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Keywords: Cell adhesion
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Journal Articles
J Cell Sci (2022) 135 (6): jcs259226.
Published: 14 March 2022
... Actin dynamics Cell adhesion Cell migration Protrusion Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 FA330/9-2 GRK2223 © 2022. Published by The Company of Biologists Ltd 2022 Competing interests The authors declare no competing or financial...
Journal Articles
J Cell Sci (2021) 134 (24): jcs259012.
Published: 22 December 2021
... Vestweber ABSTRACT Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial cells and strongly stabilizes endothelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs259004.
Published: 15 September 2021
... to the underlying basement membrane. Integrin α6β4 is a receptor for laminins and plays a vital role in mediating cell adhesion by initiating the assembly of HDs. In addition, α6β4 has been implicated in signal transduction events that regulate diverse cellular processes, including proliferation and survival...
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2021) 134 (14): jcs258388.
Published: 22 July 2021
...–EC11 and can act as a flexible hinge. Our findings provide insights into diversification of classical cadherin-mediated adhesion mechanisms. This article has an associated First Person interview with the first author of the paper. Cadherin Cell adhesion Homophilic interactions Molecular structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (10): jcs255844.
Published: 20 May 2021
... and molecular characterization of myosin XIX (Myo19)-deficient cells reveals that different cellular and molecular processes are linked to mitochondrial dynamics regulated by Myo19. Cell adhesion Mitochondria Mitosis Myosin Mitochondria are DNA-containing membrane-limited organelles that cannot...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (2): jcs249078.
Published: 27 January 2021
.... PLEKHG4B Actin organization Cell adhesion Rho-GEF Myosin Annexin-A2 Cell–cell junctions regulate various structural and functional characteristics of cells, including morphology, polarity, motility, mechanical integrity, barrier function, proliferation and differentiation ( Garcia et al., 2018...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs242461.
Published: 11 December 2020
... of Biologists Ltd 2020 Summary: A Review of the mechanical tuning of growth factor signaling through crosstalk and interaction with mechanosensitive integrin cell adhesive receptors. EGFR Cancer Cell adhesion Integrin Mechanosensing Mechanotransduction Heterodimeric transmembrane...
Journal Articles
J Cell Sci (2020) 133 (23): jcs249102.
Published: 7 December 2020
...-dependent suppression of PAR3 (encoded by PARD3 ) accelerates epithelial disorganization during early tumorigenesis. Diminished PAR3 led to loss of E-cadherin-mediated cell adhesion, which in turn contributed to misoriented cell division. Pharmacological inhibition of the MAPK pathway downstream of RAS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... and invadopodia initiation and maturation, despite the differences in their morphology and functions. Cell adhesion Cell invasion Integrin adhesions Mechanosensing Focal adhesions Invadopodia Cell-matrix interactions are essential for the regulation of cell behavior and fate in multiple...
Journal Articles
J Cell Sci (2020) 133 (19): jcs239202.
Published: 12 October 2020
...; Jinhua Wu; Vesa P. Hytönen; Bernhard Wehrle-Haller ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs232702.
Published: 2 January 2020
...Carolina Diaz; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Dimitris Missirlis ABSTRACT The major fibronectin (FN)-binding α 5 β 1 and α v β 3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs235507.
Published: 23 August 2019
... cell adhesion. Some cytoplasmic cargo remains functional after transfer, as demonstrated with encapsidated genomes of measles virus (MeV). This virus uses nectin-4, but not nectin-1, as a receptor. Epithelial cells expressing nectin-4, but not those expressing another MeV receptor in its place, can...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2018) 131 (24): jcs225144.
Published: 18 December 2018
... domain of Talin allowing its recruitment to integrins at the plasma membrane. This process appears to be strictly required for integrin-mediated adhesion in Drosophila . Cell adhesion Drosophila Morphogenesis ECM Integrin Talin Rap1 The assembly and maintenance of tissue...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs215517.
Published: 8 November 2018
... the fact that continuous antigen recognition is required for efficient T cell activation ( Valitutti et al., 1995 ; Varma et al., 2006 ; Vardhana et al., 2010 ). T cell receptor TCR Cellular immune response Cytoskeleton Cell adhesion Cell signaling Adaptor protein ADAP SLP-76...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs221556.
Published: 31 October 2018
... junction protein claudin-4 drove interface formation between giant unilamellar vesicles. These interfaces were sufficient to act as molecular fences toward proteins but not lipids. Cell adhesion Epithelial cells Polarity Reconstitution Tight junction Transmembrane protein Nowhere...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2017) 130 (7): 1224–1231.
Published: 1 April 2017
... with reduced N-glycosylation than in the mock-treated embryos. In addition, among other deficiencies, we observed spindle orientation defects in two-cell embryos. Moreover, cell–cell adhesion was specifically lost at the two-cell stage when N-glycosylation was reduced. This loss-of-adhesion phenotype...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 344–359.
Published: 15 January 2017
... conserved functions in integrin receptor recycling and lysosome neutralization. Drosophila WASH Actin cytoskeleton Cell adhesion Lysosome neutralization Macrophages Arp2/3 Wiskott-Aldrich syndrome V-ATPase Integrin The Wiskott-Aldrich syndrome protein (WASP) family of nucleation...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 1 December 2016
...) has an intermediate effect]. The increased motility is associated with reduced cell adhesiveness, caused by loss of N-cadherin protein and RNA at the wound edge. This in turn causes a redistribution of N-cadherin-binding proteins (p120 catenin and β-catenin) to the cytosol and nucleus, respectively...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2016) 129 (17): 3309–3319.
Published: 1 September 2016
...Shigetaka Nishiguchi; Akira Yagi; Nobuaki Sakai; Hiroki Oda ABSTRACT Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell–cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and insect lineages. Of the five rod-like...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (15): 2962–2971.
Published: 1 August 2016
... in reduced numbers of focal adhesions and decreased adhesion to fibronectin. To understand how LAR regulates cell adhesion we used phosphoproteomic data, comparing global phosphorylation events in wild-type and LAR phosphatase-deficient cells, to analyse differential kinase activity. Kinase prediction...