1-20 of 48
Keywords: Cdc42
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2020) 133 (11): jcs240283.
Published: 11 June 2020
... in a complex assembly pathway that culminates in the outgrowth of a new daughter cell. During recruitment, septin rods follow the high concentration of Cdc42 GTP that is generated by the focused localization of the Cdc42 guanine-nucleotide-exchange factor Cdc24. We show that, shortly before budding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238337.
Published: 13 March 2020
... previously undescribed polybasic motif that is strictly conserved in Vav1 and absent from Vav2 in tetrapods. Conversely, the catalytic activity of Vav2 contributes to the suppression of TCR-mediated Ca 2+ entry. By performing an in vivo ‘ GEF trapping’ assay in intact cells, we demonstrate that Cdc42...
Journal Articles
J Cell Sci (2020) 133 (3): jcs237982.
Published: 13 February 2020
...-licence-1-1/ Highlighted Article: The vesicle-tethering and fusion factors Boi1 and Boi2 are shown to initiate the formation of actin filaments by recruiting the Bni1–Bud6 actin nucleation complex to sites of exocytosis. Polar growth Vesicular traffic Actin nucleation Cdc42 Split...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (24): jcs230995.
Published: 13 December 2019
... argue that the asymmetric organelle compass is an indispensable element of the polarity network. Cdc42 Actin Intracellular organization Organelle Polarity Cell polarity is involved in many aspects of cell and developmental biology and is of fundamental importance for processes as...
Journal Articles
J Cell Sci (2019) 132 (23): jcs236018.
Published: 03 December 2019
...Brian S. Hercyk; Julie Rich-Robinson; Ahmad S. Mitoubsi; Marcus A. Harrell; Maitreyi E. Das ABSTRACT Cdc42, a conserved regulator of cell polarity, is activated by two GEFs, Gef1 and Scd1, in fission yeast. Why the cell needs two GEFs is unclear, given that they are partially redundant and activate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs230706.
Published: 31 May 2019
... chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...
Journal Articles
J Cell Sci (2019) 132 (10): jcs217869.
Published: 21 May 2019
...Franck Pichaud; Rhian F. Walther; Francisca Nunes de Almeida ABSTRACT Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (8): jcs223743.
Published: 25 April 2019
... formation. Binding is conferred by a FERM/FA domain–kinase domain interaction and detachment promoted by aPKCι-dependent phosphorylation. FARP2 is shown to promote GTP loading of Cdc42, which is consistent with it being involved in upstream regulation of the polarising PAR6–aPKCι complex. However, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs217554.
Published: 30 January 2019
... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: In this Review, we discuss the trajectory towards, and the use of, minimal in vitro systems of cell polarity. Cdc42 Min proteins Cell polarity Microtubules Minimal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs217091.
Published: 03 August 2018
... formation of MSCRs was also induced by the continuous depolarization of the actin cytoskeleton caused by a treatment with latrunculin-A, an effective inhibitor of actin polymerization. Unlike the formation of conventional septin rings, the formation of MSCRs did not require Cdc42 and its effectors, Gic1...
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (14): jcs216580.
Published: 19 July 2018
...Ye Dee Tay; Marcin Leda; Andrew B. Goryachev; Kenneth E. Sawin ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2017) 130 (18): 2971–2983.
Published: 15 September 2017
... these processes are complex. Here, we modify the activity of the two Rho GTPase family members Rac and Cdc42 by optogenetically recruiting specific guanine nucleotide exchange factor (GEF) DH or PH domains to defined regions of the cell membrane. We find that the localized activation of both GTPases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 380–393.
Published: 15 January 2016
... cancer, was recently reported to localize to cell–cell adhesions and to drive epithelial cell colony escape. Here we report that PAK6 targeting to cell–cell adhesions occurs through its N-terminus, requiring both its Cdc42/Rac interactive binding (CRIB) domain and an adjacent polybasic region for maximal...
Journal Articles
J Cell Sci (2015) 128 (22): 4183–4195.
Published: 15 November 2015
... describe how a direct interaction between the Rho GTPase Cdc42 and the GTPase-activating protein (GAP) GRAF1 (also known as ARHGAP26), facilitates rapid cell surface turnover at the leading edge. Both Cdc42 and GRAF1 were required for fluid-phase uptake and regulated the generation of transient GRAF1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (15): 2866–2880.
Published: 01 August 2015
... well as its downstream effector Cdc42 is upregulated in dendritic cells upon maturation. Although dendritic cell maturation was independent of 5-HT 7 R, receptor stimulation affected dendritic cell morphology through Cdc42-mediated signaling. In addition, basal activity of 5-HT 7 R was required for the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4201–4212.
Published: 01 October 2014
... been well studied. Here, we show that tricellulin (also known as MARVELD2), which is localized at tricellular contacts, regulates F-actin organization through Cdc42. Tricellulin-knockdown epithelial cells exhibit irregular polygonal shapes with curved cell borders and impaired organization of F-actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3331–3346.
Published: 01 August 2014
... oncogenic environment. We first show that CDC42 activation in a single epithelial cell results in its efficient matrix metalloproteinase (MMP)-sensitive extrusion through MEK signalling activation and this is supported by E-cad cleavage. Second, using an engineered cleavable form of E-cad, we demonstrate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2040–2052.
Published: 01 May 2014
... Cdc42 is a key regulator of dynamic actin organization. However, little is known about how Cdc42-dependent actin regulation influences steady-state actin structures in differentiated epithelia. We employed inner ear hair-cell-specific conditional knockout to analyze the role of Cdc42 in hair cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2005–2016.
Published: 01 May 2014
...Kyriakos Kokkoris; Daniela Gallo Castro; Sophie G. Martin ABSTRACT Cell polarization relies on small GTPases, such as Cdc42, which can break symmetry through self-organizing principles, and landmarks that define the axis of polarity. In fission yeast, microtubules deliver the Tea1–Tea4 complex to...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 673–685.
Published: 01 February 2014
... signalling network consisting of Grb2, Nck, WIP and N-WASP. Nck is a potent activator of N-WASP–Arp2/3-dependent actin polymerisation. However, recent observations demonstrate that an interaction between Nck and N-WASP is not required for vaccinia actin tail formation. We found that Cdc42 cooperates with Nck...
Includes: Supplementary data