...Huapeng H. Yu; Michael R. Dohn; Nicholas O. Markham; Robert J. Coffey; Albert B. Reynolds ABSTRACT In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial...

...-nucleotide-exchange factors (GEFs). In this study, we identified a novel Rho-specific GEF called TEM4 (tumor endothelial marker 4) that associates with multiple members of the cadherin–catenin complex and with several cytoskeleton-associated proteins. Depending on confluence, TEM4 localized to either actin...

... events that might occur within a key mechanosensitive system at cell–cell junctions; the cadherin–F-actin interface, at which α-catenin and vinculin form a central module. Mechanotransduction at cell–cell junctions emerges as an important signaling mechanism, and we present examples of its potential...

... of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating β-catenin. For example, in common with β-catenin, exogenous expression of destruction complex components, such as GSK3β and axin, promotes degradation of p120-catenin. Again in parallel with β...

...Yayoi Miyashita; Masayuki Ozawa The E-cadherin-catenin complex regulates Ca 2+ -dependent cell-cell adhesion and is localized to the basolateral membrane of polarized epithelial cells. Uncoupling β-catenin from E-cadherin by deletion or substitution mutations causes accumulation of these proteins...

...Steven Goossens; Barbara Janssens; Stefan Bonné; Riet De Rycke; Filip Braet; Jolanda van Hengel; Frans van Roy Alpha-catenins play key functional roles in cadherin-catenin cell-cell adhesion complexes. We previously reported on αT-catenin, a novel member of the α-catenin protein family. αT-catenin...

...A. Wodarz; D. B. Stewart; W. J. Nelson; R. Nusse Armadillo, the Drosophila homolog of β-catenin, plays a crucial role in both the Wingless signal transduction pathway and cadherin-mediated cell-cell adhesion, raising the possibility that Wg signaling affects cell adhesion. Here, we use a tissue...

... bridging neighboring cells. Immunoelectron microscopic analyses reveal that migfilin is closely associated with β-catenin, but not desmosomes, at cell-cell junctions. Furthermore, we show that the C-terminal LIM domains, but not its N-terminal domain, mediates migfilin localization to cell-cell junctions...

... cells on a highly active N-cadherin homophilic ligand. Cells responded to N-cadherin activation by extending lamellipodium and organizing cadherin-catenin complexes and actin filaments in cadherin adhesions. Lamellipodium protrusion, associated with actin polymerization at the leading edge sustained...

...Agnes Roczniak-Ferguson; Albert B. Reynolds P120-catenin is the prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins involved in cell-cell adhesion. Interestingly, all members of the p120 subfamily have also been observed in the nucleus, suggesting that they have...

... of junction formation decreases cell-cell adhesion leading to the loss of contact inhibition, which, in vivo, can lead to unregulated growth and tumorigenesis. E-cadherin Catenin Bcl-2 Junction Cell-cell adhesion Cadherins are calcium-dependent transmembrane glycoproteins that mediate cell-cell...

...Sirpa Aho; Laura Levänsuo; Outi Montonen; Csaba Kari; Ulrich Rodeck; Jouni Uitto P120 catenin (p120ctn) belongs to the Armadillo family of proteins, which is implicated in cell-cell adhesion and signal transduction. Owing to alternative splicing and multiple translation initiation codons, several...

...Barbara Janssens; Steven Goossens; Katrien Staes; Barbara Gilbert; Jolanda van Hengel; Cecile Colpaert; Erik Bruyneel; Marc Mareel; Frans van Roy Cadherins are major cell-cell adhesion proteins whose cytoplasmic domains bind to catenin proteins. Strong intercellular adhesion depends on linkage...

...Barry M. Gumbiner; Pierre D. McCrea SUMMARY The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. α-Catenin is related to vinculin and seems to be required for the interaction of cadherins with the actin cytoskeleton. β...