... are degraded or recycled. * Author for correspondence ( donaldsonj@helix.nih.gov ) Competing interests The authors declare no competing interests. 19 05 2014 13 08 2014 © 2014. Published by The Company of Biologists Ltd 2014 TRE17 USP6 Ubiquitin Cargo sorting Ubiquitin...

... the mosaic layout of endosomes that underpins cargo sorting. References Allan   V. J. ( 2011 ). Cytoplasmic dynein.   Biochem. Soc. Trans.   39 , 1169 – 1178 . 10.1042/BST0391169 Ally   S. , Larson   A. G. , Barlan   K. , Rice   S. E. , Gelfand   V. I. ( 2009 ). Opposite...

... and clustered cargo molecules into a nascent transport vesicle. Here, AP-2, the heterotetrameric plasma membrane adaptor ( Ohno, 2006 ), executes the pivotal task of connecting the clathrin scaffold to the designated cargo being concentrated within the membrane-bound vesicle. Clathrin Cargo sorting...

... COPII Cargo sorting GTP hydrolysis Transport of proteins from the endoplasmic reticulum (ER) to the Golgi is the first transport step in the secretory pathway ( Barlowe, 2002 ; Klumperman, 2000 ). Data have accumulated into a model in which transport is mediated by the sequential action...