...Jun-Kai Lai; Han-Chung Wu; Yuh-Chiang Shen; Hsin-Ying Hsieh; Shu-Yi Yang; Chia-Che Chang Summary Hepatocyte growth factor/scatter factor (HGF) is unique by inducing epithelial cell scattering, a cellular event pivotal to HGF-mediated invasive-growth response essential for embryonic development...

... to promote cell scattering upon serum deprivation. Once activated by ROS, PKCδ itself activates ROS production at least partially through NADPH oxidase. In addition, the c-Jun N-terminal kinase is identified as a crucial downstream mediator of ROS and PKCδ for induction of cell scattering upon serum...

...M. Grassi; G. Moens; P. Rousselle; J. P. Thiéry; J. Jouanneau ABSTRACT We have previously reported that an in vivo-selected metastatic variant of NBT-II rat carcinoma cells, M-NBT-II, produces and secretes a factor with cell-scattering activity, SFL, that is potentially involved in tumor...

... monoclonal antibody. Cell scattering was dependent on the extra-cellular concentration of Ca 2+ ; an increase from 1.6 to 10 mM in the concentration of this ion completely blocked the morphological effects of TPA as well as its action on cell aggregation. This high concentration of Ca 2+ also prevented...