... advancements in the field of IFs, exploring their general features, functions beyond structural support, and involvement in diseases. Intermediate filaments Cytoskeleton Cell fate Classification and function Disease Structure Academy of Finland http://dx.doi.org/10.13039/501100002341...

... – the primary cilium – as a sensory antenna, have since been extensively studied, but the role of the cilium–centrosome axis in cell fate is still emerging. In this Opinion piece, we view cellular quiescence and tissue homeostasis from the vantage point of the cilium–centrosome axis. We focus on a less explored...

.... The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous effectors of stem cell fate and whether they act through translational control remains obscure...

... as the unfolded protein response (UPR), triggering adaptive programs or apoptosis of terminally damaged cells. IRE1α (also known as ERN1), the most conserved UPR sensor, mediates the activation of responses to determine cell fate under ER stress. The complexity of IRE1α regulation and its signaling outputs...

... related to non-muscle cell fates, such as chondrogenesis, was activated. This indicates that the concerted downregulation of multiple microRNA targets is not only crucial to the skeletal muscle differentiation program but also serves to prevent alternative cell fate choices. References Akimoto   T...

...Kazutoshi Takahashi During development, cell fate is specified precisely through programming by multiple complex elements and processes, including chromatin modifications that result in epigenetic marks. Once determined, cell fate is specified further only through maturation processes, which...

... studies in mouse models indicate that the effect of ERSS in vivo and the nature of the cellular strategies induced to ameliorate pathological ER stress are crucial factors in determining cell fate and clinical disease features. Importantly, ERSS can affect cellular proliferation and the differentiation...

..., new literature demonstrates that integrins control the cell-division axis at mitosis. This extends the influence of integrins over cell-fate decisions, as daughter cells are frequently located in new microenvironments that determine their behaviour following cell division. In this Commentary, I...

... muscle. * Author for correspondence (e-mail: [email protected] ) 26 1 2008 © The Company of Biologists Limited 2008 2008 Satellite cell Stem cell Skeletal muscle β-catenin Pax7 MyoD Cell fate Self-renewal Homeostasis, hypertrophy and repair of adult skeletal...

...-Sang and Chisholm, 2000 ; Simske and Hardin, 2001 ). Considerably less is known about the regulation of cellular movements that shape C. elegans epidermis during the postembryonic development. Caenorhabditis elegans Epidermis Cell motility Cell fate Nuclear receptor NHR-25/FTZ-F1...

...Hideyuki Okano; Takao Imai; Masataka Okabe Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification...

... of stalk cells supporting a mass of spore cells. ABC Multidrug pH Cell-type choice Cell fate Musical chairs © The Company of Biologists Limited 2001 2001 19 7 2001 ‡Author for correspondence (e-mail: [email protected] ) References Araki, T., Nakao, H...

...Yu Cheng; Soyan Leung; Dimitra Mangoura ABSTRACT Excitatory and inhibitory neuronal cell fates require specific expression of both neurotransmitter and morphological phenotypes. The role of the F-actin cytoskeleton in morphological phenotypes has been well documented, but its role...

... to exogenous Sonic Hedgehog peptide. We find that Sonic Hedgehog peptide can control the binary cell fate choice of embryonic zebrafish myoblasts in vitro. We have also used this culture system to assay the relative activities of different Hedgehog-family proteins and to investigate the possible involvement...