...Akash Chinchole; Kaisar Ahmad Lone; Shweta Tyagi ABSTRACT Attainment of proper cell shape and the regulation of cell migration are essential processes in the development of an organism. The mixed lineage leukemia (MLL or KMT2A) protein, a histone 3 lysine 4 (H3K4) methyltransferase, plays...

... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...

...Jean A. Castillo-Badillo; N. Gautam ABSTRACT Cell shape regulation is important, but the mechanisms that govern shape are not fully understood, in part due to limited experimental models in which cell shape changes and underlying molecular processes can be rapidly and non-invasively monitored...

...Joshua Greig; Natalia A. Bulgakova ABSTRACT Precise regulation of cell shape is vital for building functional tissues. Here, we study the mechanisms that lead to the formation of highly elongated anisotropic epithelial cells in the Drosophila epidermis. We demonstrate that this cell shape...

... between directional sensing and polarization . J. Biol. Chem.   278 , 20445 - 20448 . 10.1074/jbc.R300010200 Diz-Muñoz , A. , Fletcher , D. A. and Weiner , O. D. ( 2013 ). Use the force: membrane tension as an organizer of cell shape and motility . Trends Cell Biol.   23 , 47...

...Priyamvada Chugh; Ewa K. Paluch ABSTRACT Precisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during development, as well as cancer progression. In animal cells, shape changes are primarily driven...

..., size or membrane curvature, may be probed by intracellular modules, such as the cytoskeleton, reaction–diffusion systems or molecular complexes. In multicellular tissues, cell shape emerges as an important means to transduce tissue-inherent chemical and mechanical cues into intracellular organization...

... Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: A cell shape-based visual screen of S. pombe in the presence of actinomycete...

... and reproduction in any medium provided that the original work is properly attributed. Summary: The Rho GTPase Rnd3 is known to alter cell shape and the actin cytoskeleton. Here, the semaphorin receptor plexin-B2 is identified as a new Rnd3 partner that mediates its effects on cell shape. Plexin Rho...

... and wound repair, cellular unjamming promotes cooperative cellular migration, whereas in cancer invasion, asthma and aberrant wound repair, it unleashes remarkably asocial cellular misbehavior. Cell jamming Cell unjamming Cell shape Collective cellular migration Epithelial cell National...

.... tension, compression or shear stress), alterations in extracellular matrix (ECM) mechanics and changes in cell shape, are transmitted to the nucleus directly or indirectly to orchestrate transcriptional activities that are crucial for embryogenesis and organogenesis. In this Commentary, we review how...

... by cell shape and confluence; MTOC off-centering correlates with the polarization of single cells; acto-myosin contractility and microtubule dynamics are required for single-cell polarization; and end binding protein 1 and light intermediate chain 1, but not Par3 and light intermediate chain 2...

... that downregulation of claudin-2 might at least contribute to the lack of a TER peak in Mut cells, although the unaffected permeability properties of these cells might suggest that other claudins compensate for the claudin-2 defect. It is known that a regular cell shape (as defined by the polygonal nature...

...Hiroyuki Nakajima; Takuji Tanoue Cell-shape change in epithelial structures is fundamental to animal morphogenesis. Recent studies identified myosin-II as the major generator of driving forces for cell-shape changes during morphogenesis. Lulu (Epb41l5) is a major regulator of morphogenesis...

...Sam J. Mathew; Dirk Haubert; Martin Krönke; Maria Leptin Tumour necrosis factor α (TNFα) is a pro-inflammatory mediator with the capacity to induce apoptosis. An integral part of its apoptotic and inflammatory programmes is the control of cell shape through modulation of the cytoskeleton...

...Thomas J. Widmann; Christian Dahmann Morphogenesis is largely driven by changes in the shape of individual cells. However, how cell shape is regulated in developing animals is not well understood. Here, we show that the onset of TGFβ/Dpp signaling activity correlates with the transition from...

... (GCs) on a basal lamina. As oocytes start to grow the GCs change shape from flattened to cuboidal, increase their proliferation and form multiple layers, providing a unique model for studying the relationship between cell shape, proliferation and multilayering within the context of two different...

... and hydrostatic pressure or vice versa. Understanding lumen formation reflects our understanding of how cells polarize during organogenesis and how regulation of cellular mechanics coordinates cell shape changes. Different ways of lumen formation exist ( Lubarsky and Krasnow, 2003 ; Martin-Belmonte and Mostov...

.... Author for correspondence (e-mail: [email protected] ) 25 6 2008 © The Company of Biologists Limited 2008 2008 Cell shape Integrin Cytoskeleton Membrane recycling Leading lamella Endocytosis Exocytosis Fibroblast Front-to-back model Observation of the shape...

... epithelial motility, cell-cell adhesion via cadherins controls the remodelling of epithelial sheets. We have used the Drosophila wing epithelium to demonstrate that cell-ECM interactions mediated by integrins also regulate the changes in cell shape that underly epithelial morphogenesis. We show...