... will provide new insights into the long-term effects of radiation. 6 6 2012 © 2012. Published by The Company of Biologists Ltd 2012 * Author for correspondence ( [email protected] ) DNA double-strand break repair Unrepairable DSBs Ionising radiation Cell senescence γH2AX...

... as an early marker to identify senescent cells. Here, we applied quantitative image-processing tools to study the changes in nuclear architecture during cell senescence. We found that centromeres and telomeres colocalised with lamina intranuclear structures, which resulted in a preferred peripheral...

... by Company of Biologists 1990 human fibroblasts limited lifespan Hayflick limit mortalization growth-regulation cell senescence DNA synthesis The growth of normal human diploid fibroblasts is characterised by a finite and predictable lifespan (Hayflick and Moorehead, 1961; Shall, 1987...