...Shengnan Zheng; Biyu Zheng; Zhenbang Liu; Xiaopeng Ma; Xing Liu; Xuebiao Yao; Wenfan Wei; Chuanhai Fu ABSTRACT Septins are a family of filament-forming GTP-binding proteins that regulate fundamental cellular activities, such as cytokinesis and cell polarity. In general, septin filaments function...

...://www.biologists.com/user-licence-1-1/ Summary: The Cdc42 guanine-nucleotide-exchange factor Cdc24 interacts with septins during bud site assembly. This interaction assists in recruiting septins and stabilizing Cdc24 at the incipient bud site. Cell polarity Protein–protein interaction SPLIFF Positive...

... http://www.biologists.com/user-licence-1-1/ Summary: ATP11C-b, a C-terminal splice variant of the PS-flippase ATP11C, localizes to a limited region of the plasma membrane in polarized cells, and LLXY residues are critical for the localization. Cell polarity Membrane lipids Transporters...

... signaling hubs to promote cell polarization and actin nucleation. Here, we probe the nature of these domains using a variety of membrane- and actin cortex-associated probes. These data demonstrate that these domains are filopodia, which are stimulated transiently during polarity establishment and accumulate...

...Indrasen Magre; Vikas Fandade; Indraneel Damle; Poulomi Banerjee; Santosh Kumar Yadav; Mahendra Sonawane; Jomon Joseph ABSTRACT The Par polarity complex, consisting of Par3, Par6 and atypical protein kinase C (aPKC), plays a crucial role in the establishment and maintenance of cell polarity...

... on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...

..., Industria y Competitividad grants BFU2012-38191 and BFU2015-65685-P. References Ahringer , J. ( 2003 ). Control of cell polarity and mitotic spindle positioning in animal cells . Curr. Opin. Cell Biol.   15 , 73 - 81 . 10.1016/S0955-0674(02)00018-2 Asnacios , A. and Hamant...

...Kim J. A. Vendel; Sophie Tschirpke; Fayezeh Shamsi; Marileen Dogterom; Liedewij Laan ABSTRACT Cell polarity – the morphological and functional differentiation of cellular compartments in a directional manner – is required for processes such as orientation of cell division, directed cellular growth...

..., also known as STK10) or Ste20-like kinase (SLK). We also discuss how ezrin-binding scaffolding proteins regulate microvilli and how, despite these significant advances, it remains to be discovered how the cell polarity program ultimately interfaces with these processes. References Anniko , M...

...Ye Dee Tay; Marcin Leda; Andrew B. Goryachev; Kenneth E. Sawin ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little...

... their apical cell surface delivery to promote accurate tubulocyst formation. Galectin-3 β1-integrin Apical transport Endocytosis Cell polarity Epithelial cells maintain a polarized structure in which the apical membrane domain is separated by a tight junctional complex from the basolateral...

... ). TRACMIT: an effective pipeline for tracking and analyzing cells on micropatterns through mitosis . PLoS ONE   12 , e0179752 . 10.1371/journal.pone.0179752 Butler , M. T. and Wallingford , J. B. ( 2017 ). Planar cell polarity in development and disease . Nat. Rev. Mol. Cell Biol.   18...

... of the daughter cells. Since most plasma membrane proteins are glycosylated, we determined the effect of attenuation of N-glycosylation on cell polarity. While polarity establishment was not perturbed, the size difference between the two cells formed in first cell division (AB and P1) was more variable in embryos...

.... Cell polarity Epithelial Cells Tight junctions Morphogenesis Lumen Formation The ability to form and expand lumens is an essential characteristic of epithelia within tubular organs, such as kidneys and intestines, and is indispensable to their function. Such lumens are lined by a monolayer...

... Molecular motor Cell polarity Actin Asymmetric protein sorting underlies the establishment and maintenance of cell polarity. Recent studies have revealed that mRNA localization is a prevalent mechanism used by different cell types for restricting protein localization ( Cajigas et al., 2012...

... cultures ( Al-Aidaroos and Zeng, 2010 ; Rios et al., 2013 ). PRL-3 PTP4A3 Midbody Cell polarity Epithelia Cancer Summary: The cancer-promoting phosphatase PRL-3 triggers ectopic lumen formation through midbody mispositioning by accelerating cytokinesis, suggesting a new oncogenic...

... , A. and Ecke , M. ( 2012 ). PIP3 waves and PTEN dynamics in the emergence of cell polarity . Biophys. J.   103 , 1170 - 1178 . 10.1016/j.bpj.2012.08.004 Gerisch , G. , Ecke , M. , Neujahr , R. , Prassler , J. , Stengl , A. , Hoffmann , M. , Schwarz , U. S...

... progenitor monolayer formation and epidermal spreading are delayed in Crash mice, which possess a dominant mutation in Celsr1, an orthologue of the core planar cell polarity (PCP) Drosophila protein Flamingo (also known as Stan). We observe a failure of ventral enclosure in Crash mutants suggesting...

.... Cell polarity Budding pattern Computational modeling Saccharomyces cerevisiae GTPase Cell polarization generally occurs along a single axis in response to spatial cues. In the budding yeast Saccharomyces cerevisiae , the axis of polarized growth is determined by selection of a bud site...

...   R. H. ( 2007 ). ZBP1 enhances cell polarity and reduces chemotaxis.   J. Cell Sci.   120 , 3173 – 3178 . 10.1242/jcs.000638 Latham   V. M. , Yu   E. H. , Tullio   A. N. , Adelstein   R. S. , Singer   R. H. ( 2001 ). A Rho-dependent signaling pathway operating through...