...-binding proteins. These findings highlight the pivotal role of RAN1 in modulating pollen size and development, providing valuable insights into cell size regulation. * These authors contributed equally to this work Authors for correspondence ( [email protected] ; [email protected]...

... of dynein heavy chain 1 confirms that dynein has roles in axonal growth regulation, including axon length sensing, retrograde injury signaling and nerve regeneration. Dynein heavy chain Axonal transport Length sensing Cell size Neurodegeneration Agence Nationale de la Recherche http...

...Thom M. Molenaar; Muddassir Malik; Joana Silva; Ning Qing Liu; Judith H. I. Haarhuis; Christina Ambrosi; Eliza Mari Kwesi-Maliepaard; Tibor van Welsem; Tuncay Baubec; William J. Faller; Fred van Leeuwen ABSTRACT Cell size varies between cell types but is tightly regulated by cell intrinsic...

...Yuki Hara ABSTRACT The size of the intracellular structure that encloses genomic DNA – known as the nucleus in eukaryotes and nucleoid in prokaryotes – is believed to scale according to cell size and genomic content inside them across the tree of life. However, an actual scaling relationship...

..., requires minimal sample preparation, and applies to a wide range of biological and experimental conditions. The method can be used to track single-cell volume dynamics over arbitrarily long time periods. For HT1080 fibrosarcoma cells, we observe that the cell size at division is positively correlated...

... into the role of CLUH on mitochondrial energy production and cellular metabolism, we have generated CLUH-knockout cells using CRISPR/Cas9. Mitochondrial clustering was associated with a smaller cell size and with decreased abundance of respiratory complexes, resulting in oxidative phosphorylation (OXPHOS...

...-independent function of Slp2-a in the control of renal cell size through a previously uncharacterized C2B domain. We found that by recruiting Rap1 GAPs to the plasma membrane of MDCK II cells through the C2B domain, Slp2-a inactivates Rap signaling and modulates the size of the cells. Functional ablation...

... phosphorylation by TORC1 also responds to availability of glucose and is inhibited by osmotic and oxidative stresses. Rapamycin inhibits the ability of TORC1 to phosphorylate Rps6, owing to interaction of the rapamycin-FKBP12 complex with the FRB domain in Tor2. Rapamycin also leads to a decrease in cell size...

...-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. Development 134 , 211 -222. Ruvinsky, I. and Meyuhas, O. ( 2006 ). Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci. 6 , 342 -348. Sancho...

...Carmen M. Coelho; Sally J. Leevers ABSTRACT Studies in yeast have provided some clues to how cell size might be determined in unicellular eukaryotes; yet little attention has been paid to this issue in multicellular organisms. Reproducible cell sizes might be achieved in the dividing cells...

... that a single nuclear division is sufficient to activate septum formation, provided a critical cell size has been attained. In mitotic mutants and wild-type cells, delays in nuclear division resulted in the misplacement of the first septum. These results strongly support the role of mitotic nuclei...

... initiation was 13%. As there is also a substantial variability of G 2 (the coefficient of variation was estimated to be 38%), the combination of these data indicates that cell size regulation of G 2 contributes to maintaining cell size variability (and therefore DNA concentration) within certain limits...