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Keywords: Cell shape
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Journal Articles
J Cell Sci jcs.258321.
Published: 11 June 2021
...Jean A. Castillo-Badillo; N. Gautam Cell shape regulation is important but the mechanisms that govern shape are not fully understood, in part due to limited experimental models where cell shape changes and underlying molecular processes can be rapidly and non-invasively monitored in real time. Here...
Journal Articles
J Cell Sci (2020) 133 (15): jcs242321.
Published: 12 August 2020
...Joshua Greig; Natalia A. Bulgakova ABSTRACT Precise regulation of cell shape is vital for building functional tissues. Here, we study the mechanisms that lead to the formation of highly elongated anisotropic epithelial cells in the Drosophila epidermis. We demonstrate that this cell shape is the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs242479.
Published: 03 July 2020
... order to execute a specific function, cells often acquire a particular shape. Here, we explore the mechanisms driving these morphological changes. Functional morphology Self-organization Emergence Cell shape Cell function Evolutionary fitness All objects obey the same physical laws...
Journal Articles
J Cell Sci (2018) 131 (14): jcs186254.
Published: 19 July 2018
...Priyamvada Chugh; Ewa K. Paluch ABSTRACT Precisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during development, as well as cancer progression. In animal cells, shape changes are primarily driven by...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (6): jcs214015.
Published: 26 March 2018
..., size or membrane curvature, may be probed by intracellular modules, such as the cytoskeleton, reaction–diffusion systems or molecular complexes. In multicellular tissues, cell shape emerges as an important means to transduce tissue-inherent chemical and mechanical cues into intracellular organization...
Journal Articles
J Cell Sci (2017) 130 (18): 3173–3185.
Published: 15 September 2017
... terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: A cell shape-based visual screen of S. pombe in the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4046–4056.
Published: 01 November 2016
..., distribution and reproduction in any medium provided that the original work is properly attributed. Summary: The Rho GTPase Rnd3 is known to alter cell shape and the actin cytoskeleton. Here, the semaphorin receptor plexin-B2 is identified as a new Rnd3 partner that mediates its effects on cell shape...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3375–3383.
Published: 15 September 2016
... and wound repair, cellular unjamming promotes cooperative cellular migration, whereas in cancer invasion, asthma and aberrant wound repair, it unleashes remarkably asocial cellular misbehavior. Cell jamming Cell unjamming Cell shape Collective cellular migration Epithelial cell Open...
Journal Articles
J Cell Sci (2012) 125 (13): 3061–3073.
Published: 01 July 2012
.... tension, compression or shear stress), alterations in extracellular matrix (ECM) mechanics and changes in cell shape, are transmitted to the nucleus directly or indirectly to orchestrate transcriptional activities that are crucial for embryogenesis and organogenesis. In this Commentary, we review how the...
Journal Articles
J Cell Sci (2011) 124 (24): 4267–4285.
Published: 15 December 2011
... cell shape and confluence; MTOC off-centering correlates with the polarization of single cells; acto-myosin contractility and microtubule dynamics are required for single-cell polarization; and end binding protein 1 and light intermediate chain 1, but not Par3 and light intermediate chain 2, are...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3356–3368.
Published: 01 October 2011
... POF1B to tight junctions has a key role in the organisation of epithelial monolayers by regulating the actin cytoskeleton. * Author for correspondence ( grazia.pietrini@unimi.it ) 27 5 2011 © 2011. 2011 Cell shape Epithelial polarity F-actin Primary cilia Tight junctions 3D...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 555–566.
Published: 15 February 2010
...Hiroyuki Nakajima; Takuji Tanoue Cell-shape change in epithelial structures is fundamental to animal morphogenesis. Recent studies identified myosin-II as the major generator of driving forces for cell-shape changes during morphogenesis. Lulu (Epb41l5) is a major regulator of morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 1939–1946.
Published: 15 June 2009
...Sam J. Mathew; Dirk Haubert; Martin Krönke; Maria Leptin Tumour necrosis factor α (TNFα) is a pro-inflammatory mediator with the capacity to induce apoptosis. An integral part of its apoptotic and inflammatory programmes is the control of cell shape through modulation of the cytoskeleton, but it...
Journal Articles
J Cell Sci (2009) 122 (9): 1362–1373.
Published: 01 May 2009
...Thomas J. Widmann; Christian Dahmann Morphogenesis is largely driven by changes in the shape of individual cells. However, how cell shape is regulated in developing animals is not well understood. Here, we show that the onset of TGFβ/Dpp signaling activity correlates with the transition from...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (23): 3890–3900.
Published: 01 December 2008
... (GCs) on a basal lamina. As oocytes start to grow the GCs change shape from flattened to cuboidal, increase their proliferation and form multiple layers, providing a unique model for studying the relationship between cell shape, proliferation and multilayering within the context of two different...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3649–3663.
Published: 01 November 2008
... 2008 © The Company of Biologists Limited 2008 2008 Epithelial cell polarity Cell shape Topology Surface surveillance Morphogenesis 3D cell culture Volume Force Organs are elaborate cell communities that perform specialized functions. The cell as their smallest unit plays an...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (16): 2625–2628.
Published: 15 August 2008
.... Author for correspondence (e-mail: msb@mrc-lmb.cam.ac.uk ) 25 6 2008 © The Company of Biologists Limited 2008 2008 Cell shape Integrin Cytoskeleton Membrane recycling Leading lamella Endocytosis Exocytosis Fibroblast Front-to-back model Observation of the shape of...
Journal Articles
J Cell Sci (2007) 120 (6): 1061–1071.
Published: 15 March 2007
... epithelial motility, cell-cell adhesion via cadherins controls the remodelling of epithelial sheets. We have used the Drosophila wing epithelium to demonstrate that cell-ECM interactions mediated by integrins also regulate the changes in cell shape that underly epithelial morphogenesis. We show that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (10): 1955–1960.
Published: 15 April 2004
... Microfilaments Y 27632 Morphometry Cell shape Micropatterned adhesiveness In experiments with linear strips of adhesive substrate, it has been found that elongated cultured fibroblasts preserve their length regardless of cell width and number of cytoplasmic processes. In contrast to fibroblasts...
Journal Articles
J Cell Sci (2003) 116 (24): 4925–4934.
Published: 15 December 2003
... Human papillomavirus E6 Discs large Cell shape Intercellular adhesion Epithelial-mesenchymal transition A small subset of human papillomavirus (HPV) types has been shown to be the causative agents of several epithelial-based cancers, the most common being carcinoma of the uterine cervix...