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Keywords: Cell migration
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Journal Articles
J Cell Sci (2021) 134 (8): jcs258574.
Published: 22 April 2021
... background. Actin stress Cell migration Leukocytes Live imaging Rac2 Over the past decade, zebrafish ( Danio rerio ) has gained popularity as a vertebrate model organism for biological and biomedical studies, including neutrophil biology ( Deng and Huttenlocher, 2012 ). Transparent embryos...
Includes: Supplementary data
Journal Articles
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Adhesion
J Cell Sci (2021) 134 (6): jcs254359.
Published: 29 March 2021
...Zofia Ostrowska-Podhorodecka; Isabel Ding; Wilson Lee; Jelena Tanic; Sevil Abbasi; Pamma D. Arora; Richard S. Liu; Alison E. Patteson; Paul A. Janmey; Christopher A. McCulloch ABSTRACT Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin...
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Mechanobiology
J Cell Sci (2021) 134 (6): jcs240226.
Published: 22 March 2021
..., and the mechanobiological responses of pericytes to these forces. Pericyte Cytoskeleton Contractility Cell migration Cell mechanics In vitro models Pericytes are mural cells of the microvasculature that are embedded in the vessel basement membrane (BM), where they surround...
Journal Articles
J Cell Sci (2021) 134 (1): jcs244616.
Published: 13 January 2021
...Jie Liu; Zhongzhen Liu; Keng Chen; Wei Chen; Xiyuan Fang; Meng Li; Xuening Zhou; Ning Ding; Huan Lei; Chen Guo; Tao Qian; Yilin Wang; Lin Liu; Yonglong Chen; Hui Zhao; Ying Sun; Yi Deng; Chuanyue Wu ABSTRACT Cell migration involves front-to-rear asymmetric focal adhesion (FA) dynamics, which...
Includes: Supplementary data
Journal Articles
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Adhesion
J Cell Sci (2020) 133 (18): jcs243683.
Published: 23 September 2020
...Anna V. Samarelli; Tilman Ziegler; Alexander Meves; Reinhard Fässler; Ralph T. Böttcher ABSTRACT Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs248583.
Published: 05 August 2020
... positions in WT animals, AQR localized at a more posterior position, and PQR was confined to a more anterior region in spc-1(cas971) or unc-70(cas983) or in somatic CRISPR-Cas9-created spc-1 conditional mutants, indicating an essential role of spectrin in cell migration ( Fig. 1 B; Fig. S1A ). The...
Includes: Supplementary data
Journal Articles
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Cytoskeleton
J Cell Sci (2020) 133 (11): jcs242842.
Published: 11 June 2020
... (GR, also known as NR3C1) to regulate immunity, energy metabolism and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. Here, we show that GCs rapidly inhibit cell migration, in...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241505.
Published: 11 May 2020
... cytoplasmic protrusions and increased cell migration. EML4–ALK V3 also recruits the NEK9 and NEK7 kinases to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4, as well as constitutive activation of NEK9, also perturbs cell morphology and accelerates migration in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs236778.
Published: 28 April 2020
... complex 3D environments and reveals a fundamentally new function for membrane blebs in cancer cell invasion. Membrane bleb Integrin ECM reorganization Cancer Cell migration Aberrant migratory and invasive behavior of cancer cells underlies metastatic dissemination, and limited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235325.
Published: 30 March 2020
... contractility Apical constriction Cell migration Drosophila Pulsed contractions During development, morphogenetic processes ultimately shape the organism ( Lecuit and Le Goff, 2007 ). Such processes are driven by various cell behaviours, e.g. intercalation ( Bertet et al., 2004 ; Irvine and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238048.
Published: 06 March 2020
... SDF-1α ( Fig. 6 B). It is noteworthy that the levels of ICAM-1 receptors were not changed in cofilin1-deficient thymocytes, as shown by FACS analysis of LFA-1 subunit chains CD11a and CD18 ( Fig. S1A ). Adhesion and spreading are crucial for cell migration. Most cells go through cycles of...
Journal Articles
J Cell Sci (2020) 133 (4): jcs242834.
Published: 21 February 2020
... minimize the negative effects of IO for live imaging. Fluorescence microscopy Phototoxicity Cell migration Mitochondrial dynamics Microtubule dynamics Adhesion dynamics Fluorescence microscopy provides a convenient, selective and sensitive way to observe living systems. Although modern...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2020) 133 (3): jcs233361.
Published: 04 February 2020
...Kuan-Jung Chen; Tsai-Chen Chiang; Chia-Jung Yu; Fang-Jen S. Lee ABSTRACT Cell migration requires the coordination of multiple signaling pathways involved in membrane dynamics and cytoskeletal rearrangement. The Arf-like small GTPase Arl4A has been shown to modulate actin cytoskeleton remodeling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (24): jcs236828.
Published: 13 December 2019
... mediate numerous functions, including cell–matrix adhesion, extracellular matrix degradation, mechanosensing and cell migration. Podosomes present as micron-sized F-actin cores surrounded by an adhesive ring of integrins and integrin–actin linkers, such as talin and vinculin. In this Review, we highlight...
Journal Articles
J Cell Sci (2019) 132 (11): jcs233387.
Published: 07 June 2019
.... Silencing of GGA2 limits active β1-integrin levels in focal adhesions and decreases cancer cell migration and invasion, which is in agreement with its ability to regulate the dynamics of active integrins. By using the proximity-dependent biotin identification (BioID) method, we identified two RAB family...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs225565.
Published: 11 February 2019
...Juan Manuel Garcia-Arcos; Renaud Chabrier; Mathieu Deygas; Guilherme Nader; Lucie Barbier; Pablo José Sáez; Aastha Mathur; Pablo Vargas; Matthieu Piel ABSTRACT Single cells migrate in a myriad of physiological contexts, such as tissue patrolling by immune cells, and during neurogenesis and tissue...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs216168.
Published: 29 October 2018
... cancer-derived cells via enhancement of tubulin acetylation and Akt activation. Calmodulin-regulated spectrin-associated protein 3 CAMSAP3 Cell migration Epithelial-to-mesenchymal transition EMT Protein kinase B Akt Tubulin acetylation Metastasis remains a major obstacle for cancer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs218222.
Published: 11 October 2018
...David Gau; Partha Roy ABSTRACT Actin-based cell migration is a fundamental cellular activity that plays a crucial role in a wide range of physiological and pathological processes. An essential feature of the remodeling of actin cytoskeleton during cell motility is the de novo synthesis of factors...
Journal Articles
In collection:
Cell Migration
J Cell Sci (2018) 131 (16): jcs216317.
Published: 20 August 2018
... kinase inhibited it. Inhibitors of focal adhesion kinase and Cdc42 had negligible effects. Hence, initial actin polymerization occurs in the lateral membrane, and is primarily important to initiate dead cell exfoliation and cell migration to close the gap. * Authors for correspondence ( aiharaeo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs216408.
Published: 16 August 2018
... phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. Here we show, through depletion of SHIP2 in triple negative MDA-MB-231 cells and the use of SHIP2 inhibitors, that cell migration appears to be positively controlled...
Includes: Supplementary data