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Keywords: Cell-cell adhesion
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Journal Articles
J Cell Sci (2020) 133 (6): jcs228031.
Published: 16 March 2020
.... , Asimaki , A. , Michaelson , J. E. , Plovie , E. , Macrae , C. A. , Saffitz , J. E. and Huang , H . ( 2014 ). Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion . Cardiovasc. Res.   104 , 280 - 289 . 10.1093/cvr...
Journal Articles
J Cell Sci (2019) 132 (18): jcs226753.
Published: 26 September 2019
.... It is also unclear how cellular forces, cellcell adhesion and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6084–6093.
Published: 15 December 2012
... kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-mediated cell-cell adhesion and segregation, important during normal developmental processes, and implicated in tumour neo-angiogenesis and metastasis. We previously...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (15): 2640–2648.
Published: 01 August 2010
... is dispensable for postnatal skeletal growth, it favors osteogenesis over adipogenesis. Deletion of either cadherin reduces β-catenin abundance and β-catenin-dependent gene expression, whereas N-cadherin loss disrupts cell-cell adhesion more severely than loss of cadherin 11. Thus, Cdh2 and Cdh11 are crucial...
Journal Articles
J Cell Sci (2009) 122 (7): 905–911.
Published: 01 April 2009
... the wound, a process that appears to depend on the formation of new cell–extracellular-matrix adhesions as cells spread into the wound. In direct contrast to scrape-wounded cells, isolated cells without cell-cell contacts failed to polarize, suggesting that asymmetry of cell-cell adhesions resulting from...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (7): 933–938.
Published: 01 April 2008
...Encarnación Lozano; Marieke A. M. Frasa; Katarzyna Smolarczyk; Ulla G. Knaus; Vania M. M. Braga E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3544–3552.
Published: 15 October 2007
... Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Finland 15 7 2007 © The Company of Biologists Limited 2007 2007 Cell-cell adhesion Hepatocyte growth factor Cell migration E-cadherin Despite significant advances in our understanding...
Journal Articles
J Cell Sci (2007) 120 (16): 2828–2837.
Published: 15 August 2007
... focal adhesions, but also for the actin reorganization at cell-cell contact sites and for correct cell-cell adhesion and, thus, for collective cell migration. Impairment of focal adhesions and stress fibers caused by ZRP-1 depletion has been associated with reduced tyrosine phosphorylation of FAK...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2944–2952.
Published: 15 August 2007
...-cell adhesion Epidermis Stem cell Syntenin © The Company of Biologists Limited 2007 2007 12 6 2007 * Author for correspondence (e-mail: fiona.watt@cancer.org.uk ) Syntenin is reported to be one of the genes that are highly upregulated in the reservoir of stem cells...
Journal Articles
J Cell Sci (2007) 120 (10): 1818–1828.
Published: 15 May 2007
...David M. Bryant; Markus C. Kerr; Luke A. Hammond; Shannon R. Joseph; Keith E. Mostov; Rohan D. Teasdale; Jennifer L. Stow In epithelia, junction proteins are endocytosed for modulation of cell-cell adhesion and cell polarity. In response to growth factors, the cell-cell adhesion protein E-cadherin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (1): 86–100.
Published: 01 January 2007
...Daisuke Yamazaki; Tsukasa Oikawa; Tadaomi Takenawa During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho-family small GTPases, which regulate actin dynamics, play pivotal roles in cadherin-dependent cell-cell adhesion; however...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (16): 3385–3398.
Published: 15 August 2006
.... * Author for correspondence (e-mail: moelling@immv.unizh.ch ) 28 4 2006 © The Company of Biologists Limited 2006 2006 AF6 isoform 3 F-actin-binding site E-cadherin Cell-cell adhesion Collective cell migration Directionality AF6 is a tumor-suppressor-like protein that has...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (24): 5743–5754.
Published: 15 December 2005
...David R. Garrod; Mohamed Y. Berika; William F. Bardsley; David Holmes; Lydia Tabernero The resistance of tissues to physical stress is dependent upon strong cell-cell adhesion in which desmosomes play a crucial role. We propose that desmosomes fulfil this function by adopting a more strongly...
Journal Articles
J Cell Sci (2005) 118 (20): 4901–4912.
Published: 15 October 2005
...) and the phosphatase PTEN as analysed in PANC-1 and Smad4-deficient BxPC-3 pancreatic carcinoma cells. TGFβ 1 treatment enhanced tyrosine phosphorylation of α- and β-catenin, which resulted in dissociation of the E-cadherin/catenin complex from the actin cytoskeleton and reduced cell-cell adhesion. The PI3-kinase...
Journal Articles
J Cell Sci (2005) 118 (17): 3883–3894.
Published: 01 September 2005
... compaction. Based on our results we propose that a vimentin-based classical cadherin complex functions together with the actin-based complex to promote strong cell-cell adhesion in fibroblasts. ‡ Author for correspondence (e-mail: knudsenk@mlhs.org ) * Present address: Georgetown University...
Journal Articles
J Cell Sci (2004) 117 (13): 2853–2864.
Published: 01 June 2004
... of Biologists Limited 2004 2004 Cell-cell adhesion Mesenchymal differentiation Cadherins Adipogenesis Transgenic mice Cadherins are a family of integral transmembrane proteins that mediate calcium-dependent cell-cell adhesion, a process necessary for cell aggregation and sorting during tissue...
Journal Articles
J Cell Sci (2003) 116 (18): 3687–3700.
Published: 15 September 2003
.... Overexpression of Bcl-2 has been associated with the loss of contact inhibition, unregulated growth and foci formation in culture. In this study, we have examined the effects of bcl-2 overexpression and expression on cell-cell adhesion in MCF-7 and MDCK epithelial cell lines respectively. Overexpression of Bcl-2...
Journal Articles
J Cell Sci (2002) 115 (7): 1391–1402.
Published: 01 April 2002
...Sirpa Aho; Laura Levänsuo; Outi Montonen; Csaba Kari; Ulrich Rodeck; Jouni Uitto P120 catenin (p120ctn) belongs to the Armadillo family of proteins, which is implicated in cell-cell adhesion and signal transduction. Owing to alternative splicing and multiple translation initiation codons, several...
Journal Articles
J Cell Sci (2001) 114 (18): 3265–3272.
Published: 15 September 2001
...John D. Whittard; Steven K. Akiyama Integrin receptor activation is an important regulatory mechanism for cell-substrate and cell-cell adhesion. In this study, we explore a signaling pathway activated by mAb 12G10, an antibody that can activate β 1 integrins and induce integrin-mediated cell-cell...