...Yuki Hatoyama; Yuta Homma; Shu Hiragi; Mitsunori Fukuda ABSTRACT Two small GTPases, Rab1 and Rab5, are key membrane trafficking regulators that are conserved in all eukaryotes. They have recently been found to be essential for cell survival and/or growth in cultured mammalian cells, thereby...

.... Wnt-stimulated β-catenin–TCF complex accumulation in the nucleus regulates cell survival, proliferation and differentiation through the transcription of target genes. Compared with their levels in G1, activation of the receptor LRP6 and cytosolic β-catenin are both upregulated in G2 cells. However...

...-mediated mechanism for the regulation of AMPK through a purinergic signaling pathway. Furthermore, we define AMPK as a pivotal molecule that underlies the regulatory effects of hemichannels on cell survival. * Author for correspondence ( yao@yamanashi.ac.jp ) Competing interests The authors...

... cell survival and drug resistance. In conclusion, phosphorylation of INrf2 by PKCε leads to regulation of Nrf2, with significant implications for the survival of cancer cells, which often express lower levels of PKCε. * Author for correspondence ( ajaiswal@som.umaryland.edu ) 20 09 2013...

... overrepresented signaling pathways. Among the human orthologs present in our data set, FEN1 and TSG101 regulate DNA repair and endocytosis, respectively, and also share common interacting partners with RhoA. We further demonstrate that FEN1, but not TSG101, regulates cell survival, MAPK p38 phosphorylation, RhoA...

... in the platelet-derived growth factor (PDGF)-induced activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling for cell survival. This complex was associated with PDGF receptor on the plasma membrane at cell-cell adhesion sites. Thus, the nectin-afadin complex is involved in PDGF-induced cell survival...

...Xueqian Yin; Songying Ouyang; Wenming Xu; Xiaopeng Zhang; Kin Lam Fok; Hau Yan Wong; Jiaping Zhang; Xiaobo Qiu; Shiying Miao; Hsiao Chang Chan; Linfang Wang Müllerian inhibiting substance (MIS) has recently been implicated in multiple cellular functions including promotion of cell survival...

... not directly related to matrix adhesion. For example, integrins have been found to control surface distribution and activity of N-cadherin during migration ( Monier-Gavelle and Duband, 1997 ). Integrins are also involved in maintenance of cell survival ( Crump et al., 2004 ; Haack and Hynes, 2001 ; Testaz...

...-5 increased cell survival and decreased apoptosis, as indicated by decreased caspase-3 activity and cell surface annexin V binding. Further examination of apoptotic pathways revealed that wt- and mutIGFBP-5 ameliorated the increase in caspase-9 but not the modest increase in caspase-8 during...

... (p75 NTR ) Ceramide Caspase activation Cell survival Otic vesicle Ceramide-1-phosphate Programmed cell death is a critical process for normal development and tissue homeostasis ( Glücksmann,1951 ; Raff, 1992 ; Jacobson et al., 1997 ; Vaux and Korsmeyer, 1999 ). Although the basic...

... 1994 by Company of Biologists 1994 cell death cell survival cell cycle phosphoprotein phosphatase adenosine 3′,5′ cyclic monophosphate (cAMP) Cell death has been considered to be either necrotic or apoptotic ( Kerr et al., 1972 ; Wyllie et al., 1980 ). In necrosis rapid damage...