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Keywords: Centriole
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Journal Articles
J Cell Sci (2021) 134 (14): jcs258987.
Published: 22 July 2021
... multiple functions at centrioles and centrosomes, and we have previously shown that in Drosophila phosphorylated Sas-4 initiates Polo recruitment to newly formed centrioles, while phosphorylated Spd-2 recruits Polo to the pericentriolar material (PCM) that assembles around mother centrioles in mitosis...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (14): jcs258397.
Published: 20 July 2021
...Nina Schweizer; Jens Lüders ABSTRACT Centrioles are microtubule-based cylindrical structures that assemble the centrosome and template the formation of cilia. The proximal part of centrioles is associated with the pericentriolar material, a protein scaffold from which microtubules are nucleated...
Journal Articles
J Cell Sci (2021) 134 (7): jcs252502.
Published: 13 April 2021
...Andrew P. Porter; Hannah Reed; Gavin R. M. White; Erinn-Lee Ogg; Helen J. Whalley; Angeliki Malliri ABSTRACT Centriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. Key to this is the regulated degradation of PLK4, the master regulator of centriole...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (19): jcs241281.
Published: 01 October 2020
... or financial interests. 4 11 2019 24 8 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: The centriole protein CEP76 is essential for the proper regulation of PLK1 in the cytoplasm to prevent its aberrant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs241836.
Published: 03 July 2020
...Huijie Zhao; Sen Yang; Qingxia Chen; Xiaomeng Duan; Guoqing Li; Qiongping Huang; Xueliang Zhu; Xiumin Yan ABSTRACT The Cep63–Cep152 complex located at the mother centriole recruits Plk4 to initiate centriole biogenesis. How the complex is targeted to mother centrioles, however, is unclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs243592.
Published: 24 June 2020
...Yi-Nan Lin; Ying-Shan Lee; Shu-Kuei Li; Tang K. Tang ABSTRACT Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by small brain size with mental retardation. CPAP (also known as CENPJ ), a known microcephaly-associated gene, plays a key role in centriole biogenesis. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs244574.
Published: 22 June 2020
...Lisa Gartenmann; Catarina C. Vicente; Alan Wainman; Zsofi A. Novak; Boris Sieber; Jennifer H. Richens; Jordan W. Raff ABSTRACT Centriole assembly requires a small number of conserved proteins. The precise pathway of centriole assembly has been difficult to study, as the lack of any one of the core...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240838.
Published: 04 June 2020
... associate with BBs and function in BB assembly, maturation and stability. Human POC5 (hPOC5) is a highly conserved centrin-binding protein that binds centrins through Sfi1p-like repeats and is required for building full-length, mature centrioles. Here, we use the BB-rich cytoskeleton of Tetrahymena...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238352.
Published: 23 April 2020
... is necessary for robust PLK4 activation and centriole duplication. Here, we show that CEP85 and STIL are also required for directional cancer cell migration. Mutational and functional analyses reveal that the interactions between CEP85, STIL and PLK4 are essential for effective directional cell motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs233973.
Published: 14 November 2019
...Shuwei Xie; Trey Farmer; Naava Naslavsky; Steve Caplan ABSTRACT The endocytic protein EHD1 plays an important role in ciliogenesis by facilitating fusion of the ciliary vesicle and removal of CP110 (also known as CCP110) from the mother centriole, as well as removal of Cep215 (also known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs228486.
Published: 03 October 2019
... extent as deletion of centrin 2. Phenotypic analysis of the 4DA mutant revealed defects in centrosome localization, centriole satellite assembly, ciliary assembly and function and in interactions with POC5 and SFI1. These observations indicate that centrin 2 requires calcium-binding capacity for its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs217521.
Published: 20 June 2019
... centriole. SAS-6 proteins are thought to constitute the hub of the cartwheel structure. However, the exact function of the cartwheel in the process of centriole formation has not been well characterized. In this study, we focused on the functions of human SAS-6 (HsSAS-6, also known as SASS6). By using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs228833.
Published: 20 February 2019
...Pierre Gönczy; Georgios N. Hatzopoulos ABSTRACT The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2514–2525.
Published: 01 July 2016
...Saroj Saurya; Hélio Roque; Zsofia A. Novak; Alan Wainman; Mustafa G. Aydogan; Adam Volanakis; Boris Sieber; David Miguel Susano Pinto; Jordan W. Raff ABSTRACT Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2437–2442.
Published: 15 July 2015
...Marco Gottardo; Giuliano Callaini; Maria Giovanna Riparbelli ABSTRACT We report, here, that two distinct centriole lineages exist in Drosophila : somatic centrioles usually composed by microtubule doublets and germ line centrioles characterized by triplets. Remarkably, the transition from doublets...
Journal Articles
J Cell Sci (2015) 128 (9): 1674–1682.
Published: 01 May 2015
...Lukas Čajánek; Timo Glatter; Erich A. Nigg Centrioles function as core components of centrosomes and as basal bodies for the formation of cilia and flagella. Thus, effective control of centriole numbers is essential for embryogenesis, tissue homeostasis and genome stability. In mammalian cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1294–1307.
Published: 01 April 2015
... plasticity. Although centrioles, cilia and flagella have cold-stable microtubules, MAP6 proteins have not been identified in these organelles, suggesting that additional proteins support this role in these structures. Here, we characterize human FAM154A (hereafter referred to as hSAXO1) as the first human...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4111–4122.
Published: 01 October 2014
.... For instance, the proteinaceous linker connecting parental centrioles has to move away to liberate the joint duplicated centrosomes for their timely separation at the onset of mitosis, and this process is partly dependent on the activity of Nek2A and Eg5. As the activities of both Nek2A and Eg5 are regulated...
Journal Articles
J Cell Sci (2014) 127 (19): 4128–4133.
Published: 01 October 2014
...Elif N. Firat-Karalar; Joshua Sante; Sarah Elliott; Tim Stearns ABSTRACT Centrioles are evolutionarily conserved microtubule-based structures at the core of the animal centrosome that are essential for nucleating the axoneme of cilia. We hypothesized that centriole proteins have been under...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2803–2810.
Published: 01 July 2014
...Chad G. Pearson ABSTRACT Centrioles and basal bodies (CBBs) are microtubule-rich cylindrical structures that nucleate and organize centrosomes and cilia, respectively. Despite their apparent ninefold rotational symmetry, the nine sets of triplet microtubules in CBBs possess asymmetries...