... response (DDR). In mammals, Chk1 also controls cellular proliferation even in the absence of exogenous DNA damage. However, little is known about how Chk1 regulates unperturbed cell cycle progression, and how this effect under physiological conditions differs from its regulatory role in DDR. Here, we have...

... © 2015. Published by The Company of Biologists Ltd 2015 DNA damage response ATR UVB light Cell cycle progression Replication arrest Translesion synthesis Ultraviolet light (UV) damages DNA through the induction of pyrimidine dimers (Beukers and Berends, 1960 ; Setlow and Carrier...

... of biological processes. Here, we demonstrate a crucial role of CUL4B in driving cell cycle progression. We show that loss of CUL4B results in a significant reduction in cell proliferation and causes G1 cell cycle arrest, accompanied by the upregulation of the cyclin-dependent kinase (CDK) inhibitors (CKIs) p21...

...-dependency, suggesting that cell spreading per se is not required as long as cyclin D is otherwise induced. We investigated whether cyclin D expression in cells exiting mitosis is sufficient to drive morphology-independent cell cycle progression in continuously cycling (i.e. not quiescent) cells. Disruption...

...Sabine Adolph; Sabine Brüsselbach; Rolf Müller ABSTRACT We have analysed the role of RNA polymerase II-depen-dent transcription in cell cycle progression. Time-lapse video recording and cytogenetic analysis were used to determine the sensitivity of NIH3T3 cells to the RNA polymerase II inhibitor...