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Keywords: Catenin
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Journal Articles
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Mechanobiology
J Cell Sci (2016) 129 (1): 80–94.
Published: 1 January 2016
...Huapeng H. Yu; Michael R. Dohn; Nicholas O. Markham; Robert J. Coffey; Albert B. Reynolds ABSTRACT In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3271–3277.
Published: 1 August 2013
...-nucleotide-exchange factors (GEFs). In this study, we identified a novel Rho-specific GEF called TEM4 (tumor endothelial marker 4) that associates with multiple members of the cadherin–catenin complex and with several cytoskeleton-associated proteins. Depending on confluence, TEM4 localized to either actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 403–413.
Published: 15 January 2013
... events that might occur within a key mechanosensitive system at cell–cell junctions; the cadherin–F-actin interface, at which α-catenin and vinculin form a central module. Mechanotransduction at cell–cell junctions emerges as an important signaling mechanism, and we present examples of its potential...
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (24): 4395–4406.
Published: 15 December 2007
...Yayoi Miyashita; Masayuki Ozawa The E-cadherin-catenin complex regulates Ca 2+ -dependent cell-cell adhesion and is localized to the basolateral membrane of polarized epithelial cells. Uncoupling β-catenin from E-cadherin by deletion or substitution mutations causes accumulation of these proteins...
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (12): 2425–2434.
Published: 15 June 2006
...A. Wodarz; D. B. Stewart; W. J. Nelson; R. Nusse Armadillo, the Drosophila homolog of β-catenin, plays a crucial role in both the Wingless signal transduction pathway and cadherin-mediated cell-cell adhesion, raising the possibility that Wg signaling affects cell adhesion. Here, we use a tissue...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (4): 697–710.
Published: 15 February 2005
... bridging neighboring cells. Immunoelectron microscopic analyses reveal that migfilin is closely associated with β-catenin, but not desmosomes, at cell-cell junctions. Furthermore, we show that the C-terminal LIM domains, but not its N-terminal domain, mediates migfilin localization to cell-cell junctions...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (20): 4201–4212.
Published: 15 October 2003
...Agnes Roczniak-Ferguson; Albert B. Reynolds P120-catenin is the prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins involved in cell-cell adhesion. Interestingly, all members of the p120 subfamily have also been observed in the nucleus, suggesting that they have...
Journal Articles
J Cell Sci (2003) 116 (18): 3687–3700.
Published: 15 September 2003
... of junction formation decreases cell-cell adhesion leading to the loss of contact inhibition, which, in vivo, can lead to unregulated growth and tumorigenesis. E-cadherin Catenin Bcl-2 Junction Cell-cell adhesion Cadherins are calcium-dependent transmembrane glycoproteins that mediate cell-cell...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 155–158.
Published: 1 December 1993
...Barry M. Gumbiner; Pierre D. McCrea SUMMARY The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. α-Catenin is related to vinculin and seems to be required for the interaction of cadherins with the actin cytoskeleton. β...