... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...

... of claudin-5 results in increased motility of dorsal aorta endothelial cells and in a failure of the dorsal aorta to lumenize. Our findings uncover a novel role of claudin-5 in limiting arterial endothelial cell motility, which goes beyond its traditional sealing function during embryonic development...

...: By using high speed, high-resolution fluorescence microscopy of swimming Leishmania cells, we showed that the asymmetric flagellar beat always wafts in the same direction and investigate which structures are involved. Leishmania Flagellum Cilium Cell motility Asymmetry Trypanosomatid...

... is necessary for robust PLK4 activation and centriole duplication. Here, we show that CEP85 and STIL are also required for directional cancer cell migration. Mutational and functional analyses reveal that the interactions between CEP85, STIL and PLK4 are essential for effective directional cell motility...

... that a divergent motif of profilin has a role in Plasmodium sporozoite migration, which is important for malaria transmission. Optical tweezers Gliding motility Malaria Plasmodium Sporozoite Profilin Cell motility Plasmodium profilin is a key regulator of actin dynamics and is likely...

... Tumor microenvironment Cancer cell invasion ECM remodeling Mesenchymal stem cells Senescence Cell motility National Science Foundation 10.13039/100000001 1825174 HL134625 National Institutes of Health 10.13039/100000002 P30 GM110750 Mesenchymal stem cells (MSCs...

... APPL1 regulates α5β1 integrin and Rac activity through the GTPase Rab5. Integrin trafficking Cell motility Extracellular matrix 3D migration Endosomes p21-activated kinase National Institutes of Health 10.13039/100000002 GM092914 S10RR025524 R01GM117916 Ruth L...

... cells and promotes collective cell migration during wound repair by promoting actomyosin fiber contraction. Cell motility Collective cell migration Adhesion Cytoskeleton Traction force National Institute of Arthritis and Musculoskeletal and Skin Diseases 10.13039/100000069 R01...

...Srikanth R. Polusani; Edward A. Kalmykov; Anjana Chandrasekhar; Shoshanna N. Zucker; Bruce J. Nicholson ABSTRACT Gap junction proteins (connexins) have crucial effects on cell motility in many systems, from migration of neural crest cells to promotion of metastatic invasiveness. Here, we show...

... of Biologists Ltd 2016 Summary: We highlight the emerging roles of Abl kinases in the regulation of cellular processes in normal cells and diverse pathologies that range from cancer to microbial pathogenesis. Abelson kinases Cytoskeletal reorganization Cell motility Polarity Adhesion...

... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...

... a direct interaction with ZBP1, regulates the transport of β-actin mRNP and leads to cell motility. In mobile cells, ZBP1 binds to β-actin mRNA and mediates its localized translation. In order to identify potential motor proteins that directly associate with ZBP1 and contribute to the transport...

...) CXCR5 neddylation stimulates cell migration and motility. Our work has uncovered a pathway involving FANCA in neddylation and cell motility. * Present address: INSERM U1068, Centre de Recherche en Cancérologie, 13009 Marseille, France. ‡ Author for correspondence ( filippo.rosselli...

...Angela Barrett; Ian M. Evans; Antonina Frolov; Gary Britton; Caroline Pellet-Many; Maiko Yamaji; Vedanta Mehta; Rina Bandopadhyay; Ningning Li; Sebastian Brandner; Ian C. Zachary; Paul Frankel ABSTRACT DOK1 regulates platelet-derived growth factor (PDGF)-BB-stimulated glioma cell motility...

... with the guanine nucleotide exchange factor, VAV2, and cortactin. Exchange factor activity of VAV2 is enhanced by PTP-PEST knockdown whereas overexpression of a VAV2 C-terminal domain or DH domain mutant blocks cell motility. Analysis of point mutations identified tyrosine 335 in the N-terminal domain of p120...

.... Published by The Company of Biologists Ltd 2014 Cell motility Lethal giant larvae (Lgl) Non-muscle myosin Cell migration is a highly integrated multistep process involving coordinated cytoskeletal remodeling ( Lauffenburger and Horwitz, 1996 ; Mitchison and Cramer, 1996 ). The basic steps...

... cortex upon stimulation with chemoattractants. Moreover, cortical localization of the PAK1 GBD depends on the integrity of the actin cytoskeleton, whereas cortical localization of DGAP1 does not. Taken together, these results imply that Rac1 GTPases play a dual role in regulation of cell motility...

... and phagocytosis will, potentially, not only advance our grasp of the mechanisms underlying immune-cell motility but also open new lines of research that will promote a deeper understanding of the innate recognition of pathogens. References Afonso P. V. , Parent C. A. 2011 . PI3K and chemotaxis...

... Cell motility Keratinocyte The processes of maintaining and repairing the skin throughout the lifetime of a mammalian organism are of fundamental importance ( Blanpain and Fuchs, 2009 ; Fuchs and Raghavan, 2002 ). In the skin, a layer of squamous stratified epithelium (the epidermis...

... - 239 . Giampieri S. , Manning C. , Hooper S. , Jones L. , Hill C. S. , Sahai E. ( 2009 ). Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility . Nat. Cell Biol. 11 , 1287 - 1296 . Goswami S...