...Emma Evergren; Ian G. Mills; Grace Kennedy ABSTRACT Membrane trafficking, a fundamental cellular process encompassing the transport of molecules to specific organelles, endocytosis at the plasma membrane and protein secretion, is crucial for cellular homeostasis and signalling. Cancer cells adapt...

... organisms, specific activating signals or downstream responses of atypical MAPK signaling pathways have not yet been identified even though these MAPKs are associated with many eukaryotic processes, including cancer and embryonic development. In this Review, we discuss recent studies that are shedding new...

...Juma Ward; Paul Martin ABSTRACT Previous clinical studies and work in mouse models have indicated that platelets and microclots might enable the recruitment of immune cells to the pre-metastatic cancer niche, leading to efficacious extravasation of cancer cells through the vessel wall. Here, we...

... by oxidative stress. PTEN monoubiquitylation also increases its interaction with nuclear CHIP. PTEN CHIP Monoubiquitylation Nuclear import Tumor suppression Cancer Department of Science and Technology, Ministry of Science and Technology, India DST/NM/NT/2018/105(G) EMR/2017/000992...

... Chromatin 13 , 29 . 10.1186/s13072-020-00352-w Demetriadou , C. , Pavlou , D. , Mpekris , F. , Achilleos , C. , Stylianopoulos , T. , Zaravinos , A. , Papageorgis , P. and Kirmizis , A. ( 2019 ). NAA40 contributes to colorectal cancer growth by controlling...

... overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis. Necroptosis RIPK1 RIPK3 ZBP1 TRIF RHIM Inflammation TNF Necrosis Cancer National Institutes of Health http://dx.doi.org/10.13039/100000002 AI148302...

..., compromising its native tumor suppressive functions. Recently, p53 has been shown to form amyloids, which play a role in conferring cancerous properties to cells, leading to tumorigenesis. However, the exact pathways involved in p53 amyloid-mediated cellular transformations are unknown. Here, using...

..., including lysosome storage diseases, and also cancer, neurodegenerative and cardiovascular diseases (reviewed in Ballabio and Bonifacino, 2020 ). Lysosomes contain a complex enzymatic cocktail that enables the degradation of any biological material. For this reason, permeabilization of the lysosomal...

... on cell proliferation. In contrast, Ki-67 is important for localising nucleolar material to the mitotic chromosome periphery and for structuring perinucleolar heterochromatin, and emerging data indicate that it also has critical roles in cancer development. However, its mechanisms of action have not yet...

... calibration of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048...

... mammary epithelial cells, induction of the UFIT pathway promotes epithelial-to-mesenchymal transition (EMT) and accelerates the endocytosis of several transmembrane receptors, including AXL, in flotillin-positive late endosomes. AXL overexpression, frequently observed in cancer cells, is linked to EMT...

...Wei Xiong Siow; Yaschar Kabiri; Rachel Tang; Yu-Kai Chao; Eva Plesch; Carola Eberhagen; Florian Flenkenthaler; Thomas Fröhlich; Franz Bracher; Christian Grimm; Martin Biel; Hans Zischka; Angelika M. Vollmar; Karin Bartel ABSTRACT Liver cancers, including hepatocellular carcinoma (HCC...

... of this magnitude die. However, some CTCs develop resistance to this FSS, allowing them to colonize distant organs. We explored how prostate CTCs can resist cell death in response to forces of this magnitude. The DU145, PC3 and LNCaP human prostate cancer cell lines were used to represent cells of different...

... leads to nephrotic syndrome ( Lee et al., 2017 ). These mouse studies indicate that both overexpression and lack of TNS2 results in nephrotic syndrome. The results from the two GWAS suggest that TNS3 is associated with pancreatic cancer ( Klein et al., 2018 ). However, we did not observe...

...Timothy Marsh; Bhairavi Tolani; Jayanta Debnath ABSTRACT Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to metastatic progression, the principle cause of cancer-related mortality, is only now...

... is controlled by programmed cell death 4 (PDCD4), which sequesters free eIF4A (see poster). PDCD4 is inhibited downstream of mTORC1, allowing increased eIF4A c formation. Mammals express two eIF4A paralogues, eIF4A1, which has been most studied in cancer, and eIF4A2. Both paralogues are structurally similar...

... transcriptionally represses integrins via a SHC–MEK signaling axis, and communicates with neighboring cells through TNFα to promote cooperative invasion. Cancer Extracellular matrix Adhesion Invasion National Institutes of Health 10.13039/100000002 R01CA206880 R21CA217735 R01NS080939...

... and a key vulnerability for tumours. Finally, we review how new insights into tumour–microenvironment interactions has led to the current consensus on how these processes may be targeted as novel anti-cancer therapies. * These authors contributed equally to this work ‡ Author for correspondence...

... example. We discuss how the use of rigid tissue culture plastic for cancer drug screening may select agents that lack efficacy in the soft in vivo tissue environment. Tuning of integrin signaling via external mechanical forces in vivo and subsequent effects on growth factor signaling thus has implications...

...Amelia R. Townley; Sally P. Wheatley ABSTRACT Survivin (also known as BIRC5) is a cancer-associated protein that is pivotal for cellular life and death – it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria...