1-20 of 135
Keywords: Centrosome
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (16): jcs258462.
Published: 23 August 2021
... in ciliary protein trafficking, in the assembly of the T cell synapse. We demonstrated that BBS1 allows for centrosome polarization towards the immune synapse. This function is achieved through the clearance of centrosomal F-actin and its positive regulator WASH1 (also known as WASHC1), a process that we...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (16): jcs258544.
Published: 18 August 2021
... function. Centrosome Cilia Cytoskeleton Mechanobiology Organelle assembly Rootlets Medical Research Council http://dx.doi.org/10.13039/501100007155 University of Cambridge http://dx.doi.org/10.13039/501100000735 Isaac Newton Trust http://dx.doi.org/10.13039...
Journal Articles
J Cell Sci (2021) 134 (14): jcs253088.
Published: 26 July 2021
...Jeffrey C. Medley; Joseph R. DiPanni; Luke Schira; Blake M. Shaffou; Brandon M. Sebou; Mi Hye Song ABSTRACT Aberrant centrosome numbers are associated with human cancers. The levels of centrosome regulators positively correlate with centrosome number. Thus, tight control of centrosome protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs258987.
Published: 22 July 2021
... multiple functions at centrioles and centrosomes, and we have previously shown that in Drosophila phosphorylated Sas-4 initiates Polo recruitment to newly formed centrioles, while phosphorylated Spd-2 recruits Polo to the pericentriolar material (PCM) that assembles around mother centrioles in mitosis...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (14): jcs258397.
Published: 20 July 2021
...Nina Schweizer; Jens Lüders ABSTRACT Centrioles are microtubule-based cylindrical structures that assemble the centrosome and template the formation of cilia. The proximal part of centrioles is associated with the pericentriolar material, a protein scaffold from which microtubules are nucleated...
Journal Articles
J Cell Sci (2020) 133 (19): jcs241281.
Published: 01 October 2020
... defects. However, the regulation of cytoplasmic PLK1 is not fully understood. In this study, we show that CEP76, a centriolar protein, physically interacts with PLK1 and tightly controls the activation of cytoplasmic PLK1 during mitosis in human cells. We found that removal of centrosomes induced ectopic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs238931.
Published: 01 September 2020
...Yuki Yoshino; Akihiro Kobayashi; Huicheng Qi; Shino Endo; Zhenzhou Fang; Kazuha Shindo; Ryo Kanazawa; Natsuko Chiba ABSTRACT Breast cancer gene 1 (BRCA1) contributes to the regulation of centrosome number. We previously identified receptor for activated C kinase 1 (RACK1) as a BRCA1-interacting...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (12): jcs243592.
Published: 24 June 2020
... brain. Centriole Centrosome Cilia Primary microcephaly Neurodevelopmental disorder The centrosome, which is composed of a pair of centrioles surrounded by a matrix of pericentriolar material (PCM), serves as the microtubule organization center (MTOC) in cells. The paired centrioles...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (12): jcs244574.
Published: 22 June 2020
... assembly proteins [Plk4, Ana2 (the homologue of mammalian STIL), Sas-6, Sas-4 (mammalian CPAP) or Asl (mammalian Cep152)] leads to the absence of centrioles. Here, we use Sas-6 and Ana2 particles (SAPs) as a new model to probe the pathway of centriole and centrosome assembly. SAPs form in Drosophila eggs...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (11): jcs243113.
Published: 08 June 2020
...Sanjeev Chavan Nayak; Vegesna Radha ABSTRACT C3G (also known as RAPGEF1) plays a role in cell differentiation and is essential for early embryonic development in mice. In this study, we identify C3G as a centrosomal protein that colocalizes with cenexin (also known as ODF2) at the mother centriole...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (11): jcs244368.
Published: 03 June 2020
...-tubulin ring complexes are templates for microtubule nucleation and are composed of γ-tubulin and γ-tubulin complex proteins (GCPs). GCPs 4, 5 and 6 form a stable sub-complex that mediates assembly of the full complex. Microtubule nucleation γ-Tubulin ring complex Centrosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238352.
Published: 23 April 2020
.../BST20160116 Arquint , C. , Gabryjonczyk , A.-M. and Nigg , E. A. ( 2014 ). Centrosomes as signalling centres . Philos. Trans. R. Soc. Lond. B Biol. Sci.   369 , 20130464 . 10.1098/rstb.2013.0464 Azimzadeh , J. and Marshall , W. F. ( 2010 ). Building the centriole...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (4): jcs239616.
Published: 21 February 2020
...Delowar Hossain; Sunny Y.-P. Shih; Xintong Xiao; Julia White; William Y. Tsang ABSTRACT The centrosome linker serves to hold the duplicated centrosomes together until they separate in late G2/early mitosis. Precisely how the linker is assembled remains an open question. In this study, we identify...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (1): jcs239566.
Published: 02 January 2020
...Suzanna L. Prosser; Laurence Pelletier ABSTRACT Centriolar satellites are non-membranous cytoplasmic granules that concentrate in the vicinity of the centrosome, the major microtubule-organizing centre (MTOC) in animal cells. Originally assigned as conduits for the transport of proteins towards...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (19): jcs228486.
Published: 03 October 2019
... extent as deletion of centrin 2. Phenotypic analysis of the 4DA mutant revealed defects in centrosome localization, centriole satellite assembly, ciliary assembly and function and in interactions with POC5 and SFI1. These observations indicate that centrin 2 requires calcium-binding capacity for its...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2019) 132 (11): jcs227850.
Published: 07 June 2019
... and interactions with partners, such as microtubule severing enzymes, microtubule depolymerases and protein scaffolds. Together with minus-end-directed motors, these microtubule minus-end targeting proteins (−TIPs) also control the formation of microtubule-organizing centers, such as centrosomes and spindle poles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs225789.
Published: 26 March 2019
...Jaeyoun Kim; Jeongjin Kim; Kunsoo Rhee ABSTRACT A centrosome consists of a pair of centrioles and pericentriolar material (PCM). We manipulated expression of PCNT, a key PCM protein, and investigated roles of PCM in centriole behavior during mitosis. Deletion of PCNT had little effect on interphase...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (4): jcs228833.
Published: 20 February 2019
... of the important functions for the centriole organelle in cells. Centriole Centrosome Microtubules PLK4 STIL SAS-6 Over a century ago, Theodor Boveri spotted centrioles as beacons residing within centrosomes at spindle poles ( Boveri, 1900 ). It later became apparent that centrioles play...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs219501.
Published: 09 November 2018
...Susana Montenegro Gouveia; Sihem Zitouni; Dong Kong; Paulo Duarte; Beatriz Ferreira Gomes; Ana Laura Sousa; Erin M. Tranfield; Anthony Hyman; Jadranka Loncarek; Monica Bettencourt-Dias ABSTRACT The centrosome is an important microtubule-organising centre (MTOC) in animal cells. It consists of two...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs220954.
Published: 24 October 2018
...Kefei Yang; Marco Andreas Tylkowski; Daniela Hüber; Constanza Tapia Contreras; Sigrid Hoyer-Fender ABSTRACT The centrosome, as the main microtubule-organizing center, safeguards chromosome segregation by supporting the bipolar spindle. Centrosome aberrations are causally related to chromosome...
Includes: Supplementary data