... this, we first investigated the distribution of ZO-1 as a marker for TJs, and E-cadherin as a marker for adherens junctions (AJs) in WT and KO cysts. Next, we analyzed the cell–cell junctions in 3D cysts for potential changes in their structure by transmission electron microscopy (TEM). The apical...

... development. Epidermis Skin Tumorigenesis Polarity Cell junction Cell adhesion Mitotic spindle orientation Epithelial organization National Institutes of Health 10.13039/100000002 R01AR072590 R01CA225463 Non-melanoma skin cancer, which includes basal cell carcinoma (BCC...

...Siu P. Ngok; Rory Geyer; Antonis Kourtidis; Natalia Mitin; Ryan Feathers; Channing Der; Panos Z. Anastasiadis Summary Signaling events mediated by Rho family GTPases orchestrate cytoskeletal dynamics and cell junction formation. The activation of Rho GTPases is tightly regulated by guanine...

...-catenin complex and intermediate filaments, the binding of αT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells. This could explain the devastating effect of plakophilin-2 mutations on cell junction stability in intercalated...

... of Biologists Limited 2004 2004 Trypanosome Flagellum Morphogenesis Cell junction Flagella connector Cytotaxis Trypanosomatid parasites are the aetiological agents of several important human diseases, including sleeping sickness in Africa ( Trypanosoma brucei ), Chagas disease in Central...

... was not localized to the tight junctions. Because CEACAM1-L participates in homophilic cell-cell adhesion at the lateral surfaces of polarized MDCK cells, it was of interest to investigate how it relates to and possibly affects other adhesive molecules and cell junctions in the lateral membranes. We therefore...

... localization of Shank proteins at postsynaptic sites of brain excitatory synapses suggests a role for this family of proteins in the organization of cytoskeletal/ signaling complexes at specialized cell junctions. REFERENCES Boeckers , T. M. , Kreutz , M. R. , Winter , C. , Zuschratter , W...

... 1995 by Company of Biologists 1995 targeting transmembrane protein synaptic vesicle cell junction synaptophysin connexin The ordered structure of cells relies on the sorting and assembly of their polypeptide components into specialized membrane-bound compartments. Selective...

... sites occupied by the MTOCs and link microtubule ends to cell junctions. This procedure also connects the microtubule bundle to cytoskeletal arrays in neighbouring cells at two of the MTOC sites, and to the basilar membrane (a substantial basement membrane) in the case of the third site. A fourth...

... of Biologists 1988 actin cytoskeleton microtubule cell junction Drosophila Filaments with diameters of 6 nm are concentrated within bundles of microtubules in the epidermal cells of Drosophila wing blades during the final stages of pupal development. Filament diameters correspond...

..., the submembrane skeletal scaffold regulates membrane fusion by limiting its occurrence, and the extent of its occurrence. 02 06 1984 29 08 1984 © 1985 by Company of Biologists 1985 cytoskeleton membrane fusion conjugation Tetrahymena cell junction Cell fusion is an important...