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1-20 of 110
Keywords: Cell motility
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2025) 138 (2): jcs263541.
Published: 24 January 2025
...Itziar Pinilla-Macua; Sachin Surve; Alexander Sorkin ABSTRACT Ligand binding to EGFR activates Rho family GTPases, triggering actin cytoskeleton reorganization, cell migration and invasion. Activated EGFR is also rapidly endocytosed but the role of EGFR endocytosis in cell motility is poorly...
Includes: Supplementary data
Journal Articles
CK1α protects WAVE from degradation to regulate cell shape and motility in the immune response
Open Access
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...
Includes: Supplementary data
Journal Articles
In collection:
Cell migration
Zhenguo Yang, Shuilong Wu, Federica Fontana, Yanyu Li, Wei Xiao, Zhangdai Gao, Alice Krudewig, Markus Affolter, Heinz-Georg Belting, Salim Abdelilah-Seyfried, Jingjing Zhang
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (1): jcs248237.
Published: 11 January 2021
... of claudin-5 results in increased motility of dorsal aorta endothelial cells and in a failure of the dorsal aorta to lumenize. Our findings uncover a novel role of claudin-5 in limiting arterial endothelial cell motility, which goes beyond its traditional sealing function during embryonic development...
Journal Articles
In collection:
Cilia and flagella
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (20): jcs246637.
Published: 22 October 2020
... with defects in inner and outer dynein arms indicate differences in dynein arm function . Cell Motil. Cytoskeleton 8 , 68 - 75 . 10.1002/cm.970080110 Bui , K. H. , Sakakibara , H. , Movassagh , T. , Oiwa , K. and Ishikawa , T. ( 2009 ). Asymmetry of inner dynein arms...
Includes: Supplementary data
Journal Articles
Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration
Available to PurchaseYi Liu, Jaeyoun Kim, Reuben Philip, Vaishali Sridhar, Megha Chandrashekhar, Jason Moffat, Mark van Breugel, Laurence Pelletier
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (8): jcs238352.
Published: 23 April 2020
... is necessary for robust PLK4 activation and centriole duplication. Here, we show that CEP85 and STIL are also required for directional cancer cell migration. Mutational and functional analyses reveal that the interactions between CEP85, STIL and PLK4 are essential for effective directional cell motility...
Includes: Supplementary data
Journal Articles
Catherine A. Moreau, Katharina A. Quadt, Henni Piirainen, Hirdesh Kumar, Saligram P. Bhargav, Léanne Strauss, Niraj H. Tolia, Rebecca C. Wade, Joachim P. Spatz, Inari Kursula, Friedrich Frischknecht
Journal:
Journal of Cell Science
J Cell Sci (2021) 134 (5): jcs233775.
Published: 15 April 2020
... ). Actin filament formation and turnover are key to many cellular processes, including cell motility, and are hence regulated by many different actin-binding proteins. Profilin is a key actin-binding protein in most eukaryotic cells. Mammalian profilins are an important factor regulating actin...
Includes: Supplementary data
Journal Articles
In collection:
Stem cell biology and organoids
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (2): jcs232470.
Published: 23 January 2020
... to develop a matrix-remodeling phenotype, which promoted increased cancer cell proliferation and invasion. Breast cancer Tumor microenvironment Cancer cell invasion ECM remodeling Mesenchymal stem cells Senescence Cell motility National Science Foundation 10.13039/100000001 1825174...
Includes: Supplementary data
Journal Articles
α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (5): jcs207019.
Published: 6 March 2018
.../100009633 U54HD083211 Ruth L. Kirschstein National Research Service Award CA189710 National Institutes of Health 10.13039/100000002 GM092914 S10RR025524 R01GM117916 Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase...
Includes: Supplementary data
Journal Articles
Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation
Available to PurchaseIn collection:
Cell migration
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (14): 2329–2343.
Published: 15 July 2017
... with an unexpected enhancement in the migration of single β-PIX knockdown cells and monolayers of such cells. We propose that targeting β-PIX might be a means of promoting epithelialization of wounds in vivo . Cell motility Collective cell migration Adhesion Cytoskeleton Traction force National...
Includes: Supplementary data
Journal Articles
Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration
Available to PurchaseIn collection:
Adhesion
Srikanth R. Polusani, Edward A. Kalmykov, Anjana Chandrasekhar, Shoshanna N. Zucker, Bruce J. Nicholson
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 1 December 2016
...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...
Includes: Supplementary data
Journal Articles
Multifunctional Abl kinases in health and disease
Available to PurchaseIn collection:
Cell biology and disease
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (1): 9–16.
Published: 1 January 2016
... of the ETV6 gene to either ABL1 or ABL2 (reviewed in De Braekeleer et al., 2012 ). Abelson kinases Cytoskeletal reorganization Cell motility Polarity Adhesion Endocytosis Microbial pathogens Cancer Inflammation Summary: We highlight the emerging roles of Abl kinases...
Includes: Supplementary data
Journal Articles
Hsp90α and Hsp90β together operate a hypoxia and nutrient paucity stress‐response mechanism during wound healing
Available to PurchasePriyamvada Jayaprakash, Hangming Dong, Mengchen Zou, Ayesha Bhatia, Kathryn O'Brien, Mei Chen, David T. Woodley, Wei Li
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (8): 1475–1480.
Published: 15 April 2015
... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...
Journal Articles
Specific interaction of KIF11 with ZBP1 regulates the transport of β-actin mRNA and cell motility
Open AccessTingting Song, Yi Zheng, Yarong Wang, Zachary Katz, Xin Liu, Shaoying Chen, Robert H. Singer, Wei Gu
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (5): 1001–1010.
Published: 1 March 2015
.... for their technical assistance. We also thank Alice Xue in Pelham Memorial High School for cell motility analysis. Author contributions T.S. and Y.Z. designed and carried out major biochemical experiments. Z.K. and Y.W. designed, carried out and interpreted live-cell imaging and cell motility experiments...
Includes: Supplementary data
Journal Articles
Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility
Available to PurchaseIn collection:
Imaging
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (16): 3546–3554.
Published: 15 August 2014
...) CXCR5 neddylation stimulates cell migration and motility. Our work has uncovered a pathway involving FANCA in neddylation and cell motility. * Present address: INSERM U1068, Centre de Recherche en Cancérologie, 13009 Marseille, France. ‡ Author for correspondence ( filippo.rosselli...
Includes: Supplementary data
Journal Articles
A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling
Available to PurchaseAngela Barrett, Ian M. Evans, Antonina Frolov, Gary Britton, Caroline Pellet-Many, Maiko Yamaji, Vedanta Mehta, Rina Bandopadhyay, Ningning Li, Sebastian Brandner, Ian C. Zachary, Paul Frankel
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (12): 2647–2658.
Published: 15 June 2014
...Angela Barrett; Ian M. Evans; Antonina Frolov; Gary Britton; Caroline Pellet-Many; Maiko Yamaji; Vedanta Mehta; Rina Bandopadhyay; Ningning Li; Sebastian Brandner; Ian C. Zachary; Paul Frankel ABSTRACT DOK1 regulates platelet-derived growth factor (PDGF)-BB-stimulated glioma cell motility...
Includes: Supplementary data
Journal Articles
Rosario Espejo, Yowjiun Jeng, Adriana Paulucci-Holthauzen, William Rengifo-Cam, Krysta Honkus, Panos Z. Anastasiadis, Sarita K. Sastry
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (3): 497–508.
Published: 1 February 2014
... with the guanine nucleotide exchange factor, VAV2, and cortactin. Exchange factor activity of VAV2 is enhanced by PTP-PEST knockdown whereas overexpression of a VAV2 C-terminal domain or DH domain mutant blocks cell motility. Analysis of point mutations identified tyrosine 335 in the N-terminal domain of p120...
Journal Articles
The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α–aPKCζ that are affected by Lgl1 phosphorylation
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (2): 295–304.
Published: 15 January 2014
... ). * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 16 01 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Cell motility Lethal giant larvae (Lgl) Non-muscle myosin Cell...
Includes: Supplementary data
Journal Articles
A dual role for Rac1 GTPases in the regulation of cell motility
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (2): 387–398.
Published: 15 January 2012
... cortex upon stimulation with chemoattractants. Moreover, cortical localization of the PAK1 GBD depends on the integrity of the actin cytoskeleton, whereas cortical localization of DGAP1 does not. Taken together, these results imply that Rac1 GTPases play a dual role in regulation of cell motility...
Includes: Multimedia, Supplementary data
Journal Articles
Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (18): 3041–3051.
Published: 15 September 2011
... and phagocytosis will, potentially, not only advance our grasp of the mechanisms underlying immune-cell motility but also open new lines of research that will promote a deeper understanding of the innate recognition of pathogens. * Author for correspondence ( [email protected] ) © 2011. 2011...
Includes: Multimedia, Supplementary data
Journal Articles
Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of β1 integrin
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (14): 2478–2487.
Published: 15 July 2011
... Cell motility Keratinocyte The processes of maintaining and repairing the skin throughout the lifetime of a mammalian organism are of fundamental importance ( Blanpain and Fuchs, 2009 ; Fuchs and Raghavan, 2002 ). In the skin, a layer of squamous stratified epithelium (the epidermis...
Includes: Multimedia, Supplementary data
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