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Keywords: Cell fate
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Journal Articles
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Stem Cells
J Cell Sci (2021) 134 (9): jcs252767.
Published: 11 May 2021
.... The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs218107.
Published: 11 August 2020
... as the unfolded protein response (UPR), triggering adaptive programs or apoptosis of terminally damaged cells. IRE1α (also known as ERN1), the most conserved UPR sensor, mediates the activation of responses to determine cell fate under ER stress. The complexity of IRE1α regulation and its signaling outputs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3590–3600.
Published: 01 August 2012
... related to non-muscle cell fates, such as chondrogenesis, was activated. This indicates that the concerted downregulation of multiple microRNA targets is not only crucial to the skeletal muscle differentiation program but also serves to prevent alternative cell fate choices. *Present address...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2553–2560.
Published: 01 June 2012
...Kazutoshi Takahashi During development, cell fate is specified precisely through programming by multiple complex elements and processes, including chromatin modifications that result in epigenetic marks. Once determined, cell fate is specified further only through maturation processes, which...
Journal Articles
J Cell Sci (2010) 123 (13): 2145–2154.
Published: 01 July 2010
... studies in mouse models indicate that the effect of ERSS in vivo and the nature of the cellular strategies induced to ameliorate pathological ER stress are crucial factors in determining cell fate and clinical disease features. Importantly, ERSS can affect cellular proliferation and the differentiation...
Journal Articles
J Cell Sci (2009) 122 (2): 171–177.
Published: 15 January 2009
..., new literature demonstrates that integrins control the cell-division axis at mitosis. This extends the influence of integrins over cell-fate decisions, as daughter cells are frequently located in new microenvironments that determine their behaviour following cell division. In this Commentary, I...
Journal Articles
J Cell Sci (2008) 121 (9): 1373–1382.
Published: 01 May 2008
... muscle. * Author for correspondence (e-mail: peter.zammit@kcl.ac.uk ) 26 1 2008 © The Company of Biologists Limited 2008 2008 Satellite cell Stem cell Skeletal muscle β-catenin Pax7 MyoD Cell fate Self-renewal Homeostasis, hypertrophy and repair of adult skeletal...
Journal Articles
J Cell Sci (2005) 118 (1): 223–232.
Published: 01 January 2005
... ). * Author for correspondence (e-mail: masako@paru.cas.cz ) 26 10 2004 © The Company of Biologists Limited 2005 2005 Caenorhabditis elegans Epidermis Cell motility Cell fate Nuclear receptor NHR-25/FTZ-F1 Developmental processes involve shape changes of epithelial cells...
Journal Articles
J Cell Sci (2002) 115 (7): 1355–1359.
Published: 01 April 2002
...Hideyuki Okano; Takao Imai; Masataka Okabe Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification...
Journal Articles
J Cell Sci (2001) 114 (21): 3923–3932.
Published: 01 November 2001
... of Biologists Limited 2001 2001 ABC Multidrug pH Cell-type choice Cell fate Musical chairs Little is known about how a set of undifferentiated cells can break symmetry and differentiate into distinct cell types. One of the simplest organisms that exhibits this behavior is the eukaryote...