...Itziar Pinilla-Macua; Sachin Surve; Alexander Sorkin ABSTRACT Ligand binding to EGFR activates Rho family GTPases, triggering actin cytoskeleton reorganization, cell migration and invasion. Activated EGFR is also rapidly endocytosed but the role of EGFR endocytosis in cell motility is poorly...

... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...

... of claudin-5 results in increased motility of dorsal aorta endothelial cells and in a failure of the dorsal aorta to lumenize. Our findings uncover a novel role of claudin-5 in limiting arterial endothelial cell motility, which goes beyond its traditional sealing function during embryonic development...

... with defects in inner and outer dynein arms indicate differences in dynein arm function . Cell Motil. Cytoskeleton   8 , 68 - 75 . 10.1002/cm.970080110 Bui , K. H. , Sakakibara , H. , Movassagh , T. , Oiwa , K. and Ishikawa , T. ( 2009 ). Asymmetry of inner dynein arms...

... is necessary for robust PLK4 activation and centriole duplication. Here, we show that CEP85 and STIL are also required for directional cancer cell migration. Mutational and functional analyses reveal that the interactions between CEP85, STIL and PLK4 are essential for effective directional cell motility...

... ). Actin filament formation and turnover are key to many cellular processes, including cell motility, and are hence regulated by many different actin-binding proteins. Profilin is a key actin-binding protein in most eukaryotic cells. Mammalian profilins are an important factor regulating actin...

... to develop a matrix-remodeling phenotype, which promoted increased cancer cell proliferation and invasion. Breast cancer Tumor microenvironment Cancer cell invasion ECM remodeling Mesenchymal stem cells Senescence Cell motility National Science Foundation 10.13039/100000001 1825174...

.../100009633 U54HD083211 Ruth L. Kirschstein National Research Service Award CA189710 National Institutes of Health 10.13039/100000002 GM092914 S10RR025524 R01GM117916 Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase...

... with an unexpected enhancement in the migration of single β-PIX knockdown cells and monolayers of such cells. We propose that targeting β-PIX might be a means of promoting epithelialization of wounds in vivo . Cell motility Collective cell migration Adhesion Cytoskeleton Traction force National...

...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...

... of the ETV6 gene to either ABL1 or ABL2 (reviewed in De Braekeleer et al., 2012 ). Abelson kinases Cytoskeletal reorganization Cell motility Polarity Adhesion Endocytosis Microbial pathogens Cancer Inflammation Summary: We highlight the emerging roles of Abl kinases...

... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...

.... for their technical assistance. We also thank Alice Xue in Pelham Memorial High School for cell motility analysis. Author contributions T.S. and Y.Z. designed and carried out major biochemical experiments. Z.K. and Y.W. designed, carried out and interpreted live-cell imaging and cell motility experiments...

...) CXCR5 neddylation stimulates cell migration and motility. Our work has uncovered a pathway involving FANCA in neddylation and cell motility. * Present address: INSERM U1068, Centre de Recherche en Cancérologie, 13009 Marseille, France. ‡ Author for correspondence ( filippo.rosselli...

...Angela Barrett; Ian M. Evans; Antonina Frolov; Gary Britton; Caroline Pellet-Many; Maiko Yamaji; Vedanta Mehta; Rina Bandopadhyay; Ningning Li; Sebastian Brandner; Ian C. Zachary; Paul Frankel ABSTRACT DOK1 regulates platelet-derived growth factor (PDGF)-BB-stimulated glioma cell motility...

... with the guanine nucleotide exchange factor, VAV2, and cortactin. Exchange factor activity of VAV2 is enhanced by PTP-PEST knockdown whereas overexpression of a VAV2 C-terminal domain or DH domain mutant blocks cell motility. Analysis of point mutations identified tyrosine 335 in the N-terminal domain of p120...

... ). * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing interests. 16 01 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Cell motility Lethal giant larvae (Lgl) Non-muscle myosin Cell...

... cortex upon stimulation with chemoattractants. Moreover, cortical localization of the PAK1 GBD depends on the integrity of the actin cytoskeleton, whereas cortical localization of DGAP1 does not. Taken together, these results imply that Rac1 GTPases play a dual role in regulation of cell motility...

... and phagocytosis will, potentially, not only advance our grasp of the mechanisms underlying immune-cell motility but also open new lines of research that will promote a deeper understanding of the innate recognition of pathogens. * Author for correspondence ( [email protected] ) © 2011. 2011...

... Cell motility Keratinocyte The processes of maintaining and repairing the skin throughout the lifetime of a mammalian organism are of fundamental importance ( Blanpain and Fuchs, 2009 ; Fuchs and Raghavan, 2002 ). In the skin, a layer of squamous stratified epithelium (the epidermis...