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Keywords: Cell motility
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Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...
Includes: Supplementary data
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Cell Migration
J Cell Sci (2021) 134 (1): jcs248237.
Published: 11 January 2021
... of claudin-5 results in increased motility of dorsal aorta endothelial cells and in a failure of the dorsal aorta to lumenize. Our findings uncover a novel role of claudin-5 in limiting arterial endothelial cell motility, which goes beyond its traditional sealing function during embryonic development...
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Cilia and Flagella
J Cell Sci (2020) 133 (20): jcs246637.
Published: 22 October 2020
... , e1007828 . 10.1371/journal.ppat.1007828 Brokaw , C. J. and Kamiya , R. ( 1987 ). Bending patterns of Chlamydomonas flagella: IV. Mutants with defects in inner and outer dynein arms indicate differences in dynein arm function . Cell Motil. Cytoskeleton   8 , 68 - 75 . 10.1002/cm...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238352.
Published: 23 April 2020
... is necessary for robust PLK4 activation and centriole duplication. Here, we show that CEP85 and STIL are also required for directional cancer cell migration. Mutational and functional analyses reveal that the interactions between CEP85, STIL and PLK4 are essential for effective directional cell motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs233775.
Published: 15 April 2020
... motility Actin filament formation and turnover are key to many cellular processes, including cell motility, and are hence regulated by many different actin-binding proteins. Profilin is a key actin-binding protein in most eukaryotic cells. Mammalian profilins are an important factor regulating...
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Stem Cells
J Cell Sci (2020) 133 (2): jcs232470.
Published: 23 January 2020
... in adhesion dependent processes and membrane dynamics were downregulated. Altogether, these results further support the idea that senescence results in a less-dynamic cytoskeletal structure that is not capable of cell polarization to drive cell motility. Fig. 1. Senescent MSCs displayed altered...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (5): jcs207019.
Published: 6 March 2018
... activity through the GTPase Rab5. Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase The establishment of cell polarity requires vesicular trafficking of proteins to distinct cellular locations, which is crucial for cell migration...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2017) 130 (14): 2329–2343.
Published: 15 July 2017
... cells and promotes collective cell migration during wound repair by promoting actomyosin fiber contraction. Cell motility Collective cell migration Adhesion Cytoskeleton Traction force During development and wound healing of epithelial tissues, cell–matrix adhesions...
Includes: Supplementary data
Journal Articles
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Adhesion
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 1 December 2016
...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 9–16.
Published: 1 January 2016
.../ncb949 Poppe , M. , Feller , S. M. , Römer , G. and Wessler , S. ( 2007 ). Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility . Oncogene   26 , 3462 - 3472 . 10.1038/sj.onc.1210139 Raimondi , C. ( 2014 ). Neuropilin-1 enforces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1475–1480.
Published: 15 April 2015
... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...
Journal Articles
J Cell Sci (2015) 128 (5): 1001–1010.
Published: 1 March 2015
... and localize ZBP1–β-actin mRNA cargoes. Cells were cultured in wells of a glass-bottomed 24-well plate (MatTek) in DMEM medium containing 10% FBS. Before imaging, the medium was changed to L-15 (Gibco) containing 10% FBS. Cell motility imaging was performed on an IX71 inverted Olympus microscope at 20...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3546–3554.
Published: 15 August 2014
...) CXCR5 neddylation stimulates cell migration and motility. Our work has uncovered a pathway involving FANCA in neddylation and cell motility. * Present address: INSERM U1068, Centre de Recherche en Cancérologie, 13009 Marseille, France. ‡ Author for correspondence ( filippo.rosselli...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (12): 2647–2658.
Published: 15 June 2014
...Angela Barrett; Ian M. Evans; Antonina Frolov; Gary Britton; Caroline Pellet-Many; Maiko Yamaji; Vedanta Mehta; Rina Bandopadhyay; Ningning Li; Sebastian Brandner; Ian C. Zachary; Paul Frankel ABSTRACT DOK1 regulates platelet-derived growth factor (PDGF)-BB-stimulated glioma cell motility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 497–508.
Published: 1 February 2014
... with the guanine nucleotide exchange factor, VAV2, and cortactin. Exchange factor activity of VAV2 is enhanced by PTP-PEST knockdown whereas overexpression of a VAV2 C-terminal domain or DH domain mutant blocks cell motility. Analysis of point mutations identified tyrosine 335 in the N-terminal domain of p120...
Journal Articles
J Cell Sci (2014) 127 (2): 295–304.
Published: 15 January 2014
.... * Author for correspondence ( shoshr@ekmd.huji.ac.il ) Competing interests The authors declare no competing interests. 16 01 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Cell motility Lethal giant larvae (Lgl) Non-muscle myosin Cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 387–398.
Published: 15 January 2012
... cortex upon stimulation with chemoattractants. Moreover, cortical localization of the PAK1 GBD depends on the integrity of the actin cytoskeleton, whereas cortical localization of DGAP1 does not. Taken together, these results imply that Rac1 GTPases play a dual role in regulation of cell motility...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3041–3051.
Published: 15 September 2011
... and phagocytosis will, potentially, not only advance our grasp of the mechanisms underlying immune-cell motility but also open new lines of research that will promote a deeper understanding of the innate recognition of pathogens. * Author for correspondence ( vheinrich@ucdavis.edu ) © 2011. 2011...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (14): 2478–2487.
Published: 15 July 2011
... . Kaverina I. , Krylyshkina O. , Small J. V. ( 2002 ). Regulation of substrate adhesion dynamics during cell motility . Int. J. Biochem. Cell Biol. 34 , 746 - 761 . Kirfel G. , Herzog V. ( 2004 ). Migration of epidermal keratinocytes: mechanisms, regulation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2120–2131.
Published: 1 July 2011
...@mit.edu ; john.condeelis@einstein.yu.edu ) 18 2 2011 © 2011. 2011 Breast cancer Cell motility Intravital imaging Metastasis Transendothelial migration Cell motility is essential for many aspects of metastasis; however, few molecular markers exist that can predict...
Includes: Multimedia, Supplementary data