...David B. Williams Calnexin and calreticulin are related proteins that comprise an ER chaperone system that ensures the proper folding and quality control of newly synthesized glycoproteins. The specificity for glycoproteins is conferred by a lectin site that recognizes an early oligosaccharide...

... a receptor co-complex involving calreticulin and low-density lipoprotein (LDL)receptor-related protein (LRP). We postulate that this transition to an intermediate adhesive state enhances cellular responses to dynamic environmental conditions. Since cell adhesion dynamics affect cell motility,we asked whether...

... approach. Processing of carboxy-terminal fibrillin-1 was strongly influenced by N-glycosylation at the site immediately downstream of the furin site, and by association with calreticulin. The carboxy terminus of fibrillin-2 underwent less efficient processing than carboxy-terminal fibrillin-1 under...

... of calreticulin, a soluble 60 kDa KDEL-protein of the ER. Immunogold labelling established the ER localization of calreticulin in transfected and nontransfected COS cells. Although the ER cisternae in transfected cells were enormously dilated and heavily labelled by gold particles we found no significant label...

...Chung Yee Leung-Hagesteijn; Kosta Milankov; Marek Michalak; John Wilkins; Shoukat Dedhar ABSTRACT We have demonstrated recently that calreticulin, an intra-cellular calcium-binding protein, can interact with the α-subunits of integrin receptors via the highly conserved KXGFFKR amino acid sequence...