... by multiple stem cell niche-derived cues. We present here recent research and perspectives on how niche signals promote MuSC quiescence. Muscle Muscle stem cell Stem cell niche Quiescence Cell adhesion Cell signaling National Institute of Arthritis and Musculoskeletal and Skin Diseases...

...: The Nir2 and Nir3 lipid transfer proteins maintain phosphoinositide signaling and actin dynamics, supporting effective phagocytosis. Immunity Cytoskeleton Lipid transfer Membrane contact sites Cell signaling Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung...

... of Biologists Ltd 2020 Summary: Clathrin-mediated endocytosis can be inhibited by mechanical factors leading to the formation of frustrated clathrin-coated structures that can fulfill new functions. Clathrin Endocytosis Mechanics Mechanobiology Actin Cell signaling Gustave Roussy...

... they contribute to disease development. Ubiquitin HECT E3 ubiquitin ligase Ubiquitylation Protein-protein interactions Protein turnover Cell signaling Cancer Neurological disorders Neurodevelopmental disorders Neurodegeneration National Institutes of Health 10.13039/100000002...

..., which are required for spontaneous cell migration. Cell signaling Ras GTPase Phosphatidylinositol lipid Excitable system Self-organization Spontaneous migration Symmetry breaking underlies essential cellular decision-making processes, including polarization, migration and division...

.... T cell receptor TCR Cellular immune response Cytoskeleton Cell adhesion Cell signaling Adaptor protein ADAP SLP-76 Microcluster Confocal microscopy American Heart Association 10.13039/100000968 0635546T National Institutes of Health 10.13039/100000002 R01...

...Steven L. Gonias; Michael A. Banki; Andrew S. Gilder; Pardis Azmoon; Wendy M. Campana; Elisabetta Mantuano ABSTRACT The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells...

...   303 , 1007 - 1010 . 10.1126/science.1093133 Sager , R. and Lee , J.-Y. ( 2014 ). Plasmodesmata in integrated cell signalling: insights from development and environmental signals and stresses . J. Exp. Bot.   65 , 6337 - 6358 . 10.1093/jxb/eru365 Schoelz , J. E...

... of Biologists Ltd 2016 Src kinase was blocked by incubating cells with 10 μM PP2 (Calbiochem, UK) for 30 min, prior to mechanical measurements. PI3K was inhibited by treating cells with 50 μM LY294002 (Cell Signaling Technologies, Boston, MA) or with 5 nM Wortmannin (Santa Cruz Biotechnology, CA) for 1 h...

... in response to thapsigargin, STIM1L mediates SOCE and ER refilling at least as efficiently as the classical isoform. Calcium signaling Cell signaling Electron microscopy Ion channels Muscle physiology Store‐operated Ca 2+ entry (SOCE) is an evolutionarily conserved signaling mechanism...

... approaches. Although the involvement of AURA in the cell cycle and cell division is well established, a non-mitotic role for AURA in other cell signaling pathways, such as cancer cell migration and adhesion, has been recently shown ( Do et al., 2014 ). Besides its well-defined role in mitosis...

...Guo-Lei Zhou; Haitao Zhang; Huhehasi Wu; Pooja Ghai; Jeffrey Field ABSTRACT Cell signaling can control the dynamic balance between filamentous and monomeric actin by modulating actin regulatory proteins. One family of actin regulating proteins that controls actin dynamics comprises cyclase...

... ) Competing interests The authors declare no competing interests. 14 03 2013 4 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Cancer Cell signaling Nuclear transport Wnt pathway The Wnt–β-catenin pathway is a major signaling route that controls embryonic...

.... Published by The Company of Biologists Ltd 2014 Cerebral cavernous malformations CCM Cell signaling KRIT1 PCDC10 Rho Signaling Vascular biology Cerebral cavernous malformations (CCMs) consist of clusters of enlarged endothelial channels (‘caverns’) that are arranged back-to-back...

..., with large impact on our understanding of immunity in health and disease. * Author for correspondence ( [email protected] ) © 2013. Published by The Company of Biologists Ltd 2013 CD31 T-lymphocyte PECAM-1 MHC tolerance Cell signaling Trafficking However, the importance...

... that the few Dmon1 mut4 homozygous flies that escaped to the adult stage did not display any obvious patterning defects. This suggests that cell signalling during pattern formation is not affected. This conclusion was confirmed when we monitored the expression of target genes of several signalling pathways...

... 2013. Published by The Company of Biologists Ltd 2013 Microtubule Macroautophagy Phagocytosis Phagophore Cell signaling Lysosome Acetylation Molecular motor Once they have formed, autophagosomes move bi-directionally along MTs and finally concentrate around the centrosome...

... ofα8β1 and interaction of α8β1 with LAP-TGFβ1 may influence cell behavior. * Author for correspondence (e-mail: [email protected] ) 3 9 2002 © The Company of Biologists Limited 2002 2002 Integrin LAP-TGF-β α8β1 Cell signaling TGF-β is a growth factor...