...Denggao Yao; Claire L. Alexander; Jean A. Quinn; Weng-Chyn Chan; Hong Wu; David A. Greenhalgh To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate Pten function ( K14.cre/ Δ 5Pten flx ) in mouse epidermis expressing activated Fos...

... and survival pathways, including PI 3-kinase/AKT, MEK-MAPK, STAT3 and NF-κB, in the transgenic skin in situ. Finally, Inv-Dsg2 transgenic mice developed intraepidermal skin lesions resembling precancerous papillomas and were more susceptible to chemically induced carcinogenesis. In summary, overexpression...

... in the regulation of TNF-α-induced anchorage-independent cell growth, at least partially, by inducing COX-2 expression in Cl41 cells. These findings suggest that NFAT3/cyclooxygenase-2 act as a link between inflammation and carcinogenesis by being involved in the tumor promotion stage. ‡ Author...

... the frequency of papillomas, carcinomas and metastases induced by chemical carcinogenesis, independent of the β4 cytoplasmic domain. Suprabasal α6β4 also perturbed transforming growth factor β (TGFβ) signalling as demonstrated by decreased nuclear Smad2 in transgenic epidermis and tumours. In cultured...

... involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication. Carcinogenesis 22 , 221 -231. de Feijter, A. W., Ray, J. S., Weghorst, C. M., Klaunig, J. E.,Goodman, J. I., Chang, C. C., Ruch, R. J. and Trosko, J. E. ( 1990 ). Infection of rat liver epithelial cells...

... of Medicine, University of California, Davis, Davis, California 95616, USA © 1992 by Company of Biologists 1992 cell growth phorbol esters carcinogenesis mitogenesis The protein kinase C (PKC) family of enzymes has been the subject of a great deal of research in the last few years...