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Keywords: Cell adhesion
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Journal Articles
J Cell Sci (2021) 134 (10): jcs255844.
Published: 20 May 2021
... epithelial and endothelial cells from the surface ( Li et al., 1999 ). ROS have also been shown to modulate the activity of phosphatases and kinases and thus, influence cell adhesion properties ( Li et al., 1999 ; Schieber and Chandel, 2014 ). Indeed, quenching of ROS in Myo19-deficient cells leads to a...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (2): jcs249078.
Published: 27 January 2021
.... PLEKHG4B Actin organization Cell adhesion Rho-GEF Myosin Annexin-A2 Cell–cell junctions regulate various structural and functional characteristics of cells, including morphology, polarity, motility, mechanical integrity, barrier function, proliferation and differentiation ( Garcia et al., 2018...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs242461.
Published: 11 December 2020
... suspension – might similarly stimulate this pro-malignant β1 integrin–Met signaling. EGF stimulation causes β1 integrin to be lost from from cell–cell adhesions ( Mukoyama et al., 2007 ), while EGFR inhibition on stiff surfaces where integrin signaling is active alone is sufficient to reduce contractility...
Journal Articles
J Cell Sci (2020) 133 (23): jcs249102.
Published: 07 December 2020
...-dependent suppression of PAR3 (encoded by PARD3 ) accelerates epithelial disorganization during early tumorigenesis. Diminished PAR3 led to loss of E-cadherin-mediated cell adhesion, which in turn contributed to misoriented cell division. Pharmacological inhibition of the MAPK pathway downstream of RAS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... mechanosensitive mechanisms drive focal adhesions and invadopodia initiation and maturation, despite the differences in their morphology and functions. Cell adhesion Cell invasion Integrin adhesions Mechanosensing Focal adhesions Invadopodia Cell-matrix interactions are essential for the...
Journal Articles
J Cell Sci (2020) 133 (19): jcs239202.
Published: 12 October 2020
...; Jinhua Wu; Vesa P. Hytönen; Bernhard Wehrle-Haller ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin head domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs232702.
Published: 02 January 2020
...Carolina Diaz; Stefanie Neubauer; Florian Rechenmacher; Horst Kessler; Dimitris Missirlis ABSTRACT The major fibronectin (FN)-binding α 5 β 1 and α v β 3 integrins exhibit cooperativity during cell adhesion, migration and mechanosensing, through mechanisms that are not yet fully resolved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs235507.
Published: 23 August 2019
... cell adhesion. Some cytoplasmic cargo remains functional after transfer, as demonstrated with encapsidated genomes of measles virus (MeV). This virus uses nectin-4, but not nectin-1, as a receptor. Epithelial cells expressing nectin-4, but not those expressing another MeV receptor in its place, can...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2018) 131 (24): jcs225144.
Published: 18 December 2018
... to the F0 domain of Talin allowing its recruitment to integrins at the plasma membrane. This process appears to be strictly required for integrin-mediated adhesion in Drosophila . Cell adhesion Drosophila Morphogenesis ECM Integrin Talin Rap1 The assembly and maintenance of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs215517.
Published: 08 November 2018
...-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP . EMBO J.   24 , 2331 - 2341 . 10.1038/sj.emboj.7600706 Lange , S. , Sylvester , M. , Schümann , M. , Freund , C. and Krause , E. ( 2010 ). Identification of phosphorylation-dependent interaction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs221556.
Published: 31 October 2018
... the tight junction protein claudin-4 drove interface formation between giant unilamellar vesicles. These interfaces were sufficient to act as molecular fences toward proteins but not lipids. Cell adhesion Epithelial cells Polarity Reconstitution Tight junction Transmembrane protein...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2017) 130 (7): 1224–1231.
Published: 01 April 2017
... variable in embryos with reduced N-glycosylation than in the mock-treated embryos. In addition, among other deficiencies, we observed spindle orientation defects in two-cell embryos. Moreover, cell–cell adhesion was specifically lost at the two-cell stage when N-glycosylation was reduced. This loss-of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 344–359.
Published: 15 January 2017
... has conserved functions in integrin receptor recycling and lysosome neutralization. Drosophila WASH Actin cytoskeleton Cell adhesion Lysosome neutralization Macrophages Arp2/3 Wiskott-Aldrich syndrome V-ATPase Integrin The Wiskott-Aldrich syndrome protein (WASP) family of...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (23): 4399–4410.
Published: 01 December 2016
...) has an intermediate effect]. The increased motility is associated with reduced cell adhesiveness, caused by loss of N-cadherin protein and RNA at the wound edge. This in turn causes a redistribution of N-cadherin-binding proteins (p120 catenin and β-catenin) to the cytosol and nucleus, respectively...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2016) 129 (17): 3309–3319.
Published: 01 September 2016
...Shigetaka Nishiguchi; Akira Yagi; Nobuaki Sakai; Hiroki Oda ABSTRACT Homophilic binding of E-cadherins through their ectodomains is fundamental to epithelial cell–cell adhesion. Despite this, E-cadherin ectodomains have evolved differently in the vertebrate and insect lineages. Of the five rod-like...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (15): 2962–2971.
Published: 01 August 2016
... reduced numbers of focal adhesions and decreased adhesion to fibronectin. To understand how LAR regulates cell adhesion we used phosphoproteomic data, comparing global phosphorylation events in wild-type and LAR phosphatase-deficient cells, to analyse differential kinase activity. Kinase prediction...
Journal Articles
In collection:
Adhesion , Imaging
J Cell Sci (2016) 129 (15): 2897–2904.
Published: 01 August 2016
...Sara N. Stahley; Emily I. Bartle; Claire E. Atkinson; Andrew P. Kowalczyk; Alexa L. Mattheyses ABSTRACT Desmosomes are macromolecular junctions responsible for providing strong cell–cell adhesion. Because of their size and molecular complexity, the precise ultrastructural organization of desmosomes...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (12): 2394–2406.
Published: 15 June 2016
... were removed by rinsing, and fresh medium with or without WT Sec-β 1 or Y199A Sec-β 1 was added to the cells. The formation of cell–cell contacts was monitored by acquiring images of the same fields on microwell dishes every 2 h. Cell–cell adhesion was quantified by calculating the percentage of...
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (8): 1605–1618.
Published: 15 April 2016
... assays. Complex formation with LPP is mandatory for these PR130-PP2A functions, as neither phenotype can be rescued by re-expression of a PR130 mutant that no longer binds to LPP. Our data highlight the importance of specific, locally recruited PP2A complexes in cell adhesion and migration dynamics...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (3): 477–482.
Published: 01 February 2016
... neighbours. E-cadherin trafficking Epithelial morphogenesis Cell adhesion Cell–cell adhesion physically links cells within stable cell sheets, while also contributing to dynamic morphogenetic events such as directional proliferation, cell sorting and cell shape regulation ( Stepniak et al...
Includes: Supplementary data