.... Published by The Company of Biologists Ltd 2018 Summary: The transmission of mechanical signals through cellular assemblies regulates collective cell behavior. Cell–cell junctions Mechanobiology Actin cytoskeleton Collective cell migration Active matter The ability of metazoan...

...Elaina B. Breznau; Megan Murt; T. Lynne Blasius; Kristen J. Verhey; Ann L. Miller ABSTRACT Centralspindlin, a complex of the kinesin-6-family member MKLP1 and MgcRacGAP (also known as Kif23 and Racgap1, respectively), is required for cytokinesis and cell–cell junctions. During anaphase...

... flotillin 1 and 2 as new partners of the cadherin complexes. We show that flotillins are localised at cell–cell junctions (CCJs) in a cadherin-dependent manner. Flotillins and cadherins are constitutively associated at the plasma membrane and their colocalisation at CCJ increases with CCJ maturation. Using...

... adhesion, although outside of defined junctional structures, can be recruited via β-catenin ( Ilan et al., 2000 ). The exact progression of cell–cell junction formation is still unresolved. However, one of the earliest events is the recruitment of nectins to adherens junctions ( Takai and Nakanishi...

...Xiao Peng; Laura E. Cuff; Cort D. Lawton; Kris A. DeMali Vinculin was identified as a component of adherens junctions 30 years ago, yet its function there remains elusive. Deletion studies are consistent with the idea that vinculin is important for the organization of cell-cell junctions. However...

... is migfilin, a widely expressed protein consisting of an N-terminal filamin-binding domain, a central proline-rich domain and three C-terminal LIM domains. Migfilin is recruited to cell-matrix contacts in response to adhesion and colocalizes with β-catenin at cell-cell junctions in epithelial and endothelial...

...Vasiliki Gkretsi; Yongjun Zhang; Yizeng Tu; Ka Chen; Donna B. Stolz; Yanqiang Yang; Simon C. Watkins; Chuanyue Wu Cell-cell junctions are essential for epithelial and endothelial tissue formation and communication between neighboring cells. We report here that migfilin, a recently identified...