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Keywords: Cell migration
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... calibration of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs259226.
Published: 14 March 2022
...Jan Faix; Klemens Rottner ABSTRACT The tightly coordinated, spatiotemporal control of actin filament remodeling provides the basis of fundamental cellular processes, such as cell migration and adhesion. Specific protein assemblies, composed of various actin-binding proteins, are thought to operate...
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... as a novel regulator of WAVE controlling cell shape and motility in immune response. Basal phosphorylation of WAVE by CK1α protects it from premature proteasomal degradation. Drosophila Macrophages Cell migration Cell shape Lamellipodia Cell motility Actin Arp2/3 WAVE CK1α CK2...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (18): jcs259221.
Published: 24 September 2021
... TRPML1 (also known as MCOLN1), enabling the local activation of myosin II at the cell rear. Taken together, our findings identify Rab7b as the missing physical link between lysosomes and the actomyosin cytoskeleton, allowing control of immune cell migration through lysosomal signaling. This article has...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs258574.
Published: 22 April 2021
... biosensors in the knockout background. As a proof-of-principle, we inactivated the rac2 gene. Rac2 is essential for actin polymerization, cell migration and intracellular signaling. Loss of Rac2 activity leads to defects in neutrophil motility and chemotaxis in zebrafish ( Deng et al., 2011 ; Rosowski et...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (6): jcs254359.
Published: 29 March 2021
...Zofia Ostrowska-Podhorodecka; Isabel Ding; Wilson Lee; Jelena Tanic; Sevil Abbasi; Pamma D. Arora; Richard S. Liu; Alison E. Patteson; Paul A. Janmey; Christopher A. McCulloch ABSTRACT Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (6): jcs240226.
Published: 22 March 2021
..., and the mechanobiological responses of pericytes to these forces. Pericyte Cytoskeleton Contractility Cell migration Cell mechanics In vitro models Pericytes are mural cells of the microvasculature that are embedded in the vessel basement membrane (BM), where they surround endothelial cells (ECs...
Journal Articles
J Cell Sci (2021) 134 (1): jcs244616.
Published: 13 January 2021
...Jie Liu; Zhongzhen Liu; Keng Chen; Wei Chen; Xiyuan Fang; Meng Li; Xuening Zhou; Ning Ding; Huan Lei; Chen Guo; Tao Qian; Yilin Wang; Lin Liu; Yonglong Chen; Hui Zhao; Ying Sun; Yi Deng; Chuanyue Wu ABSTRACT Cell migration involves front-to-rear asymmetric focal adhesion (FA) dynamics, which...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (18): jcs243683.
Published: 23 September 2020
...Anna V. Samarelli; Tilman Ziegler; Alexander Meves; Reinhard Fässler; Ralph T. Böttcher ABSTRACT Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs248583.
Published: 5 August 2020
... or conditional unc-44 mutants generated by somatic CRISPR-Cas9 ( Fig. 4 D), we showed that the loss of UNC-44 reduced Q cell migration in adult animals and disrupted the neurites in Q cell progenies, as observed for those in the spectrin mutant animals ( Fig. 4 H). By creating an UNC-44::GFP KI animal, we...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (11): jcs242842.
Published: 11 June 2020
... (GR, also known as NR3C1) to regulate immunity, energy metabolism and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. Here, we show that GCs rapidly inhibit cell migration...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241505.
Published: 11 May 2020
... cytoplasmic protrusions and increased cell migration. EML4–ALK V3 also recruits the NEK9 and NEK7 kinases to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4, as well as constitutive activation of NEK9, also perturbs cell morphology and accelerates migration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs236778.
Published: 28 April 2020
... in complex 3D environments and reveals a fundamentally new function for membrane blebs in cancer cell invasion. Membrane bleb Integrin ECM reorganization Cancer Cell migration Aberrant migratory and invasive behavior of cancer cells underlies metastatic dissemination, and limited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235325.
Published: 30 March 2020
... morphogenesis, the larval epithelial cells transit from migration to constriction. A change in the polarity of their pulsatile cytoskeletal network and tightly controlled cellular contractility underlie this transition. Actomyosin contractility Apical constriction Cell migration Drosophila Pulsed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238048.
Published: 6 March 2020
... to circumvent the migration-dependent differentiation block by providing the relevant external signals in vitro . This should then allow cofilin1-depleted DP thymocytes to differentiate towards SP thymocytes. In conclusion, our results provide new insights into the role of cofilin1 in 3-D cell migration...
Journal Articles
J Cell Sci (2020) 133 (4): jcs242834.
Published: 21 February 2020
... the negative effects of IO for live imaging. Fluorescence microscopy Phototoxicity Cell migration Mitochondrial dynamics Microtubule dynamics Adhesion dynamics Fluorescence microscopy provides a convenient, selective and sensitive way to observe living systems. Although modern microscopes...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2020) 133 (3): jcs233361.
Published: 4 February 2020
...Kuan-Jung Chen; Tsai-Chen Chiang; Chia-Jung Yu; Fang-Jen S. Lee ABSTRACT Cell migration requires the coordination of multiple signaling pathways involved in membrane dynamics and cytoskeletal rearrangement. The Arf-like small GTPase Arl4A has been shown to modulate actin cytoskeleton remodeling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (24): jcs236828.
Published: 13 December 2019
.... They mediate numerous functions, including cell–matrix adhesion, extracellular matrix degradation, mechanosensing and cell migration. Podosomes present as micron-sized F-actin cores surrounded by an adhesive ring of integrins and integrin–actin linkers, such as talin and vinculin. In this Review, we highlight...
Journal Articles
J Cell Sci (2019) 132 (11): jcs233387.
Published: 7 June 2019
.... Silencing of GGA2 limits active β1-integrin levels in focal adhesions and decreases cancer cell migration and invasion, which is in agreement with its ability to regulate the dynamics of active integrins. By using the proximity-dependent biotin identification (BioID) method, we identified two RAB family...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs225565.
Published: 11 February 2019
...Juan Manuel Garcia-Arcos; Renaud Chabrier; Mathieu Deygas; Guilherme Nader; Lucie Barbier; Pablo José Sáez; Aastha Mathur; Pablo Vargas; Matthieu Piel ABSTRACT Single cells migrate in a myriad of physiological contexts, such as tissue patrolling by immune cells, and during neurogenesis and tissue...
Includes: Supplementary data