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Keywords: Cdc6
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Journal Articles
J Cell Sci (2016) 129 (7): 1429–1440.
Published: 1 April 2016
... is initiated during the cell cycle is not fully understood. By performing a proteomic analysis of transcription factors that bind RNA polymerase I during rDNA transcription initiation, we identified that the DNA replication initiator Cdc6 interacts with RNA polymerase I and its co-factors, and promotes rDNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (7): 1429–1440.
Published: 1 April 2016
... is initiated during the cell cycle is not fully understood. By performing a proteomic analysis of transcription factors that bind RNA polymerase I during rDNA transcription initiation, we identified that the DNA replication initiator Cdc6 interacts with RNA polymerase I and its co-factors, and promotes rDNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2482–2496.
Published: 15 July 2015
... acquire the competence to replicate DNA one hour after the first meiotic division by accumulating an essential factor of the replicative machinery, Cdc6. Here, we show that the turnover of Cdc6 is precisely regulated in oocytes to avoid inhibition of Cdk1. At meiosis resumption, Cdc6 is expressed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1336–1345.
Published: 15 March 2014
...Linda Clijsters; Rob Wolthuis ABSTRACT Cdc6 and Cdt1 initiate DNA replication licensing when cells exit mitosis. In cycling cells, Cdc6 is efficiently degraded from anaphase onwards as a result of APC/C–Cdh1 activity. When APC/C–Cdh1 is switched off again, at the end of G1 phase, Cdc6 could thus re...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (8): 1184–1191.
Published: 15 April 2009
...Nozomi Sugimoto; Kazumasa Yoshida; Yasutoshi Tatsumi; Takashi Yugawa; Mako Narisawa-Saito; Shou Waga; Tohru Kiyono; Masatoshi Fujita When human cells enter S-phase, overlapping differential inhibitory mechanisms downregulate the replication licensing factors ORC1, CDC6 and Cdt1. Such regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5875–5886.
Published: 15 November 2004
... . We have investigated regulation of the origin licensing factors Cdc6, Cdt1, Mcm2 and Geminin in human somatic and germ cells. Cdc6 and Cdt1 play an essential role in DNA replication initiation by loading the Mcm2-7 complex, which is required for unwinding the DNA helix, onto chromosomal origins...
Journal Articles
J Cell Sci (2001) 114 (11): 2027–2041.
Published: 1 June 2001
... of pre-replicative complexes resulting in chromatin being ‘licensed’ for DNA replication in the subsequent S phase. We have analysed regulation of the pre-replicative complex proteins ORC, Cdc6, and MCM in cycling and non-proliferating quiescent, differentiated and replicative senescent human cells...
Journal Articles
Journal Articles
J Cell Sci (1999) 112 (12): 2011–2018.
Published: 15 June 1999
... of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, UK 29 03 1999 26 05 1999 © 1999 by Company of Biologists 1999 DNA replication Licensing factor ORC Cdc6 RLF In eukaryotes the initiation of replication forks occurs at multiple replication origins scattered...
Journal Articles
J Cell Sci (1997) 110 (6): 753–763.
Published: 15 March 1997
...Corrella S. Detweiler; Joachim J. Li ABSTRACT CDC6 is essential for the initiation of DNA replication in the budding yeast Saccharomyces cerevisiae . Here we examine the timing of Cdc6p expression and function during the cell cycle. Cdc6p is expressed primarily between mitosis and Start...