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Keywords: Cell polarity
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Journal Articles
J Cell Sci (2020) 133 (11): jcs240283.
Published: 11 June 2020
... Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site. Cell polarity Protein–protein interaction SPLIFF Positive feedback Split-ubiquitin Yeast Cdc42...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs231720.
Published: 02 September 2019
... uropod in polarized Ba/F3 cells ( Fig. 7 Ac,Bc). Therefore, LLSYKH residues are critical for ATP11C-b localization to the uropod. We next asked whether mislocalization of ATP11C-b affects cell polarity generation and maintenance. Although the polarized localization of ATP11C-b was abolished after...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (14): jcs230714.
Published: 15 July 2019
... signaling hubs to promote cell polarization and actin nucleation. Here, we probe the nature of these domains using a variety of membrane- and actin cortex-associated probes. These data demonstrate that these domains are filopodia, which are stimulated transiently during polarity establishment and accumulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs224501.
Published: 17 June 2019
...Indrasen Magre; Vikas Fandade; Indraneel Damle; Poulomi Banerjee; Santosh Kumar Yadav; Mahendra Sonawane; Jomon Joseph ABSTRACT The Par polarity complex, consisting of Par3, Par6 and atypical protein kinase C (aPKC), plays a crucial role in the establishment and maintenance of cell polarity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs230706.
Published: 31 May 2019
... chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (8): jcs225243.
Published: 15 April 2019
...://www.biologists.com/user-licence-1-1/ Summary: Troponin I, formerly thought to be a muscle-specific protein, contributes to apico-basal polarity in epithelial and neuroblast cells. Its depletion leads to apoptosis and DNA damage through separate mechanisms. Drosophila Cell polarity DNA damage PI3K...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs217554.
Published: 30 January 2019
...Kim J. A. Vendel; Sophie Tschirpke; Fayezeh Shamsi; Marileen Dogterom; Liedewij Laan ABSTRACT Cell polarity – the morphological and functional differentiation of cellular compartments in a directional manner – is required for processes such as orientation of cell division, directed cellular growth...
Includes: Supplementary data
Journal Articles
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Cilia and Flagella
J Cell Sci (2018) 131 (20): jcs221853.
Published: 17 October 2018
..., also known as STK10) or Ste20-like kinase (SLK). We also discuss how ezrin-binding scaffolding proteins regulate microvilli and how, despite these significant advances, it remains to be discovered how the cell polarity program ultimately interfaces with these processes. * Author for correspondence...
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (14): jcs216580.
Published: 19 July 2018
...Ye Dee Tay; Marcin Leda; Andrew B. Goryachev; Kenneth E. Sawin ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213199.
Published: 11 June 2018
... their apical cell surface delivery to promote accurate tubulocyst formation. Galectin-3 β1-integrin Apical transport Endocytosis Cell polarity Epithelial cells maintain a polarized structure in which the apical membrane domain is separated by a tight junctional complex from the...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (6): jcs214015.
Published: 26 March 2018
.... and Gönczy , P. ( 2017 ). TRACMIT: an effective pipeline for tracking and analyzing cells on micropatterns through mitosis . PLoS ONE   12 , e0179752 . 10.1371/journal.pone.0179752 Butler , M. T. and Wallingford , J. B. ( 2017 ). Planar cell polarity in development and...
Journal Articles
In collection:
Polarity
J Cell Sci (2017) 130 (7): 1224–1231.
Published: 01 April 2017
... of the daughter cells. Since most plasma membrane proteins are glycosylated, we determined the effect of attenuation of N-glycosylation on cell polarity. While polarity establishment was not perturbed, the size difference between the two cells formed in first cell division (AB and P1) was more...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 243–259.
Published: 01 January 2017
... 3D epithelial organization. Cell polarity Epithelial Cells Tight junctions Morphogenesis Lumen Formation The ability to form and expand lumens is an essential characteristic of epithelia within tubular organs, such as kidneys and intestines, and is indispensable to their function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (22): 4252–4264.
Published: 15 November 2016
... oskar mRNA in Drosophila oocytes. RNA localization Molecular motor Cell polarity Actin Asymmetric protein sorting underlies the establishment and maintenance of cell polarity. Recent studies have revealed that mRNA localization is a prevalent mechanism used by different cell types...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4130–4142.
Published: 01 November 2016
... cancer-promoting phosphatase PRL-3 triggers ectopic lumen formation through midbody mispositioning by accelerating cytokinesis, suggesting a new oncogenic mechanism. PRL-3 PTP4A3 Midbody Cell polarity Epithelia Cancer Defects in polarized epithelial tissue architecture are the source...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3462–3472.
Published: 15 September 2016
... reversed ( Movie 2 ). The chemotactic responses of eukaryotic cells can be conceptually divided into four stages: (1) induction of protrusions, (2) turning of these protrusions into the direction of the gradient, (3) competition between the protrusions and, (4) global redirection of cell polarity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1915–1927.
Published: 01 May 2016
... contractility. Epidermal progenitor monolayer formation and epidermal spreading are delayed in Crash mice, which possess a dominant mutation in Celsr1, an orthologue of the core planar cell polarity (PCP) Drosophila protein Flamingo (also known as Stan). We observe a failure of ventral enclosure in Crash...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2106–2117.
Published: 01 June 2015
... for correspondence ( park.294@osu.edu ) Competing interests The authors declare no competing or financial interests. 25 11 2014 30 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Cell polarity Budding pattern Computational modeling Saccharomyces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 1001–1010.
Published: 01 March 2015
... Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. KIF11 ZBP1 Cell polarity Cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 499–515.
Published: 01 February 2015
.... * These authors contributed equally to this work References Adler   P. N. ( 2012 ). Chapter one – the frizzled/stan pathway and planar cell polarity in the Drosophila wing.   In   Current Topics in Developmental Biology   Yang   Y , ed 1 – 31 . San Diego, CA : Academic Press...
Includes: Supplementary data