... role in stem cell function. However, the mechanisms that modulate the function of ECM regulators in the stem cell niche are understudied. Here, we explored the role of the transcription factor (TF) ETS-1, which is expressed in the cathepsin-positive cell population, in regulating the expression...

.... , Isahara , K. , Ohsawa , Y. , Schulz-Schaeffer , W. , Watanabe , T. , Waguri , S. , Kametaka , S. , et al. ( 2000 ). Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons . J. Neurosci.   20 , 6898 - 6906 . 10.1523/JNEUROSCI.20-18...

... lysosomal exocytosis and apoptosis induction. UVA, but not UVB, induced plasma membrane damage, which was repaired by Ca 2+ -dependent lysosomal exocytosis. The lysosomal exocytosis resulted in extracellular release of cathepsin D and acid sphingomyelinase (aSMase). Two hours after UVA irradiation, we...

... proteins to lysosomes even in the absence of endosomal acidification. * Author for correspondence (e-mail: [email protected] ) 28 9 2006 © The Company of Biologists Limited 2006 2006 Mannose 6-phosphate Lysosome Trafficking Cathepsin Hydrolase Biosynthesis...

...Martin Linke; Volker Herzog; Klaudia Brix Cathepsin B, a lysosomal cysteine proteinase, is involved in limited proteolysis of thyroglobulin with thyroxine liberation at the apical surface of thyroid epithelial cells. To analyze the trafficking of lysosomal enzymes to extracellular locations...

...Carmen Tepel; Dieter Brömme; Volker Herzog; Klaudia Brix ABSTRACT Extracellular proteolysis of thyroglobulin at the apical surface of thyroid epithelial cells results in liberation of thyroxine, and is mediated by lysosomal cysteine proteases such as cathepsins B and L. Here, we report...

.... and Hanada , K. ( 1982 ). L- trans -epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L . Biochem. J . 201 , 189 – 198 . 10.1042/bj2010189 Beertsen , W. , Niehof , A. and Everts , V...

...Bonnie F. Sloane; Kamiar Moin; Mansoureh Sameni; Larry R. Tait; Jurij Rozhin; Grace Ziegler ABSTRACT Alterations in trafficking and increases in expression of the lysosomal proteases cathepsins B, D and L have been observed in transformed cells and malignant tumors, including human breast carcinoma...