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Keywords: Cell signalling
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Journal Articles
J Cell Sci (2021) 134 (1): jcs248476.
Published: 13 January 2021
... and therapeutic opportunities. Cancer Cell signalling Translation In healthy cells, control of translation initiation is required for homeostasis, which is mediated through the production of key proteins that underpin essential cellular processes. In contrast, malignant cells ‘hijack...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230276.
Published: 15 August 2019
... QKI isoforms hold key roles in alternative splicing facilitating the production of vascular cells for therapy and disease modelling. Vascular smooth muscle cell Cellular reprogramming Cell signalling Stem cells Revascularisation Cardiovascular disease (CVD) is the leading cause...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1408–1421.
Published: 1 April 2015
... Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Morphogen Development Cell signalling Pronephros 6-O-endosulfatase Heparan sulfate HSPG Wnt...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2589–2600.
Published: 1 June 2014
... GEFs are associated with disease initiation and/or progression ( Berger et al., 2012 ; Hodis et al., 2012 ; Lindsay et al., 2011 ; Nishihara et al., 2002 ; Sanz-Moreno et al., 2008 ). Cell signalling Cell migration NADPH oxidase Neutrophil Rho GEF Small GTPase © 2014. Published...
Journal Articles
J Cell Sci (2014) 127 (2): 267–275.
Published: 15 January 2014
... that are implicated in cell adhesion, cell polarity and migration. Increasing evidence suggests that the regulation of cell signalling and the cytoskeleton by ERM proteins is crucial during cancer progression. Thus, both their expression levels and subcellular localisation would affect tumour progression. High...
Journal Articles
J Cell Sci (2013) 126 (9): 1913–1921.
Published: 1 May 2013
...Kevin A. Janes; Douglas A. Lauffenburger Summary Computational models of cell signalling are perceived by many biologists to be prohibitively complicated. Why do math when you can simply do another experiment? Here, we explain how conceptual models, which have been formulated mathematically, have...
Journal Articles
J Cell Sci (2013) 126 (6): 1416–1428.
Published: 15 March 2013
...Madhu Mahankali; Karen M. Henkels; Julian Gomez-Cambronero Summary Phospholipase D2 (PLD2) is a cell-signaling molecule that bears two activities: a guanine-nucleotide exchange factor (GEF) and a lipase that reside in the PX/PH domains and in two HKD domains, respectively. Upon cell stimulation...
Journal Articles
J Cell Sci (2012) 125 (13): 3153–3163.
Published: 1 July 2012
... activation through an intermediate, PI3K-dependent effector. Cell invasion Cell signalling 3-Phosphoinositide-dependent protein kinase-1 Phosphoinositide 3-kinase Phospholipase Cγ1 © 2012. Published by The Company of Biologists Ltd 2012 20 2 2012 * Author for correspondence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 807–815.
Published: 15 February 2012
...Stephen W. G. Tait; Douglas R. Green Mitochondria have long been considered as crucial organelles, primarily for their roles in biosynthetic reactions such as ATP synthesis. However, it is becoming increasingly apparent that mitochondria are intimately involved in cell signalling pathways...
Journal Articles
J Cell Sci (2008) 121 (5): 675–684.
Published: 1 March 2008
... and localization of the WNK1 protein kinase by hyperosmotic stress. J. Cell Biol. 176 , 89 -100. * Author for correspondence (e-mail: c.j.z.richardson@dundee.ac.uk ) 30 11 2007 © The Company of Biologists Limited 2008 2008 Cell signalling Kinase OSR1 SPAK WNK1 Cotransporter...
Journal Articles
J Cell Sci (2007) 120 (23): 4197–4208.
Published: 1 December 2007
... 13 9 2007 © The Company of Biologists Limited 2007 2007 Rip11 GLUT4 Glucose Insulin Intracellular trafficking AS160 Cell signalling Rab protein Scaffold protein Insulin regulates uptake of glucose into adipose tissue and muscle by promoting the rapid translocation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4486–4498.
Published: 1 November 2006
... to investigate exosomes released by HepG2 and K562 cells into culture medium. TfR2, CD81 and to a lesser extent caveolin-1, were found to be part of the exosomal budding vesicles. In conclusion, the present study indicates that TfR2 localizes in LDTI microdomains, where it promotes cell signalling...
Journal Articles
J Cell Sci (2004) 117 (6): 881–887.
Published: 22 February 2004
... 2003 © The Company of Biologists Limited 2004 2004 Calcium waves Gap junctions Cell signalling Connexin Gap junctional communication allows cells to share information in the form of aqueous solutes, and to respond to signals as a group rather than as individuals. The coordination...
Journal Articles
J Cell Sci (2003) 116 (16): 3387–3397.
Published: 15 August 2003
... Superoxide Cell signalling Dictyostelium discoideum Superoxide dismutase Eukaryotic organisms employ sophisticated signalling networks to organise cellular functions. These consist of proteins with specialised enzyme activities and binding affinities, as well as smaller freely diffusible ions...