... ‘Cell PLasticity Analysis Tool’ (cellPLATO), a Python-based analysis software designed for measurement and classification of cell behaviours based on clustering features of cell morphology and motility. Used after segmentation and tracking, the tool extracts features from each cell per timepoint, using...

...-activated kinases (PAKs), which are known downstream targets for RhoU, and induces cell morphological changes consistent with inhibiting RhoU function. Our results show for the first time that the activity of a Rho family member is stimulated by self-association, and this is important for its activity...

... change to the cells) when the number of ligands in the cluster was increased and that differences in the clustering of the ligands produced differences in cell morphology and migration even when the global ligand density remained unchanged. Micro- and nanopatterned surfaces have also been used to alter...

...Qing Zhou; Binghai Liu; Ying Sun; Cynthia Y. He Trypanosoma brucei, a flagellated protozoan parasite causing human sleeping sickness, relies on a subpellicular microtubule array for maintenance of cell morphology. The flagellum is attached to the cell body through a poorly understood flagellum...

..., and that this effect is mediated by N-cadherin. * Author for correspondence (e-mail: [email protected] ) 9 9 2008 © The Company of Biologists Limited 2008 2008 Adhesion Signal transduction Cell morphology Receptor tyrosine kinases of the EGF receptor (EGFR) family are implicated...

... islands caused altered cell morphology and actually increased the velocity of cell locomotion. Stable expression of either mutant protein also did not decrease cell migration velocity, but instead affected the directionality of migration in monolayer wound healing assays. We have also tested the effects...

... –/– macrophages are impaired in their ability to invade through Matrigel. Together, these data show that Rac1 and Rac2 have distinct roles in regulating cell morphology, migration and invasion, but are not essential for macrophage migration or chemotaxis. ‡ Author for correspondence (e-mail: a.ridley...

... mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology. For C57BL/6 mice, cells replated in 24-well plates were cultured overnight in growth medium containing bFGF and B27. The next day, each construct was transfected using Lipofectamine 2000 (Invitrogen...

... of the cytoplasmic pool of p120ctn from tumor cells suggests an important function for such isoforms in normal cells and tissues. * Author for correspondence (e-mail: [email protected] ) 8 1 2002 © The Company of Biologists Limited 2002 2002 Catenin Cadherin Cell-cell adhesion Cell...

.... * Author for correspondence (e-mail: [email protected] ) 03 04 1999 26 05 1999 © 1999 by Company of Biologists 1999 MT nucleation Tubulin monomer Cell morphology MTOC Microtubule polymerization Autoregulation In cells, the tubulin pool is partitioned...

... for correspondence 11 02 1999 08 04 1999 © 1999 by Company of Biologists 1999 Thyroid TGF-β Thrombospondin Cell morphology In vivo, thyroid follicles, the functional unit of the thyroid gland, are surrounded by mesenchymal tissue containing endothelial cells and fibroblasts...

... as the gene disruption showed the same phenotypes as those of the original mutants. Overexpression of the sts5 + gene resulted in altered cell morphology and, cortical actin in these overproducing cells was also abnormal, fainter and often dispersed. Anti-Sts5 antibody specifically detected a 130 kDa protein...