... in intermediate filament and desmosome networks result in both chronic and acquired diseases. * Authors for correspondence ( kgreen@northwestern.edu ; joshua.broussard@northwestern.edu ) Mechanotransduction Cadherin Cytoskeleton Cell–cell adhesion Desmosome Intermediate filaments...

.... It is also unclear how cellular forces, cell–cell adhesion and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers...

...Nivetha Kannan; Vivian W. Tang ABSTRACT Actomyosin II contractility in epithelial cell plays an essential role in tension-dependent adhesion strengthening. One key unsettling question is how cellular contraction transmits force to the nascent cell–cell adhesion when there is no stable attachment...

... (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes. Slit–Robo GAP Brain evolution srGAP2 C. elegans Cell–cell adhesion Contact inhibition As cells migrate, change...

... at cell–cell adhesions and that KIF17 depletion inhibits accumulation of actin at the apical pole of cells grown in 3D organotypic cultures and alters the distribution of actin and E-cadherin in cells cultured in 2D on solid supports. Overexpression of full-length KIF17 constructs or truncation mutants...

... viruses to cross the epithelial barrier. However, viruses have developed multiple strategies to blaze their path through the epithelium by utilizing components of cell–cell adhesion structures as receptors. In this Commentary, we discuss how viruses take advantage of the apical junction complex to spread...

... cadherin-11 in SMC function in vivo . This is the first study implicating cadherin-11 in MSC differentiation into SMCs and in the development of contractile function in vitro and in vivo . Our findings show that cadherin-11 – but not cadherin-2 – is the key regulator of cell–cell-adhesion-induced...

... kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-mediated cell-cell adhesion and segregation, important during normal developmental processes, and implicated in tumour neo-angiogenesis and metastasis. We previously...

...Wenting Shih; Soichiro Yamada Summary Cancer cells that originate from epithelial tissues typically lose epithelial specific cell–cell junctions, but these transformed cells are not devoid of cell–cell adhesion proteins. Using hepatocyte-growth-factor-treated MDCK cells that underwent a complete...

... the involvement of radixin in these processes. Here we show that radixin is required for migration of PC3 prostate cancer cells, and that radixin, but not ezrin or moesin, depletion by RNA interference increases cell spread area and cell–cell adhesion mediated by adherens junctions. Radixin depletion also alters...

...Andrew H. Jheon; Pasha Mostowfi; Malcolm L. Snead; Rebecca A. Ihrie; Eli Sone; Tiziano Pramparo; Laura D. Attardi; Ophir D. Klein Little is known about the role of cell–cell adhesion in the development of mineralized tissues. Here we report that PERP, a tetraspan membrane protein essential...

... is dispensable for postnatal skeletal growth, it favors osteogenesis over adipogenesis. Deletion of either cadherin reduces β-catenin abundance and β-catenin-dependent gene expression, whereas N-cadherin loss disrupts cell-cell adhesion more severely than loss of cadherin 11. Thus, Cdh2 and Cdh11 are crucial...

... the wound, a process that appears to depend on the formation of new cell–extracellular-matrix adhesions as cells spread into the wound. In direct contrast to scrape-wounded cells, isolated cells without cell-cell contacts failed to polarize, suggesting that asymmetry of cell-cell adhesions resulting from...

...Encarnación Lozano; Marieke A. M. Frasa; Katarzyna Smolarczyk; Ulla G. Knaus; Vania M. M. Braga E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis...

... that ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme. Cell-cell adhesion Hepatocyte growth factor Cell migration E-cadherin Male adult severe combined immunodeficient mice (SCID; C.B-17/IcrCrl-scid-BR) were obtained from Charles River Laboratories...

... focal adhesions, but also for the actin reorganization at cell-cell contact sites and for correct cell-cell adhesion and, thus, for collective cell migration. Impairment of focal adhesions and stress fibers caused by ZRP-1 depletion has been associated with reduced tyrosine phosphorylation of FAK...

... instructions (InVitrogen) and analysed 48 hours after transfection. * Author for correspondence (e-mail: fiona.watt@cancer.org.uk ) 12 6 2007 © The Company of Biologists Limited 2007 2007 Delta Cell-cell adhesion Epidermis Stem cell Syntenin The epidermis, which forms...

...David M. Bryant; Markus C. Kerr; Luke A. Hammond; Shannon R. Joseph; Keith E. Mostov; Rohan D. Teasdale; Jennifer L. Stow In epithelia, junction proteins are endocytosed for modulation of cell-cell adhesion and cell polarity. In response to growth factors, the cell-cell adhesion protein E-cadherin...

...Daisuke Yamazaki; Tsukasa Oikawa; Tadaomi Takenawa During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho-family small GTPases, which regulate actin dynamics, play pivotal roles in cadherin-dependent cell-cell adhesion; however...

... The Company of Biologists Limited 2006 2006 AF6 isoform 3 F-actin-binding site E-cadherin Cell-cell adhesion Collective cell migration Directionality AF6-knockout mice have impaired cell junctions during embryogenesis ( Ikeda et al., 1999 ; Zhadanov et al., 1999 ). AF6 is localized...