...Cláudia S. F. Queiroga; Raquel M. A. Alves; Sílvia V. Conde; Paula M. Alves; Helena L. A. Vieira ABSTRACT The neuroprotective role of carbon monoxide (CO) has been studied in a cell-autonomous mode. Herein, a new concept is disclosed – CO affects astrocyte–neuron communication in a paracrine manner...

...Hagit B. Suliman; Martha S. Carraway; Lynn G. Tatro; Claude A. Piantadosi To investigate a possible new physiological role of carbon monoxide (CO), an endogenous gas involved in cell signaling and cytotoxicity, we tested the hypothesis that the mitochondrial generation of reactive oxygen species...

.... Exogenous carbon monoxide (CO) is also known to inhibit cytochrome c oxidase in vitro; however, it is not clear whether endogenously produced CO can inhibit cellular respiration and, if so, what the significance of this might be. In this study, we show that exogenous CO inhibits respiration in a moderate...