.... Summary: The regulation of protein synthesis is altered in many cancers. This article discusses the role of translation initiation in cancer, including recent advances detailing new targets and therapeutic opportunities. Cancer Cell signalling Translation In healthy cells, control...

..., 2001 ; Schatteman et al., 1996 ; Belaguli et al., 1999 ; Bennett et al., 2016 ). Vascular smooth muscle cell Cellular reprogramming Cell signalling Stem cells Revascularisation Summary: The RNA-binding protein QKI isoforms hold key roles in alternative splicing facilitating...

.../dbio.1997.8566 Freeman   S. D. , Moore   W. M. , Guiral   E. C. , Holme   A. D. , Turnbull   J. E. , Pownall   M. E. ( 2008 ). Extracellular regulation of developmental cell signaling by XtSulf1.   Dev. Biol.   320 , 436 – 445 . 10.1016/j.ydbio.2008.05.554 Gilchrist...

.... 10 03 2014 12 03 2014 © 2014. Published by The Company of Biologists Ltd 2014 Cell signalling Cell migration NADPH oxidase Neutrophil Rho GEF Small GTPase Rac proteins (Rac1, Rac2 and Rac3), a subgroup within the Rho family of small GTPases, regulate key aspects...

... that are implicated in cell adhesion, cell polarity and migration. Increasing evidence suggests that the regulation of cell signalling and the cytoskeleton by ERM proteins is crucial during cancer progression. Thus, both their expression levels and subcellular localisation would affect tumour progression. High...

...Kevin A. Janes; Douglas A. Lauffenburger Summary Computational models of cell signalling are perceived by many biologists to be prohibitively complicated. Why do math when you can simply do another experiment? Here, we explain how conceptual models, which have been formulated mathematically, have...

...Madhu Mahankali; Karen M. Henkels; Julian Gomez-Cambronero Summary Phospholipase D2 (PLD2) is a cell-signaling molecule that bears two activities: a guanine-nucleotide exchange factor (GEF) and a lipase that reside in the PX/PH domains and in two HKD domains, respectively. Upon cell stimulation...

... on phosphoinositides and controlled by PDK1 and PLCγ1. * Author for correspondence ( m.falasca@qmul.ac.uk ) 20 2 2012 © 2012. Published by The Company of Biologists Ltd 2012 Cell invasion Cell signalling 3-Phosphoinositide-dependent protein kinase-1 Phosphoinositide 3-kinase Phospholipase...

...Stephen W. G. Tait; Douglas R. Green Mitochondria have long been considered as crucial organelles, primarily for their roles in biosynthetic reactions such as ATP synthesis. However, it is becoming increasingly apparent that mitochondria are intimately involved in cell signalling pathways...

... for correspondence (e-mail: c.j.z.richardson@dundee.ac.uk ) 30 11 2007 © The Company of Biologists Limited 2008 2008 Cell signalling Kinase OSR1 SPAK WNK1 Cotransporter The STE20/SPS1-related proline/alanine-rich kinase (SPAK, STK39) and oxidative-stress-responsive kinase-1 (OSR1...

... GLUT4 Glucose Insulin Intracellular trafficking AS160 Cell signalling Rab protein Scaffold protein Insulin regulates uptake of glucose into adipose tissue and muscle by promoting the rapid translocation of the insulin-responsive isoform of the glucose transporter, GLUT4, from...

... to investigate exosomes released by HepG2 and K562 cells into culture medium. TfR2, CD81 and to a lesser extent caveolin-1, were found to be part of the exosomal budding vesicles. In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling...

.... * Author for correspondence (e-mail: steinber@id.wustl.edu ) 16 10 2003 © The Company of Biologists Limited 2004 2004 Calcium waves Gap junctions Cell signalling Connexin Gap junctional communication allows cells to share information in the form of aqueous solutes...

...-mail: pears@bioch.ox.ac.uk ) * Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK 6 5 2003 © The Company of Biologists Limited 2003 2003 Superoxide Cell signalling Dictyostelium discoideum Superoxide dismutase Eukaryotic organisms...