...Md Hashim Reza; Srijana Dutta; Rohit Goyal; Hiral Shah; Gautam Dey; Kaustuv Sanyal ABSTRACT Candida albicans is the most prevalent fungal pathogen associated with candidemia. Similar to other fungi, the complex life cycle of C. albicans has been challenging to study with high-resolution microscopy...

...Rohan P. Choraghe; Tomasz Kołodziej; Alan Buser; Zenon Rajfur; Aaron K. Neumann; Ana-Maria Lennon-Duménil ABSTRACT Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is an innate immune pattern recognition receptor that recognizes β-glucan on the Candida albicans cell wall...

... with the large C-terminal non-kinase region which, however, is poorly defined. By systematically dissecting and functionally characterizing the non-kinase region of Gin4 in the human fungal pathogen Candida albicans , we report the identification of three new domains with distinct functions: a lipid-binding...

...Chang-Run Li; Jie-Ying Au Yong; Yan-Ming Wang; Yue Wang Cyclin-dependent kinases (CDKs) regulate septin organization in a cell-cycle-dependent manner in yeast. However, the mechanism remains unclear. Here, we show that the Candida albicans CDK Cdc28 phosphorylates the Nim1-related kinase Gin4...

... Candida albicans , chitin synthase 3 (Chs3) synthesises the majority of chitin in the cell wall and is localised at the tips of growing buds and hyphae, and at the septum. An analysis of the C. albicans phospho-proteome revealed that Chs3 can be phosphorylated at Ser139. Mutation of this site showed...

...Kenneth R. Finley; Kelly J. Bouchonville; Aaron Quick; Judith Berman Candida albicans , the most prevalent fungal pathogen of humans, grows with multiple morphologies. The dynamics of nuclear movement are similar in wild-type yeast and pseudohyphae: nuclei divide across the bud neck. By contrast...

...Chang-Run Li; Raymond Teck-Ho Lee; Yan-Ming Wang; Xin-De Zheng; Yue Wang The growing tips of Candida albicans hyphae are sites of polarized exocytosis. Mammalian septins have been implicated in regulating exocytosis and C. albicans septins are known to localize at hyphal tips, although...

...Richard Barton; Keith Gull ABSTRACT Candida albicans is a dimorphic fungus capable of growing as a budding yeast and as a filamentous hypha. We have used the technique of immunofluorescence to study the changes in the microtubule cytoskeleton during the cell cycle in both growth forms...

...Kenji Tanaka; Toshio Kanbe; Tsuneyoshi Kuroiwa ABSTRACT This study was done to correlate mitochondrial behaviour with nuclear behaviour and cell division as well as with the germ tube formation in the dimorphic yeast Candida albicans . Threedimensional reconstruction of electron micrographs...