... dynamics, increased glycolysis and vasodilation via increased eNOS activity. Cell–cell adhesion Mechanotransduction VE-cadherin National Institutes of Health https://doi.org/10.13039/100000002 R35GM136291 P30CA086862 University of Iowa https://doi.org/10.13039/100008893...

... epithelial cells remain poorly understood. Here, we manipulated the density of mammary epithelial cells in culture, which led to several mitotic defects. Perturbation of cell–cell adhesion formation impairs the dynamics of the plasma membrane, affecting the shape and size of mitotic cells and resulting...

...Gillian DeWane; Nicholas M. Cronin; Logan W. Dawson; Christy Heidema; Kris A. DeMali ABSTRACT Vinculin is an actin-binding protein present at cell–matrix and cell–cell adhesions, which plays a critical role in bearing force experienced by cells and dissipating it onto the cytoskeleton. Recently, we...

.... Acid-base transport Cell polarity Cell–cell adhesion Scribble complex Primary cilium Mitosis Danmarks Frie Forskningsfond http://dx.doi.org/10.13039/501100011958 0135-0139B Finely tuned regulation of the subcellular localization of ion transport proteins is vital for tissue...

... of Biologists Ltd 2020 Summary: A review of the roles of intermediate filaments and desmosomes in mechanobiology, highlighting their integration with other cytoskeletal and adhesive systems. Mechanotransduction Cadherin Cytoskeleton Cell–cell adhesion Desmosome Intermediate filaments...

.... It is also unclear how cellular forces, cell–cell adhesion and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers...

...Nivetha Kannan; Vivian W. Tang ABSTRACT Actomyosin II contractility in epithelial cell plays an essential role in tension-dependent adhesion strengthening. One key unsettling question is how cellular contraction transmits force to the nascent cell–cell adhesion when there is no stable attachment...

... (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes. Slit–Robo GAP Brain evolution srGAP2 C. elegans Cell–cell adhesion Contact inhibition National Institutes...

... at cell–cell adhesions and that KIF17 depletion inhibits accumulation of actin at the apical pole of cells grown in 3D organotypic cultures and alters the distribution of actin and E-cadherin in cells cultured in 2D on solid supports. Overexpression of full-length KIF17 constructs or truncation mutants...

... viruses to cross the epithelial barrier. However, viruses have developed multiple strategies to blaze their path through the epithelium by utilizing components of cell–cell adhesion structures as receptors. In this Commentary, we discuss how viruses take advantage of the apical junction complex to spread...

... stem cells Cell–cell adhesion Adherens junctions Smooth muscle cells Differentiation Vascular contractility Cell–cell adhesion is mediated through the interaction of cell adhesion molecules (CAMs), including cadherins, integrins, selectins and immunoglobulin-like CAMs. These CAMs regulate...

... kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-mediated cell-cell adhesion and segregation, important during normal developmental processes, and implicated in tumour neo-angiogenesis and metastasis. We previously...

...Wenting Shih; Soichiro Yamada Summary Cancer cells that originate from epithelial tissues typically lose epithelial specific cell–cell junctions, but these transformed cells are not devoid of cell–cell adhesion proteins. Using hepatocyte-growth-factor-treated MDCK cells that underwent a complete...

... the involvement of radixin in these processes. Here we show that radixin is required for migration of PC3 prostate cancer cells, and that radixin, but not ezrin or moesin, depletion by RNA interference increases cell spread area and cell–cell adhesion mediated by adherens junctions. Radixin depletion also alters...

...Andrew H. Jheon; Pasha Mostowfi; Malcolm L. Snead; Rebecca A. Ihrie; Eli Sone; Tiziano Pramparo; Laura D. Attardi; Ophir D. Klein Little is known about the role of cell–cell adhesion in the development of mineralized tissues. Here we report that PERP, a tetraspan membrane protein essential...

... is dispensable for postnatal skeletal growth, it favors osteogenesis over adipogenesis. Deletion of either cadherin reduces β-catenin abundance and β-catenin-dependent gene expression, whereas N-cadherin loss disrupts cell-cell adhesion more severely than loss of cadherin 11. Thus, Cdh2 and Cdh11 are crucial...

... the wound, a process that appears to depend on the formation of new cell–extracellular-matrix adhesions as cells spread into the wound. In direct contrast to scrape-wounded cells, isolated cells without cell-cell contacts failed to polarize, suggesting that asymmetry of cell-cell adhesions resulting from...

...Encarnación Lozano; Marieke A. M. Frasa; Katarzyna Smolarczyk; Ulla G. Knaus; Vania M. M. Braga E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis...

.... The control cMDCK clone shows reduced cell-cell adhesion and has a spindle-shape morphology upon treatment with HGF. By contrast, TS12-4 and TS12-22 still form epithelial-like colonies after 16 hours of incubation with HGF. A MDCK clone that expresses a catalytically inactive mutant version of ADAMTS12 (TS12...

...-mail: [email protected] ) 12 6 2007 © The Company of Biologists Limited 2007 2007 Delta Cell-cell adhesion Epidermis Stem cell Syntenin The epidermis, which forms the outer covering of mammalian skin, is maintained throughout life by proliferation of stem cells...