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Keywords: Centromere
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Journal Articles
J Cell Sci (2021) 134 (15): jcs249763.
Published: 03 August 2021
...Conor P. Herlihy; Sabine Hahn; Nicole M. Hermance; Elizabeth A. Crowley; Amity L. Manning ABSTRACT Centromere structure and function are defined by the epigenetic modification of histones at centromeric and pericentromeric chromatin. The constitutive heterochromatin found at pericentromeric regions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs253724.
Published: 30 November 2020
... thermophila , the meiotic prophase nucleus stretches enormously, and chromosomes assume a bouquet-like arrangement in which telomeres and centromeres are attached to opposite poles of the nucleus. We have identified and characterized three meiosis-specific genes [meiotic nuclear elongation 1-3 ( MELG1-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs243303.
Published: 11 August 2020
...Koichiro Otake; Jun-ichirou Ohzeki; Nobuaki Shono; Kazuto Kugou; Koei Okazaki; Takahiro Nagase; Hisashi Yamakawa; Natalay Kouprina; Vladimir Larionov; Hiroshi Kimura; William C. Earnshaw; Hiroshi Masumoto ABSTRACT CENP-B binds to CENP-B boxes on centromeric satellite DNAs (known as alphoid DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs242610.
Published: 24 July 2020
...Nuno M. C. Martins; Fernanda Cisneros-Soberanis; Elisa Pesenti; Natalia Y. Kochanova; Wei-Hao Shang; Tetsuya Hori; Takahiro Nagase; Hiroshi Kimura; Vladimir Larionov; Hiroshi Masumoto; Tatsuo Fukagawa; William C. Earnshaw ABSTRACT Most eukaryotic centromeres are located within heterochromatic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 963–974.
Published: 01 March 2017
...Jorge Ferreira; Jeffrey H. Stear; Harald Saumweber ABSTRACT Centromeres form a chromosomal platform for the assembly of the kinetochores, which are required for orderly chromosome segregation. Assembly of both centromeres and kinetochores proceeds by a step-by-step mechanism that is regulated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4572–4587.
Published: 15 December 2015
... centromere identity, the pathways leading to the formation and maintenance of centromere chromatin remain unclear. We previously generated human artificial chromosomes (HACs) whose centromeres contain a synthetic alpha-satellite (alphoid) DNA array containing the tetracycline operator (alphoid tetO ). We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1732–1745.
Published: 01 May 2015
...Julien Mouysset; Samuel Gilberto; Michelle G. Meier; Fabienne Lampert; Mukta Belwal; Patrick Meraldi; Matthias Peter The mitotic spindle drives chromosome movement during mitosis and attaches to chromosomes at dedicated genomic loci named centromeres. Centromeres are epigenetically specified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3347–3359.
Published: 01 August 2014
...Ekaterina Boyarchuk; Dan Filipescu; Isabelle Vassias; Sylvain Cantaloube; Geneviève Almouzni ABSTRACT Correct chromosome segregation requires a unique chromatin environment at centromeres and in their vicinity. Here, we address how the deposition of canonical H2A and H2A.Z histone variants...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (20): 4782–4793.
Published: 15 October 2013
...Peter V. Lidsky; Frank Sprenger; Christian F. Lehner Summary Centromeres are specified epigenetically in animal cells. Therefore, faithful chromosome inheritance requires accurate maintenance of epigenetic centromere marks during progression through the cell cycle. Clarification of the mechanisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4239–4252.
Published: 15 September 2013
... at the central region of the synaptonemal complex from zygotene until diplotene. During late diplotene both proteins load to the chromocenters, where they colocalize with DNA Topoisomerase IIα, and then accumulate at the inner domain of the centromeres during the first and second meiotic divisions. Interestingly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1595–1603.
Published: 01 April 2013
..., which is the main cause of infertility, abortion and many genetic diseases. It is now well known that shugoshin and protein phosphatase 2A (PP2A) play important roles in the protection of centromeric cohesion during the first meiosis. PP2A can antagonize the phosphorylation of rec8, a member...
Journal Articles
J Cell Sci (2012) 125 (23): 5873–5880.
Published: 01 December 2012
..., chromosomes are arranged with telomeres assembled at one pole and centromeres at the opposite pole. This organisation is an exaggerated form of the bouquet, a meiotic chromosome arrangement that is widely conserved among eukaryotes. We show that centromere function is crucial for the formation of Tetrahymena...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 411–421.
Published: 15 January 2012
... of repressive chromatin. Here, we have engineered two types of acetylated chromatin within the centromere of a synthetic human artificial chromosome. Tethering a minimal NF-κB p65 activation domain within kinetochore-associated chromatin produced chromatin with high levels of histone H3 acetylated on lysine 9...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (22): 3871–3883.
Published: 15 November 2011
... complexes that assemble on the centromere of each sister chromatid. A key step in this process involves binding of the constitutive centromere-associated network (CCAN) to CENP-A, the histone H3 variant that constitutes centromeric nucleosomes. This network is proposed to operate as a persistent structural...
Journal Articles
J Cell Sci (2010) 123 (21): 3768–3779.
Published: 01 November 2010
...Ralf B. Schittenhelm; Friederike Althoff; Stefan Heidmann; Christian F. Lehner Propagation of centromere identity during cell cycle progression in higher eukaryotes depends critically on the faithful incorporation of a centromere-specific histone H3 variant encoded by CENPA in humans and cid...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (23): 4188–4196.
Published: 01 December 2007
... phosphorylation of the cohesin subunit SA2 and a cohesin-binding protein, called Wapl, removes the bulk of cohesin from the chromosome arms in early mitosis and allows the resolution of the chromosome arms. At anaphase onset, the protease separase removes centromere-enriched cohesin by proteolytic cleavage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (22): 3952–3964.
Published: 15 November 2007
... segregation is the most seriously affected by loss of topo II activity in living cells. There is considerable evidence that topo II plays a role at the centromere including: the centromere-specific accumulation of topo II protein; cytogenetic/molecular mapping of the catalytic activity of topo II to active...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4889–4900.
Published: 01 December 2006
... to monitor the spatial relationships of conserved cytological markers to the mitotic spindles, the centromeres and the spindle poles. Using both light- and transmission electron microscopy, we determined that Giardia has a semi-open mitosis with two extranuclear spindles that access chromatin through polar...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (2): 217–225.
Published: 15 January 2006
.... Immunocytological and electron microscopic analyses indicate that PAIR2 proteins associate with axial elements (AEs) at leptotene and zygotene, and is removed from the AEs of arm regions when homologous chromosomes have been synapsed. Immunocytology against a centromeric histone H3 variant revealed that PAIR2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (24): 5885–5898.
Published: 15 December 2005
...Hiroshi Nakashima; Megumi Nakano; Ryoko Ohnishi; Yasushi Hiraoka; Yasufumi Kaneda; Akio Sugino; Hiroshi Masumoto Alpha-satellite (alphoid) DNA is necessary for de novo formation of human artificial chromosomes (HACs) in human cultured cells. To investigate the relationship among centromeric...
Includes: Supplementary data