...Tim Pieters; Frans van Roy ABSTRACT Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and catenins – their cytoplasmic scaffold proteins – in the fate, maintenance and differentiation of mammalian...

...Emilie Guillaume; Franck Comunale; Nam Do Khoa; Damien Planchon; Stéphane Bodin; Cécile Gauthier-Rouvière Summary Cadherins are essential in many fundamental processes and assemble at regions of cell–cell contact in large macromolecular complexes named adherens junctions. We have identified...

...Matthew D. Langer; Huabei Guo; Nitesh Shashikanth; J. Michael Pierce; Deborah E. Leckband We present direct evidence that the N-glycosylation state of neural cadherin impacts the intrinsic kinetics of cadherin-mediated intercellular binding. Micropipette manipulation measurements quantified...

...Peter J. B. Sabatini; Ming Zhang; Rosalind V. Silverman-Gavrila; Michelle P. Bendeck Cadherins aggregate and stabilize cell–cell junctions through interactions with adjacent cells. In addition, N-cadherin and E-cadherin concentrate at free edges or at the lamellipodia of migrating cells...

...Samantha J. Stehbens; Andrew D. Paterson; Matthew S. Crampton; Annette M. Shewan; Charles Ferguson; Anna Akhmanova; Robert G. Parton; Alpha S. Yap In contrast to the well-established relationship between cadherins and the actin cytoskeleton, the potential link between cadherins and microtubules...

...Porntula Panorchan; Melissa S. Thompson; Kelly J. Davis; Yiider Tseng; Konstantinos Konstantopoulos; Denis Wirtz Cadherins are ubiquitous cell surface molecules that are expressed in virtually all solid tissues and localize at sites of cell-cell contact. Cadherins form a large and diverse family...

...Juankun Zhang; Martha Betson; Jennifer Erasmus; Kostas Zeikos; Maryse Bailly; Louise P. Cramer; Vania M. M. Braga The ability of epithelial cells to polarize requires cell-cell adhesion mediated by cadherin receptors. During cell-cell contact, the mechanism via which a flat, spread cell shape...

...Fiorella Balzac; Maria Avolio; Simona Degani; Irina Kaverina; Mauro Torti; Lorenzo Silengo; J. Victor Small; Saverio Francesco Retta The coordinate modulation of cadherin and integrin functions plays an essential role in fundamental physiological and pathological processes, including morphogenesis...

... and by expressing E-cadherin mutants unable to bind p120. This resulted in defective eye formation and provoked malformations in the craniofacial cartilage structures, derivatives of the cranial neural crest cells. Closer inspection showed that p120 depletion impaired evagination of the optic vesicles and migration...

...Charlles H. M. Castro; Chan Soo Shin; Joseph P. Stains; Su-Li Cheng; Sharmin Sheikh; Gabriel Mbalaviele; Vera Lucia Szejnfeld; Roberto Civitelli We studied the function of osteoblast cadherins in vivo by transgenic expression of a truncated N-cadherin with dominant-negative action, driven...

... glycoproteins N-cadherin and cadherin-11 [which also occur in heterotypic (`mixed') complexes] are associated with α- and β-catenin, plakoglobin (proportions variable among species), p120 ctn and vinculin. The other complex contains ezrin, periplakin, periaxin and desmoyokin (and so is called the EPPD complex...

...Elizabeth E. Robinson; Kathleen M. Zazzali; Siobhan A. Corbett; Ramsey A. Foty Integrins and cadherins are considered to have distinct and opposing functions. Integrins are traditionally cited for their role in cell-substratum interactions, whereas cadherins are thought to mediate strong...

...Snježana Kutleša; Johannes T. Wessels; Angelika Speiser; Inge Steiert; Claudia A. Müller; Gerd Klein Cadherins are a family of cell adhesion molecules that mainly mediate homotypic homophilic interactions, but for E-cadherin, heterophilic interactions with the integrin α E (CD103)β 7 have also...

... culture medium) for 3 days. Paraformaldehyde-fixed monolayers were permeabilized with Triton R X-100 prior to the detection of filamentous actin, using phalloidin-FITC. Vimentin filaments, cytokeratin filaments, microtubules, E- and N-cadherins as molecules of cell adhesion plaques, and fibronectin...

...Hiroaki Matsunami; Seiji Miyatani; Takayoshi Inoue; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Masatoshi Takeichi ABSTRACT R-cadherin was originally identified as a chicken cad- herin expressed by the retina. Here, we describe the identification of a mouse homologue of R-cadherin. We...

...Pilar Navarro; Encarnación Lozano; Amparo Cano ABSTRACT Transfection of E- and P-cadherin cDNA has been carried out in murine spindle carcinoma cells previously shown to be deficient in both cadherins (Navarro et al., J. Cell Biol . 115, 517-533, 1991). High levels of expression of E- or P-cadherin...

.... To substantiate the sequence similarity, properties of Armadillo were evaluated for consistency with a junctional role. Armadillo is part of a membrane-associated complex. This complex includes Armadillo, a glycoprotein similar in size to vertebrate cadherins, and the Drosophila homolog of α-catenin. Armadillo co...

.... The transmembrane adhesion molecules present in these sites are members of the cadherin family, which are recognized by a pan-cadherin serum, directed against the conserved C terminus of these molecules. Immunoblotting analysis of cultured human endothelial cells using these antibodies revealed three immunoreactive...