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Keywords: Cbl
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Journal Articles
J Cell Sci (2017) 130 (19): 3282–3296.
Published: 1 October 2017
... to their unique C-termini. RET51, but not RET9, interacts with, and is ubiquitylated by CBL, which is recruited through interactions with the GRB2 adaptor protein. RET51 internalization was not affected by CBL knockout but was delayed in GRB2-depleted cells. In contrast, RET9 ubiquitylation requires...
Journal Articles
J Cell Sci (2017) 130 (19): 3282–3296.
Published: 1 October 2017
... to their unique C-termini. RET51, but not RET9, interacts with, and is ubiquitylated by CBL, which is recruited through interactions with the GRB2 adaptor protein. RET51 internalization was not affected by CBL knockout but was delayed in GRB2-depleted cells. In contrast, RET9 ubiquitylation requires...
Journal Articles
J Cell Sci (2017) 130 (17): 2808–2820.
Published: 1 September 2017
... conditions, ShcD colocalises with the EGFR and facilitates its phosphorylation, ubiquitylation and accumulation in juxtanuclear vesicles identified as Rab11-positive endocytic recycling compartments. Accordingly, ShcD also functions as a constitutive binding partner for the E3 ubiquitin ligase Cbl. EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2808–2820.
Published: 1 September 2017
... conditions, ShcD colocalises with the EGFR and facilitates its phosphorylation, ubiquitylation and accumulation in juxtanuclear vesicles identified as Rab11-positive endocytic recycling compartments. Accordingly, ShcD also functions as a constitutive binding partner for the E3 ubiquitin ligase Cbl. EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3524–3530.
Published: 1 November 2008
...Judith Langenick; Tsuyoshi Araki; Yoko Yamada; Jeffrey G. Williams Cbl proteins downregulate metazoan signalling pathways by ubiquitylating receptor tyrosine kinases, thereby targeting them for degradation. They contain a phosphotyrosine-binding region, comprising an EF-hand and an SH2 domain...
Journal Articles
J Cell Sci (2005) 118 (17): 3959–3971.
Published: 1 September 2005
...Amy Tsacoumango; Song Jae Kil; Liping Ma; Frank D. Sönnichsen; Cathleen Carlin One of the main goals of this study was to understand the relationship between an epidermal growth factor (EGF) receptor dileucine (LL)-motif (679-LL) required for lysosomal sorting and the protein ubiquitin ligase CBL...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (3): 463–473.
Published: 1 February 2003
...Robin M. Scaife; Sara A. Courtneidge; Wallace Y. Langdon The induction of protein tyrosine kinase signaling pathways is a principal mechanism for promoting cellular activation. Biochemical and genetic analyses have implicated the multi-adaptor proto-oncogene protein Cbl as a key negative regulator...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (17): 3075–3081.
Published: 1 September 2001
... signalling output by providing a different combination of downstream effectors at endocytic compartments compared with the plasma membrane. Rab5, Hrs and Cbl, are three examples of proteins that can influence both tyrosine kinase receptor trafficking and signalling pathways. By operating at this intersection...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (2): 215–226.
Published: 15 January 2000
... of these structures is mediated by signalling through Rho GTPases. Here we identify c-Cbl (a multi-adaptor proto-oncogene product involved in protein tyrosine kinase signalling) as an important regulator of the actin cytoskeleton. By immunofluorescence microscopy we have determined that c-Cbl co-localizes...