... NOC1 as an essential gene in ribosome biogenesis and highlight its novel functions in the control of growth and cell competition. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: Maria Carmo-Fonseca...

..., the excessive accumulation of amyloid-β (Aβ) peptides triggers a complex cascade of pathological events underlying neuronal death, whose details are not yet completely understood. Our laboratory recently discovered that cell competition may play a protective role against AD by eliminating less fit neurons from...

..., growth of the dominant cell population is enhanced. In the tumor spheroid, such enhanced growth is accompanied by increased apoptosis in cells expressing less YAP. The cellular interaction during clonal dominance appears to be reminiscent of cell competition. RNA-seq analysis suggests...

...Hiroshi Mamada; Takashi Sato; Mitsunori Ota; Hiroshi Sasaki ABSTRACT Cell competition is a short-range communication originally observed in Drosophila . Relatively little is known about cell competition in mammals or in non-epithelial cells. Hippo signaling and its downstream transcription factors...

...). This is the first demonstration that an oncogenic transformation within an epithelium induces cell competition in a mammalian cell culture system. To examine the interaction between normal and Scribble-knockdown epithelial cells, we established MDCK epithelial cells stably expressing Scribble shRNA...