...Hélio Roque; Alan Wainman; Jennifer Richens; Kasia Kozyrska; Anna Franz; Jordan W. Raff Summary Cep135/Bld10 is a conserved centriolar protein required for the formation of the central cartwheel, an early intermediate in centriole assembly. Surprisingly, Cep135/Bld10 is not essential for centriole...

... undergo further mitoses) and cyst cell daughters (which withdraw from the cell cycle and become quiescent). Although a considerable body of evidence indicates important roles for centrosomes in spindle orientation and asymmetrical division of GSCs, the behaviour and function of the centrioles in CPCs...

...Ryoko Kuriyama; Monica Bettencourt-Dias; Ingrid Hoffmann; Marc Arnold; Lisa Sandvig Cancer cells frequently induce aberrant centrosomes, which have been implicated in cancer initiation and progression. Human colorectal cancer cells, HCT116, contain aberrant centrioles composed of disorganized...

... Endoplasmic reticulum Golgi Centrioles Micronemes Rhoptries The centriole is located near the Golgi and apicoplast in interphase cells ( Fig. 2C ), but migrates around the nucleus at the onset of mitosis ( Fig. 2F ), and replicates ( Fig. 2I ) before returning to the apical juxtanuclear region...

... centrosome replications in Chinese hamster ovary (CHO) cells induced by hydroxyurea (HU), which is known to uncouple the centrosome cycle from the cell cycle. Green fluorescent protein (GFP)-tagged centrin2 expressed in CHO cells labels both centrioles and the pericentriolar material (PCM). Counting...

... of centrioles it contains. In other experiments we show that centrosome reproduction is cytoplasmically controlled; centrosomes repeatedly double in a normal fashion in physically enucleated sea urchin eggs and eggs in which DNA synthesis has been inhibited by aphidicolin. In addition, we show that centrosomes...