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Keywords: Cell death
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Journal Articles
J Cell Sci (2022) 135 (20): jcs250134.
Published: 20 October 2022
...Sandy B. Serizier; Jeanne S. Peterson; Kimberly McCall ABSTRACT The last step of cell death is cell clearance, a process critical for tissue homeostasis. For efficient cell clearance to occur, phagocytes and dead cells need to reciprocally signal to each other. One important phenomenon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259629.
Published: 26 July 2022
.... Mechanistically, VRB and cortisone signaled through the integrated stress response mediated by eIF2α (also known as EIF2S1), yet induced different kinases, with cortisone activating the GCN2 kinase (also known as EIF2AK4). Cortisone increased VRB-induced cell death and reduced the population of cells trapped...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (5): jcs258644.
Published: 31 January 2022
...Adi Zheng; Gilles Dubuis; Maria Georgieva; Carla Susana Mendes Ferreira; Marc Serulla; Maria del Carmen Conde Rubio; Evgeniya Trofimenko; Thomas Mercier; Laurent Decosterd; Christian Widmann ABSTRACT High-density lipoproteins (HDLs) prevent cell death induced by a variety of cytotoxic drugs...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2021) 134 (24): jcs258966.
Published: 16 December 2021
... caspase-triggered apoptosis execution. Cell-to-cell heterogeneity Cell death Apoptosis Mcl-1 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 EXC 2075 390740016 MO 3226/1-1 MO 3226/4-1 SCHE349/10-1 EXC 310/2 Healthy development and physiological...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (23): jcs226241.
Published: 30 November 2018
... (OPTN) to ubiquitylated lysosomes. In addition, we observed that LC3 (MAP1LC3B) recruitment to damaged lysosomes was dependent on TBK1 activity. In these fibrillar AS-treated cells, autophagy inhibition impairs mitochondrial function and leads to microglial cell death. Our results suggest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 5 October 2018
... chronic stress in a human cell line and mouse embryonic fibroblasts. Surprisingly, we found that SGs that form under chronic nutrient starvation lack 40S ribosomes, do not actively exchange their constituent components with cytoplasmic pools and promote cell death. We named these SGs starvation-induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs215152.
Published: 20 September 2018
...Shani Bialik; Santosh K. Dasari; Adi Kimchi ABSTRACT Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of ‘Type II autophagic cell death’ in 1990. However, this phenomenon later came into question, because the presence of autophagosomes in dying cells does...
Journal Articles
J Cell Sci (2017) 130 (23): 3955–3963.
Published: 1 December 2017
... to a particular form of cell death called pyroptosis. Mutations in genes that encode inflammasome components are associated with many inflammatory disorders, and studies in the past decade have highlighted the importance of appropriate activation of the inflammasome in homeostasis and disease pathogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 2984–2995.
Published: 15 September 2017
..., the γH2Av response has also been reported in dying cells, where it requires activation of caspase-activated DNases (CADs). Moreover, caspases are known to be required downstream of DNA damage for cell death execution. We show here, for the first time, that the Drosophila initiator caspase Dronc acts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 502–511.
Published: 15 January 2017
...Ying Hou; Lindsey A. Allan; Paul R. Clarke ABSTRACT Regulation of cell death is crucial for the response of cancer cells to drug treatments that cause arrest in mitosis, and is likely to be important for protection against chromosome instability in normal cells. Prolonged mitotic arrest can result...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3385–3395.
Published: 15 September 2016
... bacterial aggregates are formed that can be extruded out of the tissue after cell death. Alternatively, these excessively infected cells can undergo necrosis leading to immediate recruitment of surrounding leukocytes and subsequent phagocytosis of released bacteria. Our data show that these necrotic burst...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4526–4537.
Published: 15 December 2015
... colony formation and tumor growth in xenograft assays in a PP1-dependent manner. Our data show that the selective inhibition of PP1 can be used to induce cancer cell death through mitotic catastrophe. * Author for correspondence ( Mathieu.Bollen@med.kuleuven.be ) Competing interests...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1507–1517.
Published: 15 April 2015
..., we report that p75 NTR signals very differently in hippocampal neurons (HCNs) and cerebellar granule neurons (CGNs), and we present evidence indicating that this is partly controlled by differential proteolytic cleavage. Nerve growth factor (NGF) induced caspase‐3 activity and cell death in HCNs...
Journal Articles
J Cell Sci (2014) 127 (19): 4134–4145.
Published: 1 October 2014
...(ADP-ribose) polymerase-1 (PARP1) has also emerged. Genotoxic stresses, such as oxidants and alkylating agents, have long been known to cause necrotic cell death that is associated with an overstimulation of PARP1 ( Hassa, 2009 ). Moreover, ischemia/reperfusion-induced myocardial and cerebral necrosis...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (17): 3817–3829.
Published: 1 September 2014
...A. Pedro Gonçalves; J. Miguel Cordeiro; João Monteiro; Alberto Muñoz; Paulo Correia-de-Sá; Nick D. Read; Arnaldo Videira ABSTRACT The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1229–1241.
Published: 15 March 2014
... cells by phagocytes.   Cell Death Differ.   5 , 551 – 562 . 10.1038/sj.cdd.4400404 Farhadifar   R. , Röper   J. C. , Aigouy   B. , Eaton   S. , Jülicher   F. ( 2007 ). The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing.   Curr. Biol...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2004–2013.
Published: 1 May 2013
... of both RB and TSC2 induces synergistic apoptosis during the development of Drosophila melanogaster and in cancer cells. However, the in vivo mechanism of this synthetic-lethal interaction is not clear. Here, we show that synergistic cell death in tissues that have lost the RB and TSC orthologs rbf...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5259–5268.
Published: 15 November 2012
... ). Systems biology analysis of programmed cell death.   Trends Biochem. Sci.   35 , 556 – 564 . 10.1016/j.tibs.2010.04.008 Boya   P. , Kroemer   G. ( 2009 ). Beclin 1: a BH3-only protein that fails to induce apoptosis.   Oncogene   28 , 2125 – 2127 . 10.1038/onc.2009.83 Boya   P...
Journal Articles
J Cell Sci (2012) 125 (7): 1796–1806.
Published: 1 April 2012
... a crucial role for mitochondrial dysfunction in seizure-activity-induced neuronal death, and that strategies aimed at redressing this are neuroprotective. * Author for correspondence ( a.abramov@ucl.ac.uk ) 20 11 2011 © 2012. 2012 Cell death Seizure Status epilepticus Mitochondria...
Journal Articles
J Cell Sci (2012) 125 (4): 807–815.
Published: 15 February 2012
.... Mitochondria perform various signalling functions, serving as platforms to initiate cell signalling, as well as acting as transducers and effectors in multiple processes. Here, we discuss the active roles that mitochondria have in cell death signalling, innate immunity and autophagy. Common themes...