... of the transcription factors OCT-4 (also known as POU5F1), SOX-2, KLF-4 and MYC, leading somatic cells to a pluripotent state. In this Review, we present an overview of the challenges of cell reprogramming protocols with regard to HSC generation from iPSCs, and highlight the potential role of miRNAs in cell...

... control over the timing and dosage of gene product expression allow straightforward studies of stemness and cell reprogramming pathways at the molecular level. Using protein transduction, we generated cell-permeant versions of the core pluripotency factors Oct4 and Sox2 proteins (Bosnali and Edenhofer...

.... Published by The Company of Biologists Ltd 2013 Cell reprogramming Pancreatic progenitor cells Directed differentiation Hepatic cells Type 1 diabetes The incidence of type 1 diabetes (T1D) is increasing dramatically. Islet beta cell replacement therapy is one of the most promising...