15 November 2017
...Sascha Werner; Ana Pimenta-Marques; Mónica Bettencourt-Dias ABSTRACT Centrosomes and cilia are present in organisms from all branches of the eukaryotic tree of life. These structures are composed of microtubules and various other proteins, and are required for a plethora of cell processes...
Journal Articles
J Cell Sci (2017) 130 (22): 3779–3787.
Published: 15 November 2017
... that need instant attention. Examples are various types of DNA lesion but also the presence of extra centrosomes that can foster aneuploidy and, ultimately, promote DNA damage. Here, we review the role of PIDD1 in response to DNA damage and also highlight novel functions of PIDD1, such as in centrosome...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (3): 621–636.
Published: 01 February 2016
... was performed using the summed projections of acquired z -stacks in the areas indicated in the figures. γ-tubulin was used as a marker of the centrosome. The centrosome area was defined by a circle of 2-µm diameter and the centriolar satellite region by a circle of 5-µm diameter around γ-tubulin. The data were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5881–5886.
Published: 01 December 2012
... inner and outer centriole components. * Author for correspondence ( jordan.raff@path.ox.ac.uk ) 6 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Bld10 Cell biology Centrioles Centrosomes Cep135 Drosophila Centrioles are complex MT-based structures...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (18): 3125–3135.
Published: 15 September 2010
... to cancer progression. β-Catenin is also a centrosomal component involved in centrosome separation. Centrosomes nucleate interphase microtubules and the bipolar mitotic spindle in normal cells, but their organization and function in human cancers are abnormal. Here, we show that expression of stabilized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2743–2749.
Published: 15 August 2010
...Rebecca L. Ferguson; Gaetan Pascreau; James L. Maller Centrosomes are the major microtubule-organizing centers in animal cells and regulate formation of a bipolar mitotic spindle. Aberrant centrosome number causes chromosome mis-segregation, and has been implicated in genomic instability and tumor...
Journal Articles
J Cell Sci (2009) 122 (20): 3613–3618.
Published: 15 October 2009
... undergo further mitoses) and cyst cell daughters (which withdraw from the cell cycle and become quiescent). Although a considerable body of evidence indicates important roles for centrosomes in spindle orientation and asymmetrical division of GSCs, the behaviour and function of the centrioles in CPCs...
Journal Articles
J Cell Sci (2009) 122 (12): 2014–2023.
Published: 15 June 2009
...Ryoko Kuriyama; Monica Bettencourt-Dias; Ingrid Hoffmann; Marc Arnold; Lisa Sandvig Cancer cells frequently induce aberrant centrosomes, which have been implicated in cancer initiation and progression. Human colorectal cancer cells, HCT116, contain aberrant centrioles composed of disorganized...
Journal Articles
J Cell Sci (2009) 122 (11): 1747–1758.
Published: 01 June 2009
... null mutation. NudE can associate with kinetochores, spindles and the nuclear envelope. In nudE mutant brain mitotic cells, centrosomes are often detached from the poles. Moreover, the centrosomes of mutant primary spermatocytes do not migrate from the cell cortex to the nuclear envelope, establishing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2444–2453.
Published: 15 July 2007
...Ryoko Kuriyama; Yasuhiko Terada; Kyung S. Lee; Christopher L. C. Wang Centrosome duplication is tightly coupled with the cell cycle and neither too many nor too few centrosomes are induced in a normal cell. To study how centrosome assembly is regulated, we analyzed the abnormal process of multiple...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (23): 4707–4718.
Published: 01 December 2002
...Timothy L. Megraw; Sandhya Kilaru; F. Rudolf Turner; Thomas C. Kaufman The Drosophila Centrosomin (Cnn) protein is an essential core component of centrosomes in the early embryo. We have expressed a Cnn-GFP fusion construct in cleavage stage embryos, which rescues the maternal effect lethality...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (5): 941–948.
Published: 01 March 2002
... and in the centrosomal region, where it co-localizes withγ-tubulin. In Huntington's disease, inclusions are often nuclear or perinuclear. Since the perinuclear concentration of huntingtin does not depend on the number of its glutamine repeats, we propose that inclusions are found in perinuclear and intranuclear...