... of nuclear localization of the transcription factor enhancer of zeste homolog 2. Histone modification Methyltransferase Transforming growth factor Polycomb repressive complex Cell contractility Matrix stiffness National Science Foundation http://dx.doi.org/10.13039/100000001 CMMI...

... of substrate stiffnesses and extracellular matrix components to understand their effects on myoblast contractility, which was found to be linked to proliferation. Myoblast Substrate stiffness Nuclear envelope Cell contractility Extracellular matrix Mechanobiology Natural Sciences...

..., we reveal that ZIKV infection leads to increased contractility of host cells. Importantly, we investigated whether host cell contractility contributes to ZIKV infection efficacy, from both the intracellular and extracellular perspective. By performing drug perturbation and gene editing experiments...

... adhesion composition as well as stiffness-induced FAK activation, which was linked with a distinctive increase in cell contractility, in experiments using both pharmacological and shRNA-based approaches. Additionally, the increased contractility could be reproduced in non-malignant cells upon TG2...

...-independent manner. ICAP-1 monoubiquitylation regulates rigidity sensing by increasing MRCKα (also known as CDC42BPA)-dependent cell contractility through myosin phosphorylation independently of substrate rigidity. We provide evidence that ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated...

... adhesion Cell contractility Contact inhibition of cell locomotion The present study is devoted to a new role of a protein p120 catenin (p120ctn) as a possible mediator of effects of cell-cell contact on the actin cytoskeleton and cell motility. p120ctn, a member of the Armadillo family...

...) microtubules would not be inhibitory. Therefore, microtubule poisons would promote actin microfilament organization and contractility; Lower panel: a change in microtubule dynamics alters the ability of MAPs to remain bound to the microtubules. Release of MAPs stimulates cell contractility and/or promotes...