... dynamics, increased glycolysis and vasodilation via increased eNOS activity. Cell–cell adhesion Mechanotransduction VE-cadherin National Institutes of Health https://doi.org/10.13039/100000002 R35GM136291 P30CA086862 University of Iowa https://doi.org/10.13039/100008893...

... epithelial cells remain poorly understood. Here, we manipulated the density of mammary epithelial cells in culture, which led to several mitotic defects. Perturbation of cell–cell adhesion formation impairs the dynamics of the plasma membrane, affecting the shape and size of mitotic cells and resulting...

...Gillian DeWane; Nicholas M. Cronin; Logan W. Dawson; Christy Heidema; Kris A. DeMali ABSTRACT Vinculin is an actin-binding protein present at cell–matrix and cell–cell adhesions, which plays a critical role in bearing force experienced by cells and dissipating it onto the cytoskeleton. Recently, we...

... Biol. 51 , 124 - 131 . 10.1016/j.ceb.2018.03.004 Nakagawa , M. , Fukata , M. , Yamaga , M. , Itoh , N. and Kaibuchi , K. ( 2001 ). Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites . J. Cell Sci. 114 , 1829...

... representations of the indicated filamentous cytoskeletons and associated cell–cell adhesive complexes, as well as an overlay to illustrate their interconnected nature. Gray outlines represent cell–cell junctional areas and ovals represent nuclei. Images supplied by the laboratory of K.J.G. Fig. 1. Architecture...

.... It is also unclear how cellular forces, cell–cell adhesion and velocities are coordinated within streams. To independently tune stiffness and collagen fiber length, we developed new hydrogels and discovered invasion-like streaming of normal epithelial cells on soft substrates coated with long collagen fibers...

...Nivetha Kannan; Vivian W. Tang ABSTRACT Actomyosin II contractility in epithelial cell plays an essential role in tension-dependent adhesion strengthening. One key unsettling question is how cellular contraction transmits force to the nascent cell–cell adhesion when there is no stable attachment...

... (srGAPs), which are highly conserved proteins that interact with the plasma membrane, regulate Rho family GTPases, and function in a wide range of cell biological processes. Slit–Robo GAP Brain evolution srGAP2 C. elegans Cell–cell adhesion Contact inhibition National Institutes...

... at cell–cell adhesions and that KIF17 depletion inhibits accumulation of actin at the apical pole of cells grown in 3D organotypic cultures and alters the distribution of actin and E-cadherin in cells cultured in 2D on solid supports. Overexpression of full-length KIF17 constructs or truncation mutants...

... viruses to cross the epithelial barrier. However, viruses have developed multiple strategies to blaze their path through the epithelium by utilizing components of cell–cell adhesion structures as receptors. In this Commentary, we discuss how viruses take advantage of the apical junction complex to spread...

... Lee   M. H. , Padmashali   R. , Koria   P. , Andreadis   S. T. ( 2011 ). JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion.   FASEB J.   25 , 613 – 623 . 10.1096/fj.10--161380 Li   L. , Bennett   S. A. , Wang   L. ( 2012 ). Role of E...

... kinases of the erbB and Eph families. ADAM10-mediated cleavage of ephrins, the ligands for Eph receptors, is suggested to control Eph/ephrin-mediated cell-cell adhesion and segregation, important during normal developmental processes, and implicated in tumour neo-angiogenesis and metastasis. We previously...

...Wenting Shih; Soichiro Yamada Summary Cancer cells that originate from epithelial tissues typically lose epithelial specific cell–cell junctions, but these transformed cells are not devoid of cell–cell adhesion proteins. Using hepatocyte-growth-factor-treated MDCK cells that underwent a complete...

... the involvement of radixin in these processes. Here we show that radixin is required for migration of PC3 prostate cancer cells, and that radixin, but not ezrin or moesin, depletion by RNA interference increases cell spread area and cell–cell adhesion mediated by adherens junctions. Radixin depletion also alters...

...Andrew H. Jheon; Pasha Mostowfi; Malcolm L. Snead; Rebecca A. Ihrie; Eli Sone; Tiziano Pramparo; Laura D. Attardi; Ophir D. Klein Little is known about the role of cell–cell adhesion in the development of mineralized tissues. Here we report that PERP, a tetraspan membrane protein essential...

... is dispensable for postnatal skeletal growth, it favors osteogenesis over adipogenesis. Deletion of either cadherin reduces β-catenin abundance and β-catenin-dependent gene expression, whereas N-cadherin loss disrupts cell-cell adhesion more severely than loss of cadherin 11. Thus, Cdh2 and Cdh11 are crucial...

... the wound, a process that appears to depend on the formation of new cell–extracellular-matrix adhesions as cells spread into the wound. In direct contrast to scrape-wounded cells, isolated cells without cell-cell contacts failed to polarize, suggesting that asymmetry of cell-cell adhesions resulting from...

...Encarnación Lozano; Marieke A. M. Frasa; Katarzyna Smolarczyk; Ulla G. Knaus; Vania M. M. Braga E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis...

... Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, Finland 15 7 2007 © The Company of Biologists Limited 2007 2007 Cell-cell adhesion Hepatocyte growth factor Cell migration E-cadherin The human ADAMTS family comprises 19 structurally...

... focal adhesions, but also for the actin reorganization at cell-cell contact sites and for correct cell-cell adhesion and, thus, for collective cell migration. Impairment of focal adhesions and stress fibers caused by ZRP-1 depletion has been associated with reduced tyrosine phosphorylation of FAK...