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Keywords: Cell death
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Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (23): jcs226241.
Published: 30 November 2018
... (OPTN) to ubiquitylated lysosomes. In addition, we observed that LC3 (MAP1LC3B) recruitment to damaged lysosomes was dependent on TBK1 activity. In these fibrillar AS-treated cells, autophagy inhibition impairs mitochondrial function and leads to microglial cell death. Our results suggest that...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 05 October 2018
... chronic stress in a human cell line and mouse embryonic fibroblasts. Surprisingly, we found that SGs that form under chronic nutrient starvation lack 40S ribosomes, do not actively exchange their constituent components with cytoplasmic pools and promote cell death. We named these SGs starvation-induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs215152.
Published: 20 September 2018
...Shani Bialik; Santosh K. Dasari; Adi Kimchi ABSTRACT Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of ‘Type II autophagic cell death’ in 1990. However, this phenomenon later came into question, because the presence of autophagosomes in dying cells does...
Journal Articles
J Cell Sci (2017) 130 (23): 3955–3963.
Published: 01 December 2017
... particular form of cell death called pyroptosis. Mutations in genes that encode inflammasome components are associated with many inflammatory disorders, and studies in the past decade have highlighted the importance of appropriate activation of the inflammasome in homeostasis and disease pathogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 2984–2995.
Published: 15 September 2017
... γH2Av response has also been reported in dying cells, where it requires activation of caspase-activated DNases (CADs). Moreover, caspases are known to be required downstream of DNA damage for cell death execution. We show here, for the first time, that the Drosophila initiator caspase Dronc acts as an...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 502–511.
Published: 15 January 2017
...Ying Hou; Lindsey A. Allan; Paul R. Clarke ABSTRACT Regulation of cell death is crucial for the response of cancer cells to drug treatments that cause arrest in mitosis, and is likely to be important for protection against chromosome instability in normal cells. Prolonged mitotic arrest can result...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2016) 129 (18): 3385–3395.
Published: 15 September 2016
... with large bacterial aggregates are formed that can be extruded out of the tissue after cell death. Alternatively, these excessively infected cells can undergo necrosis leading to immediate recruitment of surrounding leukocytes and subsequent phagocytosis of released bacteria. Our data show that these...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4526–4537.
Published: 15 December 2015
... colony formation and tumor growth in xenograft assays in a PP1-dependent manner. Our data show that the selective inhibition of PP1 can be used to induce cancer cell death through mitotic catastrophe. * Author for correspondence ( Mathieu.Bollen@med.kuleuven.be ) Competing interests The...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1507–1517.
Published: 15 April 2015
..., we report that p75 NTR signals very differently in hippocampal neurons (HCNs) and cerebellar granule neurons (CGNs), and we present evidence indicating that this is partly controlled by differential proteolytic cleavage. Nerve growth factor (NGF) induced caspase‐3 activity and cell death in HCNs but...
Journal Articles
J Cell Sci (2014) 127 (19): 4134–4145.
Published: 01 October 2014
... activates PARP causing astrocytic metabolic failure and neuronal death.   Brain   134 , 1658 – 1672 . 10.1093/brain/awr104 Alano   C. C. , Ying   W. , Swanson   R. A. ( 2004 ). Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD + depletion and mitochondrial...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (17): 3817–3829.
Published: 01 September 2014
...A. Pedro Gonçalves; J. Miguel Cordeiro; João Monteiro; Alberto Muñoz; Paulo Correia-de-Sá; Nick D. Read; Arnaldo Videira ABSTRACT The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1229–1241.
Published: 15 March 2014
... phase. First, we imaged UV-exposed MDCK-cell monolayers stably expressing GFP-tagged myosin regulatory light chain (MRLC). Prior to any evidence of cell death, MRLC–GFP fluorescence was cytoplasmic, with a slight enrichment at the basal plane in focal adhesions (0 min, Fig. 6A ; supplementary material...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2004–2013.
Published: 01 May 2013
... both RB and TSC2 induces synergistic apoptosis during the development of Drosophila melanogaster and in cancer cells. However, the in vivo mechanism of this synthetic-lethal interaction is not clear. Here, we show that synergistic cell death in tissues that have lost the RB and TSC orthologs rbf and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (22): 5259–5268.
Published: 15 November 2012
.... * Author for correspondence ( adi.kimchi@weizmann.ac.il ) © 2012. Published by The Company of Biologists Ltd 2012 Apoptosis Autophagy Cancer Cell death Crosstalk The evolutionary transition to multicellularity has dictated the emergence of a highly controlled genetic program of...
Journal Articles
J Cell Sci (2012) 125 (7): 1796–1806.
Published: 01 April 2012
... crucial role for mitochondrial dysfunction in seizure-activity-induced neuronal death, and that strategies aimed at redressing this are neuroprotective. We further hypothesised that ATP depletion in conditions of low Mg 2+ can induce cell death after a long exposure. There was no significant difference...
Journal Articles
J Cell Sci (2012) 125 (4): 807–815.
Published: 15 February 2012
.... Mitochondria perform various signalling functions, serving as platforms to initiate cell signalling, as well as acting as transducers and effectors in multiple processes. Here, we discuss the active roles that mitochondria have in cell death signalling, innate immunity and autophagy. Common themes of...
Journal Articles
J Cell Sci (2011) 124 (17): 2951–2963.
Published: 01 September 2011
.... Moreover, the mechanism of the decision of cell death modalities following MC is still not well characterised. We demonstrate here a crucial role of the γH2AX–ATM–p53 pathway in the regulation of the apoptotic outcome of MC resulting from cells entering mitosis with damaged DNA. In addition to p53...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (2): 161–170.
Published: 15 January 2011
... and the mechanisms of phagophore expansion and autophagosome formation, how the network of TOR signaling pathways regulating autophagy are controlled, and what the underlying mechanisms are for the pro-cell survival and the pro-cell death effects of autophagy. As several recent reviews have...
Journal Articles
J Cell Sci (2011) 124 (2): 216–227.
Published: 15 January 2011
... p38 MAPKs are implicated in many cellular processes including inflammation, differentiation, cell growth, cell cycle and cell death. The function of p38 MAPKs in mitotic entry has been well established, but their role in mitotic progression has remained controversial. We identify p38γ MAPK as a...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (18): 3330–3339.
Published: 15 September 2009
... treatment of pathological conditions in which manipulation of autophagic flux is thought to be beneficial. ‡ Author for correspondence ( gm89@le.ac.uk ) * These authors contributed equally to this work 30 6 2009 © The Company of Biologists Limited 2009 2009 LC3 Cell death...
Includes: Supplementary data