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Keywords: Cancer
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Journal Articles
J Cell Sci (2022) 135 (17): jcs260091.
Published: 13 September 2022
... overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis. Necroptosis RIPK1 RIPK3 ZBP1 TRIF RHIM Inflammation TNF Necrosis Cancer National Institutes of Health http://dx.doi.org/10.13039/100000002 AI148302...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (15): jcs259500.
Published: 1 August 2022
..., compromising its native tumor suppressive functions. Recently, p53 has been shown to form amyloids, which play a role in conferring cancerous properties to cells, leading to tumorigenesis. However, the exact pathways involved in p53 amyloid-mediated cellular transformations are unknown. Here, using...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs255802.
Published: 10 June 2022
..., factors controlling genomic stability. In this Review, we discuss the latest advances in this area and highlight the therapeutic potential of targeting autophagy for drug development. Mitotic poisons are widely used in the clinic to treat cancer, but unfortunately, they also cause highly detrimental...
Journal Articles
J Cell Sci (2022) 135 (11): jcs258932.
Published: 8 June 2022
... on cell proliferation. In contrast, Ki-67 is important for localising nucleolar material to the mitotic chromosome periphery and for structuring perinucleolar heterochromatin, and emerging data indicate that it also has critical roles in cancer development. However, its mechanisms of action have not yet...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... ≤0.05, ** P ≤0.01, *** P ≤0.001 and **** P ≤0.0001. All box plots were plotted using the Tukey method. We thank members of the Logue Lab for insightful discussions. We also thank the administrative staff within the Department of Regenerative and Cancer Cell Biology at the Albany Medical College...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (7): jcs259178.
Published: 8 April 2022
... mammary epithelial cells, induction of the UFIT pathway promotes epithelial-to-mesenchymal transition (EMT) and accelerates the endocytosis of several transmembrane receptors, including AXL, in flotillin-positive late endosomes. AXL overexpression, frequently observed in cancer cells, is linked to EMT...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2022) 135 (6): jcs259455.
Published: 21 March 2022
...Wei Xiong Siow; Yaschar Kabiri; Rachel Tang; Yu-Kai Chao; Eva Plesch; Carola Eberhagen; Florian Flenkenthaler; Thomas Fröhlich; Franz Bracher; Christian Grimm; Martin Biel; Hans Zischka; Angelika M. Vollmar; Karin Bartel ABSTRACT Liver cancers, including hepatocellular carcinoma (HCC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs251470.
Published: 22 February 2021
... of this magnitude die. However, some CTCs develop resistance to this FSS, allowing them to colonize distant organs. We explored how prostate CTCs can resist cell death in response to forces of this magnitude. The DU145, PC3 and LNCaP human prostate cancer cell lines were used to represent cells of different...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs254029.
Published: 17 February 2021
.... Tensin CTEN SH2 PTB Focal adhesion Mitral valve prolapse Cystic kidney Nephrotic syndrome Cancer Tensin was first reported in 1991 as an actin-binding focal-adhesion protein containing a Src homology 2 (SH2) domain, a newly identified binding motif specific for phosphotyrosine (pTyr...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247056.
Published: 22 January 2021
...Timothy Marsh; Bhairavi Tolani; Jayanta Debnath ABSTRACT Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to metastatic progression, the principle cause of cancer-related mortality, is only now...
Journal Articles
J Cell Sci (2021) 134 (1): jcs248476.
Published: 13 January 2021
... controversial ( Westman et al., 2005 ; Yan et al., 2005 ; Kentsis et al., 2005 ). This compound has been used in over 10 cancer trials, displaying few side-effects and high efficacy (reviewed by Casaos et al., 2019 ). Two classes of mRNAs are particularly sensitive to eIF4E expression. mRNAs with long 5...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247189.
Published: 24 December 2020
...., A.J.E., F.F.; Writing - review & editing: A.B., A.J.E., F.F.; Supervision: A.J.E., F.F.; Project administration: A.J.E., F.F.; Funding acquisition: A.J.E., F.F. Funding Funding was provided by direct support from the Ludwig Institute for Cancer Research, National Institutes of Health (grant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247783.
Published: 22 December 2020
... and a key vulnerability for tumours. Finally, we review how new insights into tumour–microenvironment interactions has led to the current consensus on how these processes may be targeted as novel anti-cancer therapies. © 2020. Published by The Company of Biologists Ltd 2020 Summary: An outline...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs242461.
Published: 11 December 2020
... example. We discuss how the use of rigid tissue culture plastic for cancer drug screening may select agents that lack efficacy in the soft in vivo tissue environment. Tuning of integrin signaling via external mechanical forces in vivo and subsequent effects on growth factor signaling thus has implications...
Journal Articles
J Cell Sci (2020) 133 (21): jcs247379.
Published: 12 November 2020
...Amelia R. Townley; Sally P. Wheatley ABSTRACT Survivin (also known as BIRC5) is a cancer-associated protein that is pivotal for cellular life and death – it is an essential mitotic protein and an inhibitor of apoptosis. In cancer cells, a small pool of survivin localises to the mitochondria...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs238931.
Published: 1 September 2020
...Yuki Yoshino; Akihiro Kobayashi; Huicheng Qi; Shino Endo; Zhenzhou Fang; Kazuha Shindo; Ryo Kanazawa; Natsuko Chiba ABSTRACT Breast cancer gene 1 (BRCA1) contributes to the regulation of centrosome number. We previously identified receptor for activated C kinase 1 (RACK1) as a BRCA1-interacting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs239434.
Published: 15 June 2020
... complex multicellular structures. Perturbing components of this axis results in aberrant cell–cell adhesion and signaling leading to the initiation of various pathologies, including neurodegeneration, fibrosis and cancer. As discussed in this Review, understanding the functions for αvβ8 integrin, its ECM...
Journal Articles
J Cell Sci (2020) 133 (8): jcs236778.
Published: 28 April 2020
...Asja Guzman; Rachel C. Avard; Alexander J. Devanny; Oh Sang Kweon; Laura J. Kaufman ABSTRACT The study of cancer cell invasion in 3D environments in vitro has revealed a variety of invasive modes, including amoeboid migration, characterized by primarily round cells that invade in a protease...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs228072.
Published: 7 April 2020
... increased cell proliferation, while downregulated NEDD4 in prostate carcinoma cells inhibited colony formation and induced apoptosis ( Li et al., 2015 ). SMURF1, another NEDD4 family member, also regulates cancer cell proliferation by modulating the ubiquitylation and stability of estrogen receptor alpha...
Includes: Supplementary data